FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1748711569> ?p ?o ?g. }

• W1748711569 endingPage "348" @default.
• W1748711569 startingPage "344" @default.
• W1748711569 abstract "Homologous recombination (HR) is central to the repair of double-strand DNA breaks that occur in S/G2 phases of the cell cycle. HR relies on the CtIP protein (Ctp1 in fission yeast, Sae2 in budding yeast) for resection of DNA ends, a key step in generating the 3′-DNA overhangs that are required for the HR strand-exchange reaction. Although much has been learned about the biological importance of CtIP in DNA repair, our mechanistic insight into its molecular functions remains incomplete. It has been recently discovered that CtIP and Ctp1 share a conserved tetrameric architecture that is mediated by their N-terminal domains and is critical for their function in HR. The specific arrangement of protein chains in the CtIP/Ctp1 tetramer indicates that an ability to bridge DNA ends might be an important feature of CtIP/Ctp1 function, establishing an intriguing similarity with the known ability of the MRE11-RAD50-NBS1 complex to link DNA ends. Although the exact mechanism of action remains to be elucidated, the remarkable evolutionary conservation of CtIP/Ctp1 tetramerisation clearly points to its crucial role in HR." @default.
• W1748711569 created "2016-06-24" @default.
• W1748711569 creator A5026016675 @default.
• W1748711569 creator A5069207835 @default.
• W1748711569 creator A5083333226 @default.
• W1748711569 date "2015-08-25" @default.
• W1748711569 modified "2023-09-27" @default.
• W1748711569 title "When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination" @default.
• W1748711569 cites W1592309404 @default.
• W1748711569 cites W1921575925 @default.
• W1748711569 cites W1943931237 @default.
• W1748711569 cites W1963779096 @default.
• W1748711569 cites W1964957202 @default.
• W1748711569 cites W1974706661 @default.
• W1748711569 cites W1979385111 @default.
• W1748711569 cites W1994375629 @default.
• W1748711569 cites W1996896283 @default.
• W1748711569 cites W2011902133 @default.
• W1748711569 cites W2017275209 @default.
• W1748711569 cites W2019239618 @default.
• W1748711569 cites W2021870890 @default.
• W1748711569 cites W2033651349 @default.
• W1748711569 cites W2040036630 @default.
• W1748711569 cites W2040838669 @default.
• W1748711569 cites W2048728990 @default.
• W1748711569 cites W2050987046 @default.
• W1748711569 cites W2057910747 @default.
• W1748711569 cites W2068668324 @default.
• W1748711569 cites W2068946493 @default.
• W1748711569 cites W2075477236 @default.
• W1748711569 cites W2080313089 @default.
• W1748711569 cites W2088601000 @default.
• W1748711569 cites W2108555564 @default.
• W1748711569 cites W2108720210 @default.
• W1748711569 cites W2109215807 @default.
• W1748711569 cites W2114404734 @default.
• W1748711569 cites W2117238796 @default.
• W1748711569 cites W2144609528 @default.
• W1748711569 cites W2158387976 @default.
• W1748711569 cites W2163787826 @default.
• W1748711569 cites W2170122994 @default.
• W1748711569 doi "https://doi.org/10.1080/19491034.2015.1086050" @default.
• W1748711569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4915501" @default.
• W1748711569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26305173" @default.
• W1748711569 hasPublicationYear "2015" @default.
• W1748711569 type Work @default.
• W1748711569 sameAs 1748711569 @default.
• W1748711569 citedByCount "8" @default.
• W1748711569 countsByYear W17487115692017 @default.
• W1748711569 countsByYear W17487115692018 @default.
• W1748711569 countsByYear W17487115692019 @default.
• W1748711569 countsByYear W17487115692020 @default.
• W1748711569 countsByYear W17487115692021 @default.
• W1748711569 countsByYear W17487115692023 @default.
• W1748711569 crossrefType "journal-article" @default.
• W1748711569 hasAuthorship W1748711569A5026016675 @default.
• W1748711569 hasAuthorship W1748711569A5069207835 @default.
• W1748711569 hasAuthorship W1748711569A5083333226 @default.
• W1748711569 hasBestOaLocation W17487115691 @default.
• W1748711569 hasConcept C102744134 @default.
• W1748711569 hasConcept C104317684 @default.
• W1748711569 hasConcept C134935766 @default.
• W1748711569 hasConcept C143425029 @default.
• W1748711569 hasConcept C181199279 @default.
• W1748711569 hasConcept C2775984157 @default.
• W1748711569 hasConcept C2778886173 @default.
• W1748711569 hasConcept C2779012473 @default.
• W1748711569 hasConcept C54355233 @default.
• W1748711569 hasConcept C552990157 @default.
• W1748711569 hasConcept C55493867 @default.
• W1748711569 hasConcept C70721500 @default.
• W1748711569 hasConcept C86339819 @default.
• W1748711569 hasConcept C86803240 @default.
• W1748711569 hasConcept C94966510 @default.
• W1748711569 hasConcept C95444343 @default.
• W1748711569 hasConceptScore W1748711569C102744134 @default.
• W1748711569 hasConceptScore W1748711569C104317684 @default.
• W1748711569 hasConceptScore W1748711569C134935766 @default.
• W1748711569 hasConceptScore W1748711569C143425029 @default.
• W1748711569 hasConceptScore W1748711569C181199279 @default.
• W1748711569 hasConceptScore W1748711569C2775984157 @default.
• W1748711569 hasConceptScore W1748711569C2778886173 @default.
• W1748711569 hasConceptScore W1748711569C2779012473 @default.
• W1748711569 hasConceptScore W1748711569C54355233 @default.
• W1748711569 hasConceptScore W1748711569C552990157 @default.
• W1748711569 hasConceptScore W1748711569C55493867 @default.
• W1748711569 hasConceptScore W1748711569C70721500 @default.
• W1748711569 hasConceptScore W1748711569C86339819 @default.
• W1748711569 hasConceptScore W1748711569C86803240 @default.
• W1748711569 hasConceptScore W1748711569C94966510 @default.
• W1748711569 hasConceptScore W1748711569C95444343 @default.
• W1748711569 hasIssue "5" @default.
• W1748711569 hasLocation W17487115691 @default.
• W1748711569 hasLocation W17487115692 @default.
• W1748711569 hasLocation W17487115693 @default.
• W1748711569 hasLocation W17487115694 @default.
• W1748711569 hasLocation W17487115695 @default.
• W1748711569 hasOpenAccess W1748711569 @default.

• next