Matches in SemOpenAlex for { <https://semopenalex.org/work/W174774135> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W174774135 abstract "With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. After receptor activation through ligand binding, Smads mediate the signal from the receptor complex to the nucleus, where they orchestrate transcription. Depending on the context of activation, TGF-β can mediate a plethora of cellular responses, including proliferation, growth arrest, apoptosis and differentiation. In cancer, TGF-β can act as both as a tumor suppressor and promoter. During early stages of tumorigenesis, TGF-β prevents proliferation. However, TGF-β is also known to promote tumor progression during later stages of the disease, where it can induce differentiation of cancer cells towards a migratory phenotype. The aim of this thesis was to investigate how cells can differentiate their response upon TGF-β pathway activation. The first paper describes the role of Notch signaling in TGF-β induced growth arrest, demonstrating that TGF-β promotes Notch activity and that Notch signaling is required for prolonged TGF-β induced cell cycle arrest. In the second and third paper, we investigate the role of SIK, a member of the AMPK family of kinases, mediating signaling strength of TGF-β through degradation of the TGF-β type I receptor ALK5. While the second paper focuses on the effect of SIK on ALK5 stability and subsequent alterations in TGF-β signaling, the third paper emphasizes cooperation between SIK, Smad7 and the E3 ligase Smurf in degradation of ALK5. Finally, the fourth paper explores a novel role of SIK during TGF-β induced epithelial to mesenchymal transition (EMT). SIK binds to and degrades the polarity protein Par3, leading to enhanced EMT." @default.
- W174774135 created "2016-06-24" @default.
- W174774135 creator A5001204975 @default.
- W174774135 creator A5004839255 @default.
- W174774135 creator A5009911170 @default.
- W174774135 creator A5050007881 @default.
- W174774135 creator A5072088923 @default.
- W174774135 creator A5084535456 @default.
- W174774135 date "2010-01-01" @default.
- W174774135 modified "2023-10-17" @default.
- W174774135 title "SIK and Smurf2 cooperate to downregulate the TGF-β type I receptor" @default.
- W174774135 hasPublicationYear "2010" @default.
- W174774135 type Work @default.
- W174774135 sameAs 174774135 @default.
- W174774135 citedByCount "0" @default.
- W174774135 crossrefType "journal-article" @default.
- W174774135 hasAuthorship W174774135A5001204975 @default.
- W174774135 hasAuthorship W174774135A5004839255 @default.
- W174774135 hasAuthorship W174774135A5009911170 @default.
- W174774135 hasAuthorship W174774135A5050007881 @default.
- W174774135 hasAuthorship W174774135A5072088923 @default.
- W174774135 hasAuthorship W174774135A5084535456 @default.
- W174774135 hasConcept C104317684 @default.
- W174774135 hasConcept C118131993 @default.
- W174774135 hasConcept C121608353 @default.
- W174774135 hasConcept C125555471 @default.
- W174774135 hasConcept C161879069 @default.
- W174774135 hasConcept C170493617 @default.
- W174774135 hasConcept C2775960820 @default.
- W174774135 hasConcept C2781080636 @default.
- W174774135 hasConcept C502942594 @default.
- W174774135 hasConcept C54355233 @default.
- W174774135 hasConcept C555283112 @default.
- W174774135 hasConcept C62478195 @default.
- W174774135 hasConcept C73568257 @default.
- W174774135 hasConcept C86339819 @default.
- W174774135 hasConcept C86803240 @default.
- W174774135 hasConcept C95444343 @default.
- W174774135 hasConceptScore W174774135C104317684 @default.
- W174774135 hasConceptScore W174774135C118131993 @default.
- W174774135 hasConceptScore W174774135C121608353 @default.
- W174774135 hasConceptScore W174774135C125555471 @default.
- W174774135 hasConceptScore W174774135C161879069 @default.
- W174774135 hasConceptScore W174774135C170493617 @default.
- W174774135 hasConceptScore W174774135C2775960820 @default.
- W174774135 hasConceptScore W174774135C2781080636 @default.
- W174774135 hasConceptScore W174774135C502942594 @default.
- W174774135 hasConceptScore W174774135C54355233 @default.
- W174774135 hasConceptScore W174774135C555283112 @default.
- W174774135 hasConceptScore W174774135C62478195 @default.
- W174774135 hasConceptScore W174774135C73568257 @default.
- W174774135 hasConceptScore W174774135C86339819 @default.
- W174774135 hasConceptScore W174774135C86803240 @default.
- W174774135 hasConceptScore W174774135C95444343 @default.
- W174774135 hasLocation W1747741351 @default.
- W174774135 hasOpenAccess W174774135 @default.
- W174774135 hasPrimaryLocation W1747741351 @default.
- W174774135 hasRelatedWork W127503595 @default.
- W174774135 hasRelatedWork W1564757063 @default.
- W174774135 hasRelatedWork W1966317942 @default.
- W174774135 hasRelatedWork W2000399084 @default.
- W174774135 hasRelatedWork W2006708901 @default.
- W174774135 hasRelatedWork W2022966687 @default.
- W174774135 hasRelatedWork W2039022971 @default.
- W174774135 hasRelatedWork W2055654067 @default.
- W174774135 hasRelatedWork W206794561 @default.
- W174774135 hasRelatedWork W2148317441 @default.
- W174774135 hasRelatedWork W2151916930 @default.
- W174774135 hasRelatedWork W2326415871 @default.
- W174774135 hasRelatedWork W2334026053 @default.
- W174774135 hasRelatedWork W2594009997 @default.
- W174774135 hasRelatedWork W2740258560 @default.
- W174774135 hasRelatedWork W3000949338 @default.
- W174774135 hasRelatedWork W3088723516 @default.
- W174774135 hasRelatedWork W3208628584 @default.
- W174774135 hasRelatedWork W35931135 @default.
- W174774135 hasRelatedWork W46644376 @default.
- W174774135 isParatext "false" @default.
- W174774135 isRetracted "false" @default.
- W174774135 magId "174774135" @default.
- W174774135 workType "article" @default.