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• W1750331652 endingPage "3648" @default.
• W1750331652 startingPage "3639" @default.
• W1750331652 abstract "Ca²⁺-activated K⁺ currents and their Ca²⁺ sources through high-threshold voltage-activated Ca²⁺ channels were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons. In the presence of 4-aminopyridine, depolarizing pulses evoked transient outward currents and several components of sustained currents in a subgroup of cells. The fast transient current and a component of the sustained currents were Ca²⁺ dependent and sensitive to charybdotoxin and iberiotoxin but not to apamin, suggesting that they were mediated by large-conductance Ca²⁺-activated K⁺ (BK) channels. Thus, mouse neocortical neurons contain both inactivating and noninactivating populations of BK channels. Blockade of either L-type Ca²⁺ channels by nifedipine or N-type Ca²⁺ channels by ω-conotoxin GVIA reduced the fast transient BK current. These data suggest that the transient BK current is activated by Ca²⁺entry through both N- and L-type Ca²⁺ channels. The physiological role of the fast transient BK current was also examined using current-clamp techniques. Iberiotoxin broadened action potentials (APs), indicating a role of BK current in AP repolarization. Similarly, both the extracellular Ca²⁺ channel blocker Cd²⁺ and the intracellular Ca²⁺chelator BAPTA blocked the transient component of the outward current and broadened APs in a subgroup of cells. Our results indicate that the outward current in pyramidal mouse neurons is composed of multiple components. A fast transient BK current is activated by Ca²⁺ entry through high-threshold voltage-activated Ca²⁺ channels (L- and N-type), and together with other voltage-gated K⁺ currents, this transient BK current plays a role in AP repolarization." @default.
• W1750331652 created "2016-06-24" @default.
• W1750331652 creator A5024707820 @default.
• W1750331652 creator A5040443777 @default.
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• W1750331652 date "2003-05-01" @default.
• W1750331652 modified "2023-10-16" @default.
• W1750331652 title "Calcium Influx via L- and N-Type Calcium Channels Activates a Transient Large-Conductance Ca²⁺-Activated K⁺Current in Mouse Neocortical Pyramidal Neurons" @default.
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• W1750331652 doi "https://doi.org/10.1523/jneurosci.23-09-03639.2003" @default.
• W1750331652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6742183" @default.
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