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- W1749456450 abstract "This study examined the effect of tiletamine-zolazepam (TZ) on the isoflurane (ISO) MAC in goats.Six adult wethers (37 ± 13 kg) were used in the study. Anesthesia was induced with ISO delivered via a face mask. Goats were intubated and ventilated to normocapnia. ISO was carried in oxygen (3 L minute−1). End-tidal (ET) gases were measured using a calibrated infrared gas analyzer (Criticare 1100). Samples were drawn from the distal end of the endotracheal tube. Each goat was studied on six occasions, at weekly intervals, using a Latin Square design, and at each study period, received one of the following intravenous treatments in random order (TZ 0.55, 1.1, 2.2, 4.4, or 8.8 mg kg−1, or saline). MAC was determined by clamping a claw for 60 seconds or until purposeful movement occurred. MAC was defined as the mean ISO concentrations at which movement did and did not occur. Body temperature was maintained in the normal range (100.8–102.3° F) using a heating pad. One hour was allowed before the baseline MAC (MAC1) was determined in duplicate. Following this, a treatment was administered and a single determination of MAC was performed (MAC2). End tidal ISO concentration was held constant for 20 minutes prior to each testing. Data were analyzed, using a mixed-model anova, to determine the effect of treatment on the difference in MAC (MAC1-MAC2), and the percentage change in MAC. Differences in MAC were fitted as dependent variables, and treatment and time as independent variables. Goats were included as a random variable in the model.The mean MAC1, of all groups, was 1.3 ± 0.18%. Saline did not affect MAC. For all doses of TZ, the difference in MAC was significant (p < 0.0001). The mean percentage decrease (p < 0.0001) was 29% (0.55 mg kg−1), 43% (1.1 mg kg−1), 51% (2.2 mg kg−1), 65% (4.4 mg kg−1) and 77% (8.8 mg kg−1). The percentage difference in MAC was not affected by the order of treatment or the time taken (78 ± 21 minutes) to determine MAC2.The study indicates that, in goats, TZ decreases ISO MAC in a dose-dependent fashion." @default.
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- W1749456450 date "2001-04-01" @default.
- W1749456450 modified "2023-10-18" @default.
- W1749456450 title "The effect of tiletamine-zolazepam on isoflurane minimum alveolar concentration in goats" @default.
- W1749456450 doi "https://doi.org/10.1046/j.1467-2987.2001.temp.doc.x-i6" @default.
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