FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1749742432> ?p ?o ?g. }

• W1749742432 endingPage "5536" @default.
• W1749742432 startingPage "5528" @default.
• W1749742432 abstract "Abstract The antiviral activity of HIV-specific CTL is not equally potent but rather is dependent on their specificity. But what characteristic of targeted peptides influences CTL antiviral activity remains elusive. We addressed this issue based on HLA-B35-restricted CTLs specific for two overlapping immunodominant Nef epitopes, VY8 (VPLRPMTY) and RY11 (RPQVPLRPMTY). VY8-specific CTLs were more potently cytotoxic toward HIV-infected primary CD4+ cells than RY11-specific CTLs. Reconstruction of their TCR revealed no substantial difference in their functional avidity toward cognate Ags. Instead, the decay analysis of the peptide-MHC complex (pMHC) revealed that the VY8/HLA-B35 complex could maintain its capacity to sensitize T cells much longer than its RY11 counterpart. Corroboratively, the introduction of a mutation in the epitopes that substantially delayed pMHC decay rendered Nef-expressing target cells more susceptible to CTL killing. Moreover, by using differential scanning calorimetry and circular dichroism analyses, we found that the susceptible pMHC ligands for CTL killing showed interdependent and cooperative, rather than separate or sequential, transitions within their heterotrimer components under the thermally induced unfolding process. Collectively, our results highlight the significant effects of intrinsic peptide factors that support cooperative thermodynamics within pMHC on the efficient CTL killing of HIV-infected cells, thus providing us better insight into vaccine design." @default.
• W1749742432 created "2016-06-24" @default.
• W1749742432 creator A5041242514 @default.
• W1749742432 creator A5069707790 @default.
• W1749742432 creator A5071010313 @default.
• W1749742432 creator A5072979871 @default.
• W1749742432 creator A5078546233 @default.
• W1749742432 date "2009-05-01" @default.
• W1749742432 modified "2023-10-02" @default.
• W1749742432 title "Impact of Intrinsic Cooperative Thermodynamics of Peptide-MHC Complexes on Antiviral Activity of HIV-Specific CTL" @default.
• W1749742432 cites W1487106910 @default.
• W1749742432 cites W1502370146 @default.
• W1749742432 cites W1565230971 @default.
• W1749742432 cites W1623595668 @default.
• W1749742432 cites W1650684965 @default.
• W1749742432 cites W1675195038 @default.
• W1749742432 cites W1714666634 @default.
• W1749742432 cites W1772325158 @default.
• W1749742432 cites W1857725337 @default.
• W1749742432 cites W1900590876 @default.
• W1749742432 cites W1922646908 @default.
• W1749742432 cites W1923210470 @default.
• W1749742432 cites W1927402999 @default.
• W1749742432 cites W1968380257 @default.
• W1749742432 cites W1971287207 @default.
• W1749742432 cites W1978436252 @default.
• W1749742432 cites W1985859196 @default.
• W1749742432 cites W1986811829 @default.
• W1749742432 cites W1988060503 @default.
• W1749742432 cites W1992598287 @default.
• W1749742432 cites W2001081076 @default.
• W1749742432 cites W2001815433 @default.
• W1749742432 cites W2002674986 @default.
• W1749742432 cites W2005274005 @default.
• W1749742432 cites W2013851631 @default.
• W1749742432 cites W2024130010 @default.
• W1749742432 cites W2031352213 @default.
• W1749742432 cites W2035852466 @default.
• W1749742432 cites W2039456204 @default.
• W1749742432 cites W2046653068 @default.
• W1749742432 cites W2048931419 @default.
• W1749742432 cites W2048999843 @default.
• W1749742432 cites W2056651081 @default.
• W1749742432 cites W2074513702 @default.
• W1749742432 cites W2076055222 @default.
• W1749742432 cites W2079280846 @default.
• W1749742432 cites W2079542677 @default.
• W1749742432 cites W2084492053 @default.
• W1749742432 cites W2086274485 @default.
• W1749742432 cites W2092368847 @default.
• W1749742432 cites W2098822919 @default.
• W1749742432 cites W2099182602 @default.
• W1749742432 cites W2103308308 @default.
• W1749742432 cites W2112601022 @default.
• W1749742432 cites W2121037457 @default.
• W1749742432 cites W2126995823 @default.
• W1749742432 cites W2128407908 @default.
• W1749742432 cites W2142774061 @default.
• W1749742432 cites W2145476394 @default.
• W1749742432 cites W2145847351 @default.
• W1749742432 cites W2147134928 @default.
• W1749742432 cites W2155450765 @default.
• W1749742432 cites W2158240501 @default.
• W1749742432 cites W2159877190 @default.
• W1749742432 cites W2162457545 @default.
• W1749742432 cites W2169237989 @default.
• W1749742432 cites W2169404894 @default.
• W1749742432 cites W4230821365 @default.
• W1749742432 doi "https://doi.org/10.4049/jimmunol.0803471" @default.
• W1749742432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19380801" @default.
• W1749742432 hasPublicationYear "2009" @default.
• W1749742432 type Work @default.
• W1749742432 sameAs 1749742432 @default.
• W1749742432 citedByCount "15" @default.
• W1749742432 countsByYear W17497424322012 @default.
• W1749742432 countsByYear W17497424322013 @default.
• W1749742432 countsByYear W17497424322014 @default.
• W1749742432 countsByYear W17497424322015 @default.
• W1749742432 countsByYear W17497424322017 @default.
• W1749742432 crossrefType "journal-article" @default.
• W1749742432 hasAuthorship W1749742432A5041242514 @default.
• W1749742432 hasAuthorship W1749742432A5069707790 @default.
• W1749742432 hasAuthorship W1749742432A5071010313 @default.
• W1749742432 hasAuthorship W1749742432A5072979871 @default.
• W1749742432 hasAuthorship W1749742432A5078546233 @default.
• W1749742432 hasBestOaLocation W17497424321 @default.
• W1749742432 hasConcept C12554922 @default.
• W1749742432 hasConcept C133571119 @default.
• W1749742432 hasConcept C147483822 @default.
• W1749742432 hasConcept C147969180 @default.
• W1749742432 hasConcept C154317977 @default.
• W1749742432 hasConcept C159047783 @default.
• W1749742432 hasConcept C179223381 @default.
• W1749742432 hasConcept C185592680 @default.
• W1749742432 hasConcept C195616568 @default.
• W1749742432 hasConcept C202751555 @default.
• W1749742432 hasConcept C203014093 @default.
• W1749742432 hasConcept C207936829 @default.

• next