FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750204334> ?p ?o ?g. }

• W1750204334 abstract "The addition of O-linked N-acetylglucosamine (O-GlcNAc) on serine or threonine modifies a myriad of proteins and regulates their function, stability and localization. O-GlcNAc modification is common among chromosome-associated proteins, such as transcription factors, suggesting its extensive involvement in gene expression regulation. In this study, we demonstrate the O-GlcNAc status of the Sp family members of transcription factors and the functional impact on their transcriptional activities. We highlight the presence of O-GlcNAc residues in Sp3 and Sp4, but not Sp2, as demonstrated by their enrichment in GlcNAc positive protein fractions and by detection of O-GlcNAc residues on Sp3 and Sp4 co-expressed in Escherichia coli together with O-GlcNAc transferase (OGT) using an O-GlcNAc-specific antibody. Deletion mutants of Sp3 and Sp4 indicate that the majority of O-GlcNAc sites reside in their N-terminal transactivation domain. Overall, using reporter gene assays and co-immunoprecipitations, we demonstrate a functional inhibitory role of O-GlcNAc modifications in Sp3 and Sp4 transcription factors. Thereby, our study strengthens the current notion that O-GlcNAc modification is an important regulator of protein interactome." @default.
• W1750204334 created "2016-06-24" @default.
• W1750204334 creator A5074204877 @default.
• W1750204334 creator A5085593215 @default.
• W1750204334 date "2015-11-01" @default.
• W1750204334 modified "2023-09-23" @default.
• W1750204334 title "O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities" @default.
• W1750204334 cites W1539141311 @default.
• W1750204334 cites W1969939865 @default.
• W1750204334 cites W1975678442 @default.
• W1750204334 cites W1979095700 @default.
• W1750204334 cites W1979786837 @default.
• W1750204334 cites W1987282763 @default.
• W1750204334 cites W1996357478 @default.
• W1750204334 cites W1997465116 @default.
• W1750204334 cites W2001642810 @default.
• W1750204334 cites W2005974685 @default.
• W1750204334 cites W2010344297 @default.
• W1750204334 cites W2010499718 @default.
• W1750204334 cites W2017513692 @default.
• W1750204334 cites W2018639404 @default.
• W1750204334 cites W2024218650 @default.
• W1750204334 cites W2024591818 @default.
• W1750204334 cites W2025577759 @default.
• W1750204334 cites W2025748859 @default.
• W1750204334 cites W2031087463 @default.
• W1750204334 cites W2063124267 @default.
• W1750204334 cites W2076469373 @default.
• W1750204334 cites W2077903723 @default.
• W1750204334 cites W2079580613 @default.
• W1750204334 cites W2080053060 @default.
• W1750204334 cites W2082451220 @default.
• W1750204334 cites W2093090845 @default.
• W1750204334 cites W2097711466 @default.
• W1750204334 cites W2098687851 @default.
• W1750204334 cites W2099449144 @default.
• W1750204334 cites W2106169455 @default.
• W1750204334 cites W2107089340 @default.
• W1750204334 cites W2116930183 @default.
• W1750204334 cites W2120036668 @default.
• W1750204334 cites W2129585918 @default.
• W1750204334 cites W2130135884 @default.
• W1750204334 cites W2158953193 @default.
• W1750204334 cites W37487597 @default.
• W1750204334 cites W2048409146 @default.
• W1750204334 doi "https://doi.org/10.1016/j.bbrc.2015.09.155" @default.
• W1750204334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26431879" @default.
• W1750204334 hasPublicationYear "2015" @default.
• W1750204334 type Work @default.
• W1750204334 sameAs 1750204334 @default.
• W1750204334 citedByCount "6" @default.
• W1750204334 countsByYear W17502043342017 @default.
• W1750204334 countsByYear W17502043342018 @default.
• W1750204334 countsByYear W17502043342019 @default.
• W1750204334 countsByYear W17502043342020 @default.
• W1750204334 countsByYear W17502043342021 @default.
• W1750204334 crossrefType "journal-article" @default.
• W1750204334 hasAuthorship W1750204334A5074204877 @default.
• W1750204334 hasAuthorship W1750204334A5085593215 @default.
• W1750204334 hasConcept C104317684 @default.
• W1750204334 hasConcept C11960822 @default.
• W1750204334 hasConcept C1292079 @default.
• W1750204334 hasConcept C138885662 @default.
• W1750204334 hasConcept C143065580 @default.
• W1750204334 hasConcept C179926584 @default.
• W1750204334 hasConcept C185592680 @default.
• W1750204334 hasConcept C27153228 @default.
• W1750204334 hasConcept C2775880066 @default.
• W1750204334 hasConcept C2776414213 @default.
• W1750204334 hasConcept C41895202 @default.
• W1750204334 hasConcept C55493867 @default.
• W1750204334 hasConcept C86339819 @default.
• W1750204334 hasConcept C86803240 @default.
• W1750204334 hasConcept C95444343 @default.
• W1750204334 hasConcept C9760119 @default.
• W1750204334 hasConceptScore W1750204334C104317684 @default.
• W1750204334 hasConceptScore W1750204334C11960822 @default.
• W1750204334 hasConceptScore W1750204334C1292079 @default.
• W1750204334 hasConceptScore W1750204334C138885662 @default.
• W1750204334 hasConceptScore W1750204334C143065580 @default.
• W1750204334 hasConceptScore W1750204334C179926584 @default.
• W1750204334 hasConceptScore W1750204334C185592680 @default.
• W1750204334 hasConceptScore W1750204334C27153228 @default.
• W1750204334 hasConceptScore W1750204334C2775880066 @default.
• W1750204334 hasConceptScore W1750204334C2776414213 @default.
• W1750204334 hasConceptScore W1750204334C41895202 @default.
• W1750204334 hasConceptScore W1750204334C55493867 @default.
• W1750204334 hasConceptScore W1750204334C86339819 @default.
• W1750204334 hasConceptScore W1750204334C86803240 @default.
• W1750204334 hasConceptScore W1750204334C95444343 @default.
• W1750204334 hasConceptScore W1750204334C9760119 @default.
• W1750204334 hasLocation W17502043341 @default.
• W1750204334 hasLocation W17502043342 @default.
• W1750204334 hasOpenAccess W1750204334 @default.
• W1750204334 hasPrimaryLocation W17502043341 @default.
• W1750204334 hasRelatedWork W1646239228 @default.
• W1750204334 hasRelatedWork W1977458426 @default.
• W1750204334 hasRelatedWork W1990353372 @default.
• W1750204334 hasRelatedWork W1992077299 @default.
• W1750204334 hasRelatedWork W1993280894 @default.

• next