FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1748577606> ?p ?o ?g. }

• W1748577606 endingPage "901" @default.
• W1748577606 startingPage "893" @default.
• W1748577606 abstract "Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agonists and that, in a cohort of children with asthma living in a location prone to high levels of air pollution, expression of uniquely sensitive forms of TRPA1 may correlate with reduced asthma control. Variant forms of TRPA1 were constructed by mutating residues in known functional elements and corresponding to single-nucleotide polymorphisms in functional domains. TRPA1 activity was studied in transfected HEK-293 cells using allyl-isothiocynate, a model soluble electrophilic agonist; 3,5-ditert butylphenol, a soluble nonelectrophilic agonist and a component of diesel exhaust particles; and insoluble coal fly ash (CFA) particles. The N-terminal variants R3C and R58T exhibited greater, but not additive, activity with all three agonists. The ankyrin repeat domain-4 single nucleotide polymorphisms E179K and K186N exhibited decreased response to CFA. The predicted N-linked glycosylation site residues N747A and N753A exhibited decreased responses to CFA, which were not attributable to differences in cellular localization. The pore-loop residue R919Q was comparable to wild-type, whereas N954T was inactive to soluble agonists but not CFA. These data identify roles for ankyrin domain-4, cell surface N-linked glycans, and selected pore-loop domain residues in the activation of TRPA1 by insoluble particles. Furthermore, the R3C and R58T polymorphisms correlated with reduced asthma control for some children, which suggest that TRPA1 activity may modulate asthma, particularly among individuals living in locations prone to high levels of air pollution." @default.
• W1748577606 created "2016-06-24" @default.
• W1748577606 creator A5001492458 @default.
• W1748577606 creator A5007099944 @default.
• W1748577606 creator A5013863197 @default.
• W1748577606 creator A5014490581 @default.
• W1748577606 creator A5020018938 @default.
• W1748577606 creator A5036937141 @default.
• W1748577606 creator A5052769969 @default.
• W1748577606 creator A5067480196 @default.
• W1748577606 creator A5077978684 @default.
• W1748577606 creator A5081252847 @default.
• W1748577606 creator A5083610381 @default.
• W1748577606 creator A5086855627 @default.
• W1748577606 creator A5089499417 @default.
• W1748577606 date "2015-12-01" @default.
• W1748577606 modified "2023-10-06" @default.
• W1748577606 title "Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma" @default.
• W1748577606 cites W1543856987 @default.
• W1748577606 cites W1965751615 @default.
• W1748577606 cites W1973619060 @default.
• W1748577606 cites W1974213802 @default.
• W1748577606 cites W1976117410 @default.
• W1748577606 cites W1978128137 @default.
• W1748577606 cites W1982979580 @default.
• W1748577606 cites W1986242515 @default.
• W1748577606 cites W1987833374 @default.
• W1748577606 cites W1988717008 @default.
• W1748577606 cites W1995902693 @default.
• W1748577606 cites W1999470879 @default.
• W1748577606 cites W2002923710 @default.
• W1748577606 cites W2005893563 @default.
• W1748577606 cites W2006351130 @default.
• W1748577606 cites W2012402537 @default.
• W1748577606 cites W2020833052 @default.
• W1748577606 cites W2026532515 @default.
• W1748577606 cites W2038721368 @default.
• W1748577606 cites W2039558245 @default.
• W1748577606 cites W2041791443 @default.
• W1748577606 cites W2050886169 @default.
• W1748577606 cites W2057452021 @default.
• W1748577606 cites W2062978707 @default.
• W1748577606 cites W2073309758 @default.
• W1748577606 cites W2082071469 @default.
• W1748577606 cites W2085701176 @default.
• W1748577606 cites W2090260451 @default.
• W1748577606 cites W2101860685 @default.
• W1748577606 cites W2110383467 @default.
• W1748577606 cites W2126181026 @default.
• W1748577606 cites W2134637440 @default.
• W1748577606 cites W2141565041 @default.
• W1748577606 cites W2166976594 @default.
• W1748577606 cites W2185671382 @default.
• W1748577606 cites W2278324798 @default.
• W1748577606 cites W2601675613 @default.
• W1748577606 cites W4239218095 @default.
• W1748577606 doi "https://doi.org/10.1165/rcmb.2015-0086oc" @default.
• W1748577606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4742944" @default.
• W1748577606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26039217" @default.
• W1748577606 hasPublicationYear "2015" @default.
• W1748577606 type Work @default.
• W1748577606 sameAs 1748577606 @default.
• W1748577606 citedByCount "42" @default.
• W1748577606 countsByYear W17485776062016 @default.
• W1748577606 countsByYear W17485776062017 @default.
• W1748577606 countsByYear W17485776062018 @default.
• W1748577606 countsByYear W17485776062019 @default.
• W1748577606 countsByYear W17485776062020 @default.
• W1748577606 countsByYear W17485776062021 @default.
• W1748577606 countsByYear W17485776062022 @default.
• W1748577606 countsByYear W17485776062023 @default.
• W1748577606 crossrefType "journal-article" @default.
• W1748577606 hasAuthorship W1748577606A5001492458 @default.
• W1748577606 hasAuthorship W1748577606A5007099944 @default.
• W1748577606 hasAuthorship W1748577606A5013863197 @default.
• W1748577606 hasAuthorship W1748577606A5014490581 @default.
• W1748577606 hasAuthorship W1748577606A5020018938 @default.
• W1748577606 hasAuthorship W1748577606A5036937141 @default.
• W1748577606 hasAuthorship W1748577606A5052769969 @default.
• W1748577606 hasAuthorship W1748577606A5067480196 @default.
• W1748577606 hasAuthorship W1748577606A5077978684 @default.
• W1748577606 hasAuthorship W1748577606A5081252847 @default.
• W1748577606 hasAuthorship W1748577606A5083610381 @default.
• W1748577606 hasAuthorship W1748577606A5086855627 @default.
• W1748577606 hasAuthorship W1748577606A5089499417 @default.
• W1748577606 hasBestOaLocation W17485776062 @default.
• W1748577606 hasConcept C104317684 @default.
• W1748577606 hasConcept C113241181 @default.
• W1748577606 hasConcept C12554922 @default.
• W1748577606 hasConcept C155164980 @default.
• W1748577606 hasConcept C170493617 @default.
• W1748577606 hasConcept C174510640 @default.
• W1748577606 hasConcept C182800266 @default.
• W1748577606 hasConcept C185592680 @default.
• W1748577606 hasConcept C203014093 @default.
• W1748577606 hasConcept C2776914184 @default.
• W1748577606 hasConcept C2778938600 @default.
• W1748577606 hasConcept C55493867 @default.

• next