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- W1750257363 abstract "Introduction: With easy availability of bedside markers of venous thromboembolism (VTE) like D-dimer, widespread use of these tests often without pre-test probability scoring (PTPS) has become common practice in the diagnostic pathway of VTE. Aims: We set out to assess how effective D-dimer testing is in predicting the likelihood of VTE and whether PTPS adds any further value to D-dimer testing. Method: Consecutive patients with suspected VTE were included for a 3 week period - 90 records were analysed where a D-dimer test (Roche Test kit) was performed as part of the diagnostic pathway in the admissions unit of a teaching hospital providing acute medical services to a population of 450000. Results: Out of the 90 patients: 40 D-dimer tests were positive, 50 negative; 14 with positive tests had radiological confirmation of VTE (CT Pulmonary Angiogram, Ventilation-Perfusion scan or Doppler Ultrasound Scan of the legs), 8 with negative tests still went to have radiological imaging because of high clinical suspicion but all were negative. Thus sensitivity was 100%, specificity 65.79%. Only 31 patients had PTPS; 18 had high or intermediate PTPS with positive D-dimer but only 8 had VTE (44.4%); 1 with low PTPS and positive D-dimer had VTE; 5 with high or intermediate PTPS but negative D-dimer had no VTE. The remaining had low PTPS with no VTE. Conclusions: D-dimer is a very sensitive and reasonably specific tool to aid VTE diagnosis in appropriate clinical presentation, PTPS further aids to rule out the possibility of VTE with a negative D-dimer but does not seem to add any further value in patients with a positive D-dimer, hence PTPS should be included in the interest of patient safety." @default.
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- W1750257363 date "2011-09-01" @default.
- W1750257363 modified "2023-09-25" @default.
- W1750257363 title "D-dimer testing and pre-test probability scoring in the diagnosis of venous thromboembolism" @default.
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