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- W1747377309 abstract "The aim of this study was to evaluate the effects of propofol on cortical electroencephalogram (EEG) in seven dogs. Propofol infusion was accomplished from low concentration to high concentration in series, and each concentration was infused for 20 minutes(M0 : 0, M0.5 : 0.5, M1.0 : 1.0, and M1.5 : 1.5 mg/kg/min of infusion rate). EEG was recorded via needle electrode placed at Cz, which was applied to International 10-20 system. Arterial blood pressure, blood gas analysis and ECG were also measured. Hemodynamics, PaCO2, PaO2, heart rate and respiratory rate were variable, but were not significant(p>0.05). The power spectra of EEG in every concentration was compared with those of control (M0). The powers at all frequencies at M1.0 and M1.5 were decreased. Especially, the powers of the frequencies over 20 Hz were significantly decreased(p<0.05). Powers at frequencies between 8 and 15 Hz at M0.5 were significantly increased(p<0.05) in response to the painful stimuli. It was inferred that they may reflect activity of the brain which is consciously processing the external stimuli. Like the power spectra, all the band powers of the EEG (δ 1-4, θ 4-8, α 8-13, βL 13-21, βH 21-30, γ 30-50, and total 1-50 Hz) were decreased in proportion to the increase of infusion rate at M1.0 and M1.5. Especially, decreases of βH and γ were significant(p<0.01). At M0.5, α band was significantly increased(p<0.05) among all the bands. Seizure activities which were concide with occurrence of spike wave were shown in all dogs at M1.0 and M1.5." @default.
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- W1747377309 date "2000-01-01" @default.
- W1747377309 modified "2023-09-26" @default.
- W1747377309 title "Effects of propofol on electroencephalogram in dogs." @default.
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