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- W174674003 abstract "Present address: 1,2,4, Scientist, Animal Biotechnology Section (bjyotsana@gmail.com), 3Scientist, Division of Livestock and Fishery Management, ICAR Regional Complex for Eastern Region, Patna, Bihar. 7Senior Scientist, Animal Biotechnology Section, 6Scientist, 5Senior Scientist, Animal Genetic and Breeding Division. β-lactoglobulin (β-LG) protein coded by (β-LG) gene is one of the major whey protein present in ruminants milk representing about 50% of the total protein. β-LG gene is located on chromosome 3 with 4.9 Kb long transcription units comprising 7 exons and 6 introns. As β-LG is able to bind a variety of hydrophobic molecules including retinol and small fatty acids, its role in transport of vitamin A was also proposed. Milk protein polymorphism can serve as a marker and have been considered as a potential tool for selection of dairy ruminants. It is one of the several positional candidate genes which may affect milk production traits in sheep. The polymorphism is due to single nucleotide substitution in exonII (T–C), expressed as a change of the 20th amino acid (Tyr to His). This substitution disrupts RsaI site which can be detected by PCR-RFLP. Allelic variants A and B differ by a Tyr/His substitution, where β-LG A has Tyr and β-LG B has His (Kolde and Braunitzer 1983). The rare variant β-LG C is a subtype of ovine β-LG A with a single exchange of ArgGlu (Erhardt 1989). Several studies has been carried out to study polymorphism in ovine β-Lactoglobulin gene (Cubric-Curik et al. 2002), Barillet et al. (2005), Kucinskiene et al. (2005), Cengiz et al. (2006), Dario et al. (2005), Dario et al. (2008), Baranyi et al. (1993), Arora et al. (2010). Ovine milk has a unique whey protein composition as compared to that of bovine whey and it is especially rich in proteins (Moatsou et al. 2005). The uniqueness of sheep milk and its cheese production characteristics, has spurred considerable research into genetic structure of milk related genes in sheep populations. Milk production of an ewe has an important effect on the pre-weaning growth and survival of lambs especially in case of twins and triplets. Improvement in milk producing ability of ewes and lamb Indian Journal of Animal Sciences 84 (10): 1133–1136, October 2014/Short Communication" @default.
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- W174674003 date "2014-01-01" @default.
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- W174674003 title "β-Lactoglobulin gene polymorphism in Indian sheep breeds of different agro-climatic regions" @default.
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