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• W1750203119 endingPage "372" @default.
• W1750203119 startingPage "364" @default.
• W1750203119 abstract "Summary The biologically active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (calcitriol), is a potent modulator of the immune response. We have shown previously that calcitriol modulates the immunoglobulin response in vitro and in vivo in mice and humans. To analyse the underlying molecular mechanisms we studied whether calcitriol-primed B cells modulate T cell activation and function. Human B cells were stimulated with anti-CD40 and interleukin (IL)-4 in the presence of increasing concentrations of calcitriol. After removal of calcitriol, primed B cells were co-cultured with autologous CD4+T cells; the B cell phenotype T cell activation and their consecutive cytokine production were also assessed. Naive T cells co-cultured with calcitriol-primed naive B cells showed a reduced expansion, nuclear factor of activated T cells, cytoplasmic 2 (NFATc2) expression and cytokine production upon restimulation. CD86 expression on B cells after calcitriol priming was identified as an underlying mechanism, as T cell activation and expansion was rescued by activating anti-CD28 antibodies. Our data indicate that calcitriol-primed B cells display an impaired capacity to activate T cells. Taken together, we identified a novel B cell-dependent vitamin D immune regulatory mechanism, namely by decreased co-stimulation of calcitriol-primed B cells." @default.
• W1750203119 created "2016-06-24" @default.
• W1750203119 creator A5005683951 @default.
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• W1750203119 date "2014-10-01" @default.
• W1750203119 modified "2023-10-12" @default.
• W1750203119 title "Impaired T cell activation and cytokine production by calcitriol-primed human B cells" @default.
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• W1750203119 doi "https://doi.org/10.1111/cei.12406" @default.
• W1750203119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4233385" @default.
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• W1750203119 hasPublicationYear "2014" @default.
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