Matches in SemOpenAlex for { <https://semopenalex.org/work/W1748259713> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1748259713 abstract "The aim of our study was to search for new, readily available and statistically reliable cytological markers for differentiating benign and malignant follicular thyroid neoplasms pre-operatively.Cohesiveness of tumour cells in cytology slides from a series of 58 follicular tumours diagnosed between 1998 and 2004 inclusive was studied, including 48 follicular adenomas, and eight minimally invasive and two widely invasive follicular carcinomas. Photomicrographs of the cytology slides were taken and the digital images were analysed using computer image analysis software. We evaluated the relative proportions of cells arranged in groups of various sizes. The cohesiveness of the cells in cytological smears was then correlated with the immunohistochemical expression of E-cadherin in corresponding histological slides.Cases from 15 men (26%) and 43 women (74%) with a mean age of 50 years (range, 19-79) were analysed. In follicular adenomas and carcinomas, respectively, isolated cells were seen in 16.8% and 24.7% (P = 0.028), groups of two to five cells in 9.7% and 11.5% (P = 0.145) and groups of more than five cells in 73.5% and 63.8% (P = 0.041). The mean cell count in groups with more than five cells was 46.5 and 27.0 in adenomas and carcinomas, respectively (P < 0.001). Cell cohesiveness, either as percentage of cells in groups of more than five (R(2) = 0.026) or as mean cell count per group of more than five (R(2) = 0.005), was not found to be dependent on the expression of E-cadherin. Using a threshold of 13% isolated tumour cells in cytological smears, follicular adenomas and carcinomas could be distinguished with 90% sensitivity and 41% specificity.Although we demonstrated a statistically significant difference in cell cohesion between follicular adenomas and carcinomas, these could not be distinguished in the clinical setting by evaluation of the percentage of isolated cells in cytological smears because the specificity was too low. The absence of correlation of cellular cohesiveness with E-cadherin expression indicates that other factors are probably responsible for the loss of cohesiveness observed in follicular thyroid malignancy." @default.
- W1748259713 created "2016-06-24" @default.
- W1748259713 creator A5016128041 @default.
- W1748259713 creator A5020726734 @default.
- W1748259713 creator A5023424528 @default.
- W1748259713 creator A5034935594 @default.
- W1748259713 creator A5083472229 @default.
- W1748259713 date "2010-12-28" @default.
- W1748259713 modified "2023-09-25" @default.
- W1748259713 title "Cellular cohesiveness in benign and malignant thyroid follicular tumours varies significantly, but the difference is not useful in diagnosis of individual cases" @default.
- W1748259713 cites W1978050355 @default.
- W1748259713 cites W2005958049 @default.
- W1748259713 cites W2020314607 @default.
- W1748259713 cites W2021767367 @default.
- W1748259713 cites W2032536950 @default.
- W1748259713 cites W2033857103 @default.
- W1748259713 cites W2035141892 @default.
- W1748259713 cites W2035919693 @default.
- W1748259713 cites W2045096224 @default.
- W1748259713 cites W2045294798 @default.
- W1748259713 cites W2045334503 @default.
- W1748259713 cites W2072513651 @default.
- W1748259713 cites W2080820996 @default.
- W1748259713 cites W2086442172 @default.
- W1748259713 cites W2108894834 @default.
- W1748259713 cites W2160376723 @default.
- W1748259713 cites W2166190401 @default.
- W1748259713 cites W2168402896 @default.
- W1748259713 cites W2169588225 @default.
- W1748259713 cites W4231113296 @default.
- W1748259713 cites W71429437 @default.
- W1748259713 doi "https://doi.org/10.1111/j.1365-2303.2010.00834.x" @default.
- W1748259713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21198996" @default.
- W1748259713 hasPublicationYear "2010" @default.
- W1748259713 type Work @default.
- W1748259713 sameAs 1748259713 @default.
- W1748259713 citedByCount "1" @default.
- W1748259713 countsByYear W17482597132016 @default.
- W1748259713 crossrefType "journal-article" @default.
- W1748259713 hasAuthorship W1748259713A5016128041 @default.
- W1748259713 hasAuthorship W1748259713A5020726734 @default.
- W1748259713 hasAuthorship W1748259713A5023424528 @default.
- W1748259713 hasAuthorship W1748259713A5034935594 @default.
- W1748259713 hasAuthorship W1748259713A5083472229 @default.
- W1748259713 hasConcept C126322002 @default.
- W1748259713 hasConcept C142724271 @default.
- W1748259713 hasConcept C187785154 @default.
- W1748259713 hasConcept C18823058 @default.
- W1748259713 hasConcept C204232928 @default.
- W1748259713 hasConcept C2777428134 @default.
- W1748259713 hasConcept C2778057883 @default.
- W1748259713 hasConcept C3018023364 @default.
- W1748259713 hasConcept C3019992690 @default.
- W1748259713 hasConcept C526584372 @default.
- W1748259713 hasConcept C71924100 @default.
- W1748259713 hasConceptScore W1748259713C126322002 @default.
- W1748259713 hasConceptScore W1748259713C142724271 @default.
- W1748259713 hasConceptScore W1748259713C187785154 @default.
- W1748259713 hasConceptScore W1748259713C18823058 @default.
- W1748259713 hasConceptScore W1748259713C204232928 @default.
- W1748259713 hasConceptScore W1748259713C2777428134 @default.
- W1748259713 hasConceptScore W1748259713C2778057883 @default.
- W1748259713 hasConceptScore W1748259713C3018023364 @default.
- W1748259713 hasConceptScore W1748259713C3019992690 @default.
- W1748259713 hasConceptScore W1748259713C526584372 @default.
- W1748259713 hasConceptScore W1748259713C71924100 @default.
- W1748259713 hasLocation W17482597131 @default.
- W1748259713 hasLocation W17482597132 @default.
- W1748259713 hasOpenAccess W1748259713 @default.
- W1748259713 hasPrimaryLocation W17482597131 @default.
- W1748259713 hasRelatedWork W1513727202 @default.
- W1748259713 hasRelatedWork W1967246217 @default.
- W1748259713 hasRelatedWork W1970431144 @default.
- W1748259713 hasRelatedWork W1971763736 @default.
- W1748259713 hasRelatedWork W2011291115 @default.
- W1748259713 hasRelatedWork W2019443178 @default.
- W1748259713 hasRelatedWork W2075083612 @default.
- W1748259713 hasRelatedWork W2082902019 @default.
- W1748259713 hasRelatedWork W2119411052 @default.
- W1748259713 hasRelatedWork W2141379734 @default.
- W1748259713 hasRelatedWork W2317723781 @default.
- W1748259713 hasRelatedWork W2323566994 @default.
- W1748259713 hasRelatedWork W2397263507 @default.
- W1748259713 hasRelatedWork W2399563178 @default.
- W1748259713 hasRelatedWork W2410228011 @default.
- W1748259713 hasRelatedWork W2412429705 @default.
- W1748259713 hasRelatedWork W2413454573 @default.
- W1748259713 hasRelatedWork W2423979024 @default.
- W1748259713 hasRelatedWork W2741748052 @default.
- W1748259713 hasRelatedWork W3207174667 @default.
- W1748259713 isParatext "false" @default.
- W1748259713 isRetracted "false" @default.
- W1748259713 magId "1748259713" @default.
- W1748259713 workType "article" @default.