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- W174719150 abstract "Spectral optical coherence microscopy (SOCM) [1] combines the advantages of spectral OCT such as imaging speed, detection sensitivity and the availability of signal phase with the high lateral resolution of microscopy. The depth resolution is given by the coherence length of the employed light source which in turn is proportional to the spectral width. The transverse resolution is determined by the numeric aperture of the objective. The parallel detection in depth however has the drawback of losing transverse resolution along the optical axis especially if high numeric aperture objectives are used. We present a method where the sample is illuminated by a concentric interference pattern obtained via an axicon lens. With a broadband spatially coherent light source the side lobes largely cancel out so that mainly the central interference lobe remains like a transversally highly confined needle along the full intersection volume. Nearly constant transverse resolution of ~1.5µm along a focal range of 200µm with a maximum sensitivity of 105dB was obtained. A broad bandwidth Ti:Sapphire laser allowed for an axial resolution of 3µm in air, providing the nearly isotropic resolution necessary to access the microstructure of biological tissues. Together with the speedand sensitivity-advantage of SOCT, this system can perform in vivo measurements in a minimally invasive way. Tomograms of the mouse mammary gland recorded in vitro, revealed biologically relevant structural details (Fig. 1). The acquired tomograms demonstrate a high image contrast comparable to that of stained samples or fluorescence microscopy and validate the performance of the described setup. Comparing the tomograms with other imaging methodologies allows qualitative validation of the measured structures and to get a better OCT image interpretation. In addition it demonstrates the high potential of FDOCM for minimally-invasive small animal imaging since neither contrast agents, nor labeling, nor slicing of the sample are needed. This research was funded y the Swiss National Fonds (SNF grant Nr. 205321-10974)." @default.
- W174719150 created "2016-06-24" @default.
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- W174719150 date "2006-01-01" @default.
- W174719150 modified "2023-10-02" @default.
- W174719150 title "HIGH CONTRAST 3D IMAGING USING HIGH SPEED EXTENDED-FOCUS OPTICAL COHERENCE MICROSCOPY" @default.
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