FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1749561343> ?p ?o ?g. }

• W1749561343 endingPage "879" @default.
• W1749561343 startingPage "870" @default.
• W1749561343 abstract "Objectives/Hypothesis To describe the management and outcomes of Fanconi anemia (FA) patients with head and neck squamous cell carcinoma. Study Design Cohort study. Methods Demographic information, prognostic factors, therapeutic management, and survival outcomes for FA patients enrolled in the International Fanconi Anemia Registry who developed head and neck squamous cell carcinoma (HNSCC) were analyzed. Results Thirty‐five FA patients were diagnosed with HNSCC at a mean age of 32 years. The most common site of primary cancer was the oral cavity (26 of 35, 74%). Thirty patients underwent surgical resection of the cancer. Sixteen patients received radiation therapy with an average radiation dose of 5,050 cGy. The most common toxicities were high‐grade mucositis (9 of 16, 56%), hematologic abnormalities (8 of 16, 50%), and dysphagia (8 of 16, 50%). Three patients received conventional chemotherapy and had significant complications, whereas three patients who received targeted chemotherapy with cetuximab had fewer toxicities. The 5‐year overall survival rate was 39%, with a cause‐specific survival rate of 47%. Conclusions Fanconi anemia patients have a high risk of developing aggressive HNSCC at an early age. Fanconi anemia patients can tolerate complex ablative and reconstructive surgeries, but careful postoperative care is required to reduce morbidity. The treatment of FA‐associated HNSCC is difficult secondary to the poor tolerance of radiation and chemotherapy. However, radiation should be used for high‐risk cancers due to the poor survival in these patients. Level of Evidence 4. Laryngoscope , 126:870–879, 2016" @default.
• W1749561343 created "2016-06-24" @default.
• W1749561343 creator A5011288653 @default.
• W1749561343 creator A5023841821 @default.
• W1749561343 creator A5025488302 @default.
• W1749561343 creator A5068889097 @default.
• W1749561343 creator A5070048389 @default.
• W1749561343 creator A5072523852 @default.
• W1749561343 creator A5073054152 @default.
• W1749561343 creator A5086677527 @default.
• W1749561343 creator A5089560697 @default.
• W1749561343 date "2015-10-20" @default.
• W1749561343 modified "2023-10-16" @default.
• W1749561343 title "Natural history and management of Fanconi anemia patients with head and neck cancer: A 10-year follow-up" @default.
• W1749561343 cites W1540752041 @default.
• W1749561343 cites W1549538719 @default.
• W1749561343 cites W1562232013 @default.
• W1749561343 cites W1583606054 @default.
• W1749561343 cites W16620579 @default.
• W1749561343 cites W1940231728 @default.
• W1749561343 cites W1965889558 @default.
• W1749561343 cites W1966160283 @default.
• W1749561343 cites W1967208836 @default.
• W1749561343 cites W1968245004 @default.
• W1749561343 cites W1981838265 @default.
• W1749561343 cites W1986030260 @default.
• W1749561343 cites W1986890123 @default.
• W1749561343 cites W1991841649 @default.
• W1749561343 cites W2000067413 @default.
• W1749561343 cites W2004125597 @default.
• W1749561343 cites W2011291904 @default.
• W1749561343 cites W2013986889 @default.
• W1749561343 cites W2015805015 @default.
• W1749561343 cites W2022775755 @default.
• W1749561343 cites W2030912934 @default.
• W1749561343 cites W2038811166 @default.
• W1749561343 cites W2044292152 @default.
• W1749561343 cites W2048949519 @default.
• W1749561343 cites W2049689768 @default.
• W1749561343 cites W2053704077 @default.
• W1749561343 cites W2059920998 @default.
• W1749561343 cites W2061215860 @default.
• W1749561343 cites W2062073391 @default.
• W1749561343 cites W2070142967 @default.
• W1749561343 cites W2074529613 @default.
• W1749561343 cites W2096380982 @default.
• W1749561343 cites W2096995751 @default.
• W1749561343 cites W2099590148 @default.
• W1749561343 cites W2111499574 @default.
• W1749561343 cites W2114907977 @default.
• W1749561343 cites W2121178654 @default.
• W1749561343 cites W2121681287 @default.
• W1749561343 cites W2129663487 @default.
• W1749561343 cites W2139348853 @default.
• W1749561343 cites W2147774152 @default.
• W1749561343 cites W2164885933 @default.
• W1749561343 cites W2167464044 @default.
• W1749561343 cites W2316496816 @default.
• W1749561343 doi "https://doi.org/10.1002/lary.25726" @default.
• W1749561343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4803627" @default.
• W1749561343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26484938" @default.
• W1749561343 hasPublicationYear "2015" @default.
• W1749561343 type Work @default.
• W1749561343 sameAs 1749561343 @default.
• W1749561343 citedByCount "67" @default.
• W1749561343 countsByYear W17495613432015 @default.
• W1749561343 countsByYear W17495613432016 @default.
• W1749561343 countsByYear W17495613432017 @default.
• W1749561343 countsByYear W17495613432018 @default.
• W1749561343 countsByYear W17495613432019 @default.
• W1749561343 countsByYear W17495613432020 @default.
• W1749561343 countsByYear W17495613432021 @default.
• W1749561343 countsByYear W17495613432022 @default.
• W1749561343 countsByYear W17495613432023 @default.
• W1749561343 crossrefType "journal-article" @default.
• W1749561343 hasAuthorship W1749561343A5011288653 @default.
• W1749561343 hasAuthorship W1749561343A5023841821 @default.
• W1749561343 hasAuthorship W1749561343A5025488302 @default.
• W1749561343 hasAuthorship W1749561343A5068889097 @default.
• W1749561343 hasAuthorship W1749561343A5070048389 @default.
• W1749561343 hasAuthorship W1749561343A5072523852 @default.
• W1749561343 hasAuthorship W1749561343A5073054152 @default.
• W1749561343 hasAuthorship W1749561343A5086677527 @default.
• W1749561343 hasAuthorship W1749561343A5089560697 @default.
• W1749561343 hasBestOaLocation W17495613432 @default.
• W1749561343 hasConcept C104317684 @default.
• W1749561343 hasConcept C121608353 @default.
• W1749561343 hasConcept C126322002 @default.
• W1749561343 hasConcept C134935766 @default.
• W1749561343 hasConcept C141071460 @default.
• W1749561343 hasConcept C143998085 @default.
• W1749561343 hasConcept C185592680 @default.
• W1749561343 hasConcept C2776283816 @default.
• W1749561343 hasConcept C2776530083 @default.
• W1749561343 hasConcept C2776833033 @default.
• W1749561343 hasConcept C2778124228 @default.
• W1749561343 hasConcept C2778248108 @default.
• W1749561343 hasConcept C2778496288 @default.

• next