FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1749969555> ?p ?o ?g. }

• W1749969555 endingPage "218" @default.
• W1749969555 startingPage "210" @default.
• W1749969555 abstract "The growth properties of hamster cells transformed by wild-type Simian virus 40 (SV40), by early SV40 temperature-sensitive mutants of the A complementation group, and by spontaneous revertants of these mutants were studied. All of the tsA mutant-transformed cells were temperature sensitive in their ability to form clones in soft agar and on monolayers of normal cells except for CHLA-30L1, which was not temperature sensitive in the latter property. All cells transformed by stable revertants of well-characterized tsA mutants possessed certain growth properties in common with wild-type-transformed cells at both temperatures. Virus rescued from tsA transformants including CHLA30L1 was temperature sensitive for viral DNA replication, whereas that rescued from revertant and wild-type transformants was not thermolabile in this regard. T antigen present in crude extracts of tsA-transformed cells including CHLA30L1, grown at 33 degreeC, was temperature sensitive by in vitro immunoassay, whereas that from wild-type-transformed cells was relatively stable. T antigen from revertant transformants was more stable than the tsA protein. Partially purified T antigen from revertant-transformed cells was nearly as stable as wild-type antigen in its ability to bind DNA after heating at 44 degrees C, whereas T antigen from tsA30 mutant-transformed cells was relatively thermolabile. These results further indicate that T antigen is a product of the SV40 A gene. Significantly more T antigen was found in extracts of CHLA30L1 grown to high density at the nonpermissive temperature than in any other tsA-transformed cell similarly grown. This is consistent with the suggestion that the amount of T antigen synthesized in CHLA30L1 is large enoughto allow partial expression of the transformed phenotype at the restrictive temperature. Alternatively, the increase in T antigen concentration may be secondary to one or more genetic alterations that independently affect the transformed phenotype of these cells." @default.
• W1749969555 created "2016-06-24" @default.
• W1749969555 creator A5029032924 @default.
• W1749969555 creator A5044347888 @default.
• W1749969555 creator A5056687452 @default.
• W1749969555 creator A5071011669 @default.
• W1749969555 date "1977-04-01" @default.
• W1749969555 modified "2023-09-24" @default.
• W1749969555 title "Biological and biochemical studies of cells transformed by simian virus 40 temperature-sensitive gene A mutants and A mutant revertants" @default.
• W1749969555 cites W1491225232 @default.
• W1749969555 cites W1515248712 @default.
• W1749969555 cites W1533966528 @default.
• W1749969555 cites W1543627789 @default.
• W1749969555 cites W1598730195 @default.
• W1749969555 cites W1606446547 @default.
• W1749969555 cites W1646315724 @default.
• W1749969555 cites W1676800125 @default.
• W1749969555 cites W1777882411 @default.
• W1749969555 cites W1835796364 @default.
• W1749969555 cites W1941365063 @default.
• W1749969555 cites W1947261073 @default.
• W1749969555 cites W1967446284 @default.
• W1749969555 cites W1970754962 @default.
• W1749969555 cites W1993719426 @default.
• W1749969555 cites W2000095208 @default.
• W1749969555 cites W2000869596 @default.
• W1749969555 cites W2002763163 @default.
• W1749969555 cites W2025513247 @default.
• W1749969555 cites W2031875867 @default.
• W1749969555 cites W2049073646 @default.
• W1749969555 cites W2052885238 @default.
• W1749969555 cites W2064000577 @default.
• W1749969555 cites W2071951498 @default.
• W1749969555 cites W2078287000 @default.
• W1749969555 cites W2081938019 @default.
• W1749969555 cites W2083254800 @default.
• W1749969555 cites W2090784961 @default.
• W1749969555 cites W2101119724 @default.
• W1749969555 cites W2147902159 @default.
• W1749969555 cites W2150107072 @default.
• W1749969555 cites W2317322771 @default.
• W1749969555 cites W2317884017 @default.
• W1749969555 cites W2320670585 @default.
• W1749969555 doi "https://doi.org/10.1128/jvi.22.1.210-218.1977" @default.
• W1749969555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/515702" @default.
• W1749969555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/192912" @default.
• W1749969555 hasPublicationYear "1977" @default.
• W1749969555 type Work @default.
• W1749969555 sameAs 1749969555 @default.
• W1749969555 citedByCount "44" @default.
• W1749969555 crossrefType "journal-article" @default.
• W1749969555 hasAuthorship W1749969555A5029032924 @default.
• W1749969555 hasAuthorship W1749969555A5044347888 @default.
• W1749969555 hasAuthorship W1749969555A5056687452 @default.
• W1749969555 hasAuthorship W1749969555A5071011669 @default.
• W1749969555 hasBestOaLocation W17499695551 @default.
• W1749969555 hasConcept C104317684 @default.
• W1749969555 hasConcept C143065580 @default.
• W1749969555 hasConcept C147483822 @default.
• W1749969555 hasConcept C153911025 @default.
• W1749969555 hasConcept C159047783 @default.
• W1749969555 hasConcept C181199279 @default.
• W1749969555 hasConcept C188082640 @default.
• W1749969555 hasConcept C207583985 @default.
• W1749969555 hasConcept C2522874641 @default.
• W1749969555 hasConcept C2779155592 @default.
• W1749969555 hasConcept C54009773 @default.
• W1749969555 hasConcept C54355233 @default.
• W1749969555 hasConcept C55493867 @default.
• W1749969555 hasConcept C81885089 @default.
• W1749969555 hasConcept C86803240 @default.
• W1749969555 hasConceptScore W1749969555C104317684 @default.
• W1749969555 hasConceptScore W1749969555C143065580 @default.
• W1749969555 hasConceptScore W1749969555C147483822 @default.
• W1749969555 hasConceptScore W1749969555C153911025 @default.
• W1749969555 hasConceptScore W1749969555C159047783 @default.
• W1749969555 hasConceptScore W1749969555C181199279 @default.
• W1749969555 hasConceptScore W1749969555C188082640 @default.
• W1749969555 hasConceptScore W1749969555C207583985 @default.
• W1749969555 hasConceptScore W1749969555C2522874641 @default.
• W1749969555 hasConceptScore W1749969555C2779155592 @default.
• W1749969555 hasConceptScore W1749969555C54009773 @default.
• W1749969555 hasConceptScore W1749969555C54355233 @default.
• W1749969555 hasConceptScore W1749969555C55493867 @default.
• W1749969555 hasConceptScore W1749969555C81885089 @default.
• W1749969555 hasConceptScore W1749969555C86803240 @default.
• W1749969555 hasIssue "1" @default.
• W1749969555 hasLocation W17499695551 @default.
• W1749969555 hasLocation W17499695552 @default.
• W1749969555 hasLocation W17499695553 @default.
• W1749969555 hasOpenAccess W1749969555 @default.
• W1749969555 hasPrimaryLocation W17499695551 @default.
• W1749969555 hasRelatedWork W1551229083 @default.
• W1749969555 hasRelatedWork W1554885052 @default.
• W1749969555 hasRelatedWork W1749969555 @default.
• W1749969555 hasRelatedWork W1959686341 @default.
• W1749969555 hasRelatedWork W2009464217 @default.
• W1749969555 hasRelatedWork W2029879405 @default.

• next