Matches in SemOpenAlex for { <https://semopenalex.org/work/W1749207645> ?p ?o ?g. }
- W1749207645 endingPage "2318" @default.
- W1749207645 startingPage "2308" @default.
- W1749207645 abstract "We found recently that TNF-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible-14 (Fn14) by virtue of their strong capability to reduce the freely available cytoplasmic pool of TNFR-associated factor (TRAF)2 and cellular inhibitors of apoptosis (cIAPs) antagonize the functions of these molecules in TNFR1 signaling, resulting in sensitization for apoptosis and inhibition of classical NF-κB signaling. In this study, we demonstrate that priming of cells with TWEAK also interferes with activation of the classical NF-κB pathway by CD40. Likewise, there was strong inhibition of CD40 ligand (CD40L)-induced activation of MAPKs in TWEAK-primed cells. FACS analysis and CD40L binding studies revealed unchanged CD40 expression and normal CD40L-CD40 interaction in TWEAK-primed cells. CD40L immunoprecipitates, however, showed severely reduced amounts of CD40 and CD40-associated proteins, indicating impaired formation or reduced stability of CD40L-CD40 signaling complexes. The previously described inhibitory effect of TWEAK on TNFR1 signaling has been traced back to reduced activity of the TNFR1-associated TRAF2-cIAP1/2 ubiquitinase complex and did not affect the stability of the immunoprecipitable TNFR1 receptor complex. Thus, the inhibitory effect of TWEAK on CD40 signaling must be based at least partly on other mechanisms. In line with this, signaling by the CD40-related TRAF2-interacting receptor TNFR2 was also attenuated but still immunoprecipitable in TWEAK-primed cells. Collectively, we show that Fn14 activation by soluble TWEAK impairs CD40L-CD40 signaling complex formation and inhibits CD40 signaling and thus identify the Fn14-TWEAK system as a potential novel regulator of CD40-related cellular functions." @default.
- W1749207645 created "2016-06-24" @default.
- W1749207645 creator A5014957210 @default.
- W1749207645 creator A5016912851 @default.
- W1749207645 creator A5028834949 @default.
- W1749207645 creator A5041527718 @default.
- W1749207645 creator A5044661896 @default.
- W1749207645 creator A5052651531 @default.
- W1749207645 creator A5053079637 @default.
- W1749207645 creator A5072565682 @default.
- W1749207645 creator A5075839626 @default.
- W1749207645 creator A5083726707 @default.
- W1749207645 date "2013-08-05" @default.
- W1749207645 modified "2023-10-12" @default.
- W1749207645 title "TWEAK Inhibits TRAF2-Mediated CD40 Signaling by Destabilization of CD40 Signaling Complexes" @default.
- W1749207645 cites W1520421339 @default.
- W1749207645 cites W1531917019 @default.
- W1749207645 cites W1547549972 @default.
- W1749207645 cites W1567453654 @default.
- W1749207645 cites W1585721957 @default.
- W1749207645 cites W1778624427 @default.
- W1749207645 cites W1793898094 @default.
- W1749207645 cites W1957540688 @default.
- W1749207645 cites W1964445506 @default.
- W1749207645 cites W1983159021 @default.
- W1749207645 cites W1987201681 @default.
- W1749207645 cites W1987600613 @default.
- W1749207645 cites W1998162712 @default.
- W1749207645 cites W1999308213 @default.
- W1749207645 cites W2005176562 @default.
- W1749207645 cites W2012060832 @default.
- W1749207645 cites W2017390384 @default.
- W1749207645 cites W2023002754 @default.
- W1749207645 cites W2029871546 @default.
- W1749207645 cites W2030151880 @default.
- W1749207645 cites W2034734532 @default.
- W1749207645 cites W2035999971 @default.
- W1749207645 cites W2036105610 @default.
- W1749207645 cites W2037036977 @default.
- W1749207645 cites W2040139955 @default.
- W1749207645 cites W2051203952 @default.
- W1749207645 cites W2057049237 @default.
- W1749207645 cites W2059259037 @default.
- W1749207645 cites W2063881294 @default.
- W1749207645 cites W2064408054 @default.
- W1749207645 cites W2068839290 @default.
- W1749207645 cites W2069996982 @default.
- W1749207645 cites W2070968944 @default.
- W1749207645 cites W2074664467 @default.
- W1749207645 cites W2079340063 @default.
- W1749207645 cites W2084047756 @default.
- W1749207645 cites W2095330800 @default.
- W1749207645 cites W2097916320 @default.
- W1749207645 cites W2100682112 @default.
- W1749207645 cites W2104294370 @default.
- W1749207645 cites W2107312134 @default.
- W1749207645 cites W2107603225 @default.
- W1749207645 cites W2112819410 @default.
- W1749207645 cites W2122582904 @default.
- W1749207645 cites W2134706781 @default.
- W1749207645 cites W2135009937 @default.
- W1749207645 cites W2136913761 @default.
- W1749207645 cites W2145429473 @default.
- W1749207645 cites W2147795445 @default.
- W1749207645 cites W2152644565 @default.
- W1749207645 cites W2152646879 @default.
- W1749207645 cites W2153445234 @default.
- W1749207645 cites W2155189607 @default.
- W1749207645 cites W2158806968 @default.
- W1749207645 cites W2160229740 @default.
- W1749207645 cites W2167935306 @default.
- W1749207645 doi "https://doi.org/10.4049/jimmunol.1202899" @default.
- W1749207645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23918987" @default.
- W1749207645 hasPublicationYear "2013" @default.
- W1749207645 type Work @default.
- W1749207645 sameAs 1749207645 @default.
- W1749207645 citedByCount "17" @default.
- W1749207645 countsByYear W17492076452013 @default.
- W1749207645 countsByYear W17492076452014 @default.
- W1749207645 countsByYear W17492076452015 @default.
- W1749207645 countsByYear W17492076452016 @default.
- W1749207645 countsByYear W17492076452017 @default.
- W1749207645 countsByYear W17492076452018 @default.
- W1749207645 countsByYear W17492076452019 @default.
- W1749207645 countsByYear W17492076452020 @default.
- W1749207645 countsByYear W17492076452023 @default.
- W1749207645 crossrefType "journal-article" @default.
- W1749207645 hasAuthorship W1749207645A5014957210 @default.
- W1749207645 hasAuthorship W1749207645A5016912851 @default.
- W1749207645 hasAuthorship W1749207645A5028834949 @default.
- W1749207645 hasAuthorship W1749207645A5041527718 @default.
- W1749207645 hasAuthorship W1749207645A5044661896 @default.
- W1749207645 hasAuthorship W1749207645A5052651531 @default.
- W1749207645 hasAuthorship W1749207645A5053079637 @default.
- W1749207645 hasAuthorship W1749207645A5072565682 @default.
- W1749207645 hasAuthorship W1749207645A5075839626 @default.
- W1749207645 hasAuthorship W1749207645A5083726707 @default.
- W1749207645 hasBestOaLocation W17492076451 @default.