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- W1750220554 abstract "Epithelialization of normal wounds occurs by an orderly series of events whereby keratinocytes migrate, proliferate, and differentiate to restore the epidermal barrier function. Keratinocyte migration is one of the earliest and crucial events determining the efficiency of the overall wound repair process. In response to various stimuli including that of growth factors, cytokines and the extracellular matrix, activated keratinocytes at the edges of the wound undergo dramatic morphological changes according to their migratory behaviour through development of protrusive adhesion contacts and cytoskeleton rearrangements. These phenotypic changes are accompanied by the upregulated expression of a new set of genes, among which are adhesion receptors and specific matrix degrading enzymes named matrix metalloproteinases (MMPs). The tightly regulated spatial and temporal MMP expression is crucial for proper re-epithelialization. These multi-domain zinc-containing endopeptidases are necessary for the proper completion of multiple features of epidermal regeneration. They play a key role in the migration process by controlling the repeated cycles of keratinocyte attachment and retraction. In the meantime, they process, degrade or remodel the extracellular matrix often producing cleavages in a gain-of-function manner." @default.
- W1750220554 created "2016-06-24" @default.
- W1750220554 creator A5030342857 @default.
- W1750220554 creator A5057924853 @default.
- W1750220554 date "2015-04-01" @default.
- W1750220554 modified "2023-09-25" @default.
- W1750220554 title "How do epidermal matrix metalloproteinases support re-epithelialization during skin healing?" @default.
- W1750220554 cites W108943637 @default.
- W1750220554 cites W139613233 @default.
- W1750220554 cites W1493072136 @default.
- W1750220554 cites W1949832432 @default.
- W1750220554 cites W1963529390 @default.
- W1750220554 cites W1969830009 @default.
- W1750220554 cites W1970794616 @default.
- W1750220554 cites W1975901799 @default.
- W1750220554 cites W1976068877 @default.
- W1750220554 cites W1982756129 @default.
- W1750220554 cites W1984281928 @default.
- W1750220554 cites W1986353310 @default.
- W1750220554 cites W1987408673 @default.
- W1750220554 cites W1987825791 @default.
- W1750220554 cites W1995767098 @default.
- W1750220554 cites W2001356286 @default.
- W1750220554 cites W2002771508 @default.
- W1750220554 cites W2003500892 @default.
- W1750220554 cites W2003581365 @default.
- W1750220554 cites W2005779622 @default.
- W1750220554 cites W2008550865 @default.
- W1750220554 cites W2010254549 @default.
- W1750220554 cites W2013214195 @default.
- W1750220554 cites W2019720769 @default.
- W1750220554 cites W2021899046 @default.
- W1750220554 cites W2024794839 @default.
- W1750220554 cites W2027150670 @default.
- W1750220554 cites W2027325645 @default.
- W1750220554 cites W2028017296 @default.
- W1750220554 cites W2028147193 @default.
- W1750220554 cites W2030463167 @default.
- W1750220554 cites W2030776545 @default.
- W1750220554 cites W2031809949 @default.
- W1750220554 cites W2032666845 @default.
- W1750220554 cites W2033341544 @default.
- W1750220554 cites W2034752268 @default.
- W1750220554 cites W2036016303 @default.
- W1750220554 cites W2038385625 @default.
- W1750220554 cites W2040234043 @default.
- W1750220554 cites W2042289154 @default.
- W1750220554 cites W2042396998 @default.
- W1750220554 cites W2043622965 @default.
- W1750220554 cites W2047289384 @default.
- W1750220554 cites W2048858410 @default.
- W1750220554 cites W2050039508 @default.
- W1750220554 cites W2050060735 @default.
- W1750220554 cites W2052054447 @default.
- W1750220554 cites W2052096807 @default.
- W1750220554 cites W2053343398 @default.
- W1750220554 cites W2055336782 @default.
- W1750220554 cites W2057679281 @default.
- W1750220554 cites W2059032249 @default.
- W1750220554 cites W2060175990 @default.
- W1750220554 cites W2060745257 @default.
- W1750220554 cites W2063676080 @default.
- W1750220554 cites W2067973973 @default.
- W1750220554 cites W2069837802 @default.
- W1750220554 cites W2071359561 @default.
- W1750220554 cites W2075729495 @default.
- W1750220554 cites W2075965099 @default.
- W1750220554 cites W2081353232 @default.
- W1750220554 cites W2081399863 @default.
- W1750220554 cites W2084458279 @default.
- W1750220554 cites W2087342203 @default.
- W1750220554 cites W2091100304 @default.
- W1750220554 cites W2093279686 @default.
- W1750220554 cites W2093979559 @default.
- W1750220554 cites W2098487159 @default.
- W1750220554 cites W2114068656 @default.
- W1750220554 cites W2115951554 @default.
- W1750220554 cites W2116003761 @default.
- W1750220554 cites W2118379843 @default.
- W1750220554 cites W2121317746 @default.
- W1750220554 cites W2126919832 @default.
- W1750220554 cites W2128049766 @default.
- W1750220554 cites W2138316626 @default.
- W1750220554 cites W2141880708 @default.
- W1750220554 cites W2143816998 @default.
- W1750220554 cites W2151752998 @default.
- W1750220554 cites W2161917366 @default.
- W1750220554 cites W2162982642 @default.
- W1750220554 cites W2173318806 @default.
- W1750220554 cites W2321037169 @default.
- W1750220554 cites W2325727928 @default.
- W1750220554 cites W2358718646 @default.
- W1750220554 doi "https://doi.org/10.1684/ejd.2015.2553" @default.
- W1750220554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26083673" @default.
- W1750220554 hasPublicationYear "2015" @default.
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