Matches in SemOpenAlex for { <https://semopenalex.org/work/W1748590633> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1748590633 endingPage "255" @default.
- W1748590633 startingPage "247" @default.
- W1748590633 abstract "The thyroid gland is a good organ for the study of genetic alterations in tumoural development and progress. The study of oncogenes and antigens of cellular proliferation is of interest.36 cases of thyroid adenomas, 58 papillary carcinomas, 32 follicular carcinomas, 2 anaplastic carcinomas and 12 medullary carcinomas were selected. Clinical and histological prognostic factors were studied and an immunohistochemical study with Ki-67 (MIB-1), p53, Bcl-2 and p21 RAS antibodies was performed.The proliferative rate Ki-67 (MIB-1) showed statistical differences in adenomas and follicular carcinomas. The p53 protein did not appear in adenomas, but was shown in those carcinomas with bigger histological dedifferentiation. A relationship was also established with greater age, larger size and progression of the tumour. The Bcl-2 protein was high in the normal thyroid, in the adenomas and in the carcinomas, decreasing in correlation with histological dedifferentiation, and totally disappearing in the anaplastic carcinomas. In medullary carcinomas its disappearance was correlated with mortality. The intense expression of the p21 RAS protein in papillary carcinomas is statistically correlated with advanced clinical studies.The differences in the proliferative rate between adenomas and follicular carcinomas can be of help in differential diagnosis. The p53 manifestation and the loss of the Bcl-2 expression are correlated with the histological redifferentiation process. An intense manifestation of p21 RAS in papillary carcinoma is correlated with tumoural progression." @default.
- W1748590633 created "2016-06-24" @default.
- W1748590633 creator A5013927332 @default.
- W1748590633 creator A5013962485 @default.
- W1748590633 creator A5037991450 @default.
- W1748590633 creator A5039345293 @default.
- W1748590633 creator A5049947500 @default.
- W1748590633 creator A5063385243 @default.
- W1748590633 creator A5083182593 @default.
- W1748590633 creator A5089494558 @default.
- W1748590633 date "2009-07-16" @default.
- W1748590633 modified "2023-09-22" @default.
- W1748590633 title "[Value of the expression of p21RAS, P53, Bcl-2 oncoproteins and Ki-67(MIB-1) antigen of cellular proliferation in the diagnosis and prognosis of thyroid tumors" @default.
- W1748590633 doi "https://doi.org/10.23938/assn.0775" @default.
- W1748590633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12886309" @default.
- W1748590633 hasPublicationYear "2009" @default.
- W1748590633 type Work @default.
- W1748590633 sameAs 1748590633 @default.
- W1748590633 citedByCount "1" @default.
- W1748590633 crossrefType "journal-article" @default.
- W1748590633 hasAuthorship W1748590633A5013927332 @default.
- W1748590633 hasAuthorship W1748590633A5013962485 @default.
- W1748590633 hasAuthorship W1748590633A5037991450 @default.
- W1748590633 hasAuthorship W1748590633A5039345293 @default.
- W1748590633 hasAuthorship W1748590633A5049947500 @default.
- W1748590633 hasAuthorship W1748590633A5063385243 @default.
- W1748590633 hasAuthorship W1748590633A5083182593 @default.
- W1748590633 hasAuthorship W1748590633A5089494558 @default.
- W1748590633 hasBestOaLocation W17485906331 @default.
- W1748590633 hasConcept C126322002 @default.
- W1748590633 hasConcept C142724271 @default.
- W1748590633 hasConcept C147483822 @default.
- W1748590633 hasConcept C187785154 @default.
- W1748590633 hasConcept C195121873 @default.
- W1748590633 hasConcept C203014093 @default.
- W1748590633 hasConcept C204232928 @default.
- W1748590633 hasConcept C2776667971 @default.
- W1748590633 hasConcept C2777428134 @default.
- W1748590633 hasConcept C2777546739 @default.
- W1748590633 hasConcept C2777751288 @default.
- W1748590633 hasConcept C2778981773 @default.
- W1748590633 hasConcept C2993294228 @default.
- W1748590633 hasConcept C502942594 @default.
- W1748590633 hasConcept C526584372 @default.
- W1748590633 hasConcept C71924100 @default.
- W1748590633 hasConceptScore W1748590633C126322002 @default.
- W1748590633 hasConceptScore W1748590633C142724271 @default.
- W1748590633 hasConceptScore W1748590633C147483822 @default.
- W1748590633 hasConceptScore W1748590633C187785154 @default.
- W1748590633 hasConceptScore W1748590633C195121873 @default.
- W1748590633 hasConceptScore W1748590633C203014093 @default.
- W1748590633 hasConceptScore W1748590633C204232928 @default.
- W1748590633 hasConceptScore W1748590633C2776667971 @default.
- W1748590633 hasConceptScore W1748590633C2777428134 @default.
- W1748590633 hasConceptScore W1748590633C2777546739 @default.
- W1748590633 hasConceptScore W1748590633C2777751288 @default.
- W1748590633 hasConceptScore W1748590633C2778981773 @default.
- W1748590633 hasConceptScore W1748590633C2993294228 @default.
- W1748590633 hasConceptScore W1748590633C502942594 @default.
- W1748590633 hasConceptScore W1748590633C526584372 @default.
- W1748590633 hasConceptScore W1748590633C71924100 @default.
- W1748590633 hasIssue "2" @default.
- W1748590633 hasLocation W17485906331 @default.
- W1748590633 hasLocation W17485906332 @default.
- W1748590633 hasOpenAccess W1748590633 @default.
- W1748590633 hasPrimaryLocation W17485906331 @default.
- W1748590633 hasRelatedWork W1970870200 @default.
- W1748590633 hasRelatedWork W1993405783 @default.
- W1748590633 hasRelatedWork W2074297518 @default.
- W1748590633 hasRelatedWork W2083679511 @default.
- W1748590633 hasRelatedWork W2143954873 @default.
- W1748590633 hasRelatedWork W2329173569 @default.
- W1748590633 hasRelatedWork W2364901446 @default.
- W1748590633 hasRelatedWork W2411858872 @default.
- W1748590633 hasRelatedWork W2413402529 @default.
- W1748590633 hasRelatedWork W3017019859 @default.
- W1748590633 hasVolume "23" @default.
- W1748590633 isParatext "false" @default.
- W1748590633 isRetracted "false" @default.
- W1748590633 magId "1748590633" @default.
- W1748590633 workType "article" @default.