Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750268944> ?p ?o ?g. }
- W1750268944 abstract "As resistance to current therapies remains one of the major hurdles to the successfultreatment of advanced colorectal cancer, we need to understand the mechanisms by whichcancer cells evade therapy-induced cell death. I have investigated whether there is a linkbetween epithelial cell adhesions, and acquired resistance to 5-fluorouracil (5-FU). Icompared three pairs of human colorectal 5-FU-sensitive and -resistant cell lines, andinvestigated whether there was a direct role for E-cadherin and/or the Src family kinase, c-Yes (which is co-amplified with thymidylate synthase) in promoting resistance to 5-FU. Ifound that while knockdown of c-Yes expression had no effect, disruption of E-cadherinusing a blocking antibody caused a reduction in colon cancer cell proliferation and somere-sensitisation to 5-FU. The resistant cells displayed intrinsically higher activities ofputative survival pathways, namely the PI3-kinase/Akt and the MEK/MAP kinasepathways, and these were suppressed when E-cadherin function was blocked.Furthermore, the resistant cells displayed a greater dependence on signalling via the PI3-kinase/Akt pathway for their survival. Finally, preliminary experiments established apossible link between the integrity of E-cadherin-mediated cell-cell junctions, signallingthrough the PI3-kinase/Akt pathway and nuclear localisation of the apoptotic regulatorytumour suppressor protein p53 in modulation of 5-FU-resistance." @default.
- W1750268944 created "2016-06-24" @default.
- W1750268944 creator A5059422518 @default.
- W1750268944 date "2010-09-22" @default.
- W1750268944 modified "2023-09-27" @default.
- W1750268944 title "The role of E-cadherin in colon cancer drug resistance." @default.
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