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- W1748436622 abstract "Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ (IFN-γ) immunity underlie mycobacterial disease. We report the discovery of bi-allelic RORC loss-of-function mutations in seven individuals from three kindreds of different ethnic origins with both candidiasis and mycobacteriosis. The lack of functional RORγ and RORγT isoforms resulted in the absence of IL-17A/F-producing T cells in these individuals, probably accounting for their chronic candidiasis. Unexpectedly, leukocytes from RORγ- and RORγT-deficient individuals also displayed an impaired IFN-γ response to Mycobacterium. This principally reflected profoundly defective IFN-γ production by circulating γδ T cells and CD4(+)CCR6(+)CXCR3(+) αβ T cells. In humans, both mucocutaneous immunity to Candida and systemic immunity to Mycobacterium require RORγ, RORγT, or both." @default.
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- W1748436622 date "2015-08-07" @default.
- W1748436622 modified "2023-10-18" @default.
- W1748436622 title "Impairment of immunity to <i>Candida</i> and <i>Mycobacterium</i> in humans with bi-allelic <i>RORC</i> mutations" @default.
- W1748436622 cites W1487843912 @default.
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- W1748436622 cites W1972636814 @default.
- W1748436622 cites W1976026025 @default.
- W1748436622 cites W1976594342 @default.
- W1748436622 cites W1983879657 @default.
- W1748436622 cites W1984068087 @default.
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- W1748436622 cites W2018364329 @default.
- W1748436622 cites W2019737732 @default.
- W1748436622 cites W2022231331 @default.
- W1748436622 cites W2030017474 @default.
- W1748436622 cites W2034453891 @default.
- W1748436622 cites W2034605627 @default.
- W1748436622 cites W2043071551 @default.
- W1748436622 cites W2045348005 @default.
- W1748436622 cites W2049234640 @default.
- W1748436622 cites W2055444005 @default.
- W1748436622 cites W2056107229 @default.
- W1748436622 cites W2057877742 @default.
- W1748436622 cites W2061014664 @default.
- W1748436622 cites W2065252029 @default.
- W1748436622 cites W2066764643 @default.
- W1748436622 cites W2067850515 @default.
- W1748436622 cites W2072807977 @default.
- W1748436622 cites W2072859659 @default.
- W1748436622 cites W2073247934 @default.
- W1748436622 cites W2074640340 @default.
- W1748436622 cites W2075482744 @default.
- W1748436622 cites W2077352547 @default.
- W1748436622 cites W2077492907 @default.
- W1748436622 cites W2085723888 @default.
- W1748436622 cites W2091451666 @default.
- W1748436622 cites W2103433909 @default.
- W1748436622 cites W2103441770 @default.
- W1748436622 cites W2105306382 @default.