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• W1748113823 abstract "Introduction Lung cancer remains the leading cause of cancer-related mortality worldwide. Over the past decade, the development of molecularly targeted therapies coupled with the emergence of immunotherapy has reshaped our approach to the treatment of advanced non-small cell lung cancer (NSCLC). In addition, novel insights into the critical role of angiogenesis in NSCLC development and progression have led to the development of multiple antiangiogenic strategies. These include agents targeting the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) pathway, a key mediator of both normal and pathologic angiogenesis implicated in tumor survival, migration, and mobilization.2-6 This review focuses on the recent developments of antiangiogenic therapies in NSCLC, which fall broadly into 2 categories: neutralizing monoclonal antibodies (mAbs) and small-molecule tyrosine kinase inhibitors (TKIs)." @default.
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• W1748113823 date "2015-10-05" @default.
• W1748113823 modified "2023-09-24" @default.
• W1748113823 title "Antiangiogenic Agents in Lung Cancer: Lost Cause or Flicker of Hope?" @default.
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