FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750341556> ?p ?o ?g. }

• W1750341556 endingPage "e0135815" @default.
• W1750341556 startingPage "e0135815" @default.
• W1750341556 abstract "Methacryloxylethyl cetyl ammonium chloride (DMAE-CB) is a polymerizable antibacterial monomer and has been proved as an effective strategy to achieve bioactive bonding with reliable bacterial inhibitory effects. However, the toxicity of DMAE-CB may hamper its wide application in clinical situations. Thus, this study was designed to investigate the toxicity of DMAE-CB and explore the possible protective effects of N-acetyl cysteine (NAC). High performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) analysis showed that chemical binding of NAC and DMAE-CB occurred in a time dependent manner. Pre-incubation of fourty-eight hours is required for adequate reaction between DMAE-CB and NAC. DMAE-CB reduced human dental pulp cells (hDPCs) viability in a dose-dependent manner. The toxic effects of DMAE-CB were accompanied by increased reactive oxygen species (ROS) level and reduced glutathione (GSH) content. NAC alleviated DMAE-CB-induced oxidative stress. Annexin V/ Propidium Iodide (PI) staining and Hoechst 33342 staining indicated that DMAE-CB induced apoptosis. Collapsed mitochondrial membrane potential (MMP) and activation of caspase-3 were also observed after DMAE-CB treatment. NAC rescued hDPCs from DMAE-CB-induced apoptosis, accompanied by lower level of MMP loss and caspase-3 activity. This study assists to elucidate the mechanism underlying the cytotoxic effects of DMAE-CB and provides theoretical supports for the searching of effective strategies to reduce toxicity of quaternary ammonium dental monomers." @default.
• W1750341556 created "2016-06-24" @default.
• W1750341556 creator A5002669249 @default.
• W1750341556 creator A5012677271 @default.
• W1750341556 creator A5015523495 @default.
• W1750341556 creator A5024774280 @default.
• W1750341556 creator A5037916114 @default.
• W1750341556 creator A5041792868 @default.
• W1750341556 creator A5051863134 @default.
• W1750341556 creator A5059955076 @default.
• W1750341556 creator A5075938969 @default.
• W1750341556 creator A5089210156 @default.
• W1750341556 date "2015-08-14" @default.
• W1750341556 modified "2023-10-16" @default.
• W1750341556 title "N-Acetyl Cysteine (NAC)-Directed Detoxification of Methacryloxylethyl Cetyl Ammonium Chloride (DMAE-CB)" @default.
• W1750341556 cites W183556408 @default.
• W1750341556 cites W1972635603 @default.
• W1750341556 cites W1975949258 @default.
• W1750341556 cites W1983153802 @default.
• W1750341556 cites W1989447996 @default.
• W1750341556 cites W1990297258 @default.
• W1750341556 cites W2001119607 @default.
• W1750341556 cites W2001954050 @default.
• W1750341556 cites W2002439304 @default.
• W1750341556 cites W2003805246 @default.
• W1750341556 cites W2004176366 @default.
• W1750341556 cites W2007158142 @default.
• W1750341556 cites W2017391462 @default.
• W1750341556 cites W2033628063 @default.
• W1750341556 cites W2065011148 @default.
• W1750341556 cites W2071421327 @default.
• W1750341556 cites W2074656916 @default.
• W1750341556 cites W2102249133 @default.
• W1750341556 cites W2104053850 @default.
• W1750341556 cites W2104466751 @default.
• W1750341556 cites W2112006259 @default.
• W1750341556 cites W2125117362 @default.
• W1750341556 cites W2141749643 @default.
• W1750341556 cites W2153907040 @default.
• W1750341556 cites W2154734914 @default.
• W1750341556 cites W2159856643 @default.
• W1750341556 cites W2160569622 @default.
• W1750341556 cites W2163181793 @default.
• W1750341556 cites W2170277171 @default.
• W1750341556 doi "https://doi.org/10.1371/journal.pone.0135815" @default.
• W1750341556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4537128" @default.
• W1750341556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26274909" @default.
• W1750341556 hasPublicationYear "2015" @default.
• W1750341556 type Work @default.
• W1750341556 sameAs 1750341556 @default.
• W1750341556 citedByCount "19" @default.
• W1750341556 countsByYear W17503415562016 @default.
• W1750341556 countsByYear W17503415562017 @default.
• W1750341556 countsByYear W17503415562018 @default.
• W1750341556 countsByYear W17503415562019 @default.
• W1750341556 countsByYear W17503415562020 @default.
• W1750341556 countsByYear W17503415562021 @default.
• W1750341556 countsByYear W17503415562022 @default.
• W1750341556 crossrefType "journal-article" @default.
• W1750341556 hasAuthorship W1750341556A5002669249 @default.
• W1750341556 hasAuthorship W1750341556A5012677271 @default.
• W1750341556 hasAuthorship W1750341556A5015523495 @default.
• W1750341556 hasAuthorship W1750341556A5024774280 @default.
• W1750341556 hasAuthorship W1750341556A5037916114 @default.
• W1750341556 hasAuthorship W1750341556A5041792868 @default.
• W1750341556 hasAuthorship W1750341556A5051863134 @default.
• W1750341556 hasAuthorship W1750341556A5059955076 @default.
• W1750341556 hasAuthorship W1750341556A5075938969 @default.
• W1750341556 hasAuthorship W1750341556A5089210156 @default.
• W1750341556 hasBestOaLocation W17503415561 @default.
• W1750341556 hasConcept C116263406 @default.
• W1750341556 hasConcept C13965031 @default.
• W1750341556 hasConcept C178790620 @default.
• W1750341556 hasConcept C181199279 @default.
• W1750341556 hasConcept C185592680 @default.
• W1750341556 hasConcept C190283241 @default.
• W1750341556 hasConcept C2775934118 @default.
• W1750341556 hasConcept C2779201268 @default.
• W1750341556 hasConcept C2779660836 @default.
• W1750341556 hasConcept C2779870022 @default.
• W1750341556 hasConcept C29730261 @default.
• W1750341556 hasConcept C31573885 @default.
• W1750341556 hasConcept C43617362 @default.
• W1750341556 hasConcept C48349386 @default.
• W1750341556 hasConcept C538909803 @default.
• W1750341556 hasConcept C55493867 @default.
• W1750341556 hasConcept C88634738 @default.
• W1750341556 hasConceptScore W1750341556C116263406 @default.
• W1750341556 hasConceptScore W1750341556C13965031 @default.
• W1750341556 hasConceptScore W1750341556C178790620 @default.
• W1750341556 hasConceptScore W1750341556C181199279 @default.
• W1750341556 hasConceptScore W1750341556C185592680 @default.
• W1750341556 hasConceptScore W1750341556C190283241 @default.
• W1750341556 hasConceptScore W1750341556C2775934118 @default.
• W1750341556 hasConceptScore W1750341556C2779201268 @default.
• W1750341556 hasConceptScore W1750341556C2779660836 @default.
• W1750341556 hasConceptScore W1750341556C2779870022 @default.
• W1750341556 hasConceptScore W1750341556C29730261 @default.

• next