Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750356125> ?p ?o ?g. }
- W1750356125 endingPage "215" @default.
- W1750356125 startingPage "209" @default.
- W1750356125 abstract "Al-Bataineh, M. M., van der Merwe, D., Schultz, B. D., Gehring, R. Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV). J. vet. Pharmacol. Therap. 35, 209–215. Mammary epithelial cells express a diversity of membrane transporters including members of organic cation and organic anion (OAT) transporter subfamilies. Four mammal OAT isoforms have been identified: OAT-1, OAT-2, OAT-3, and OAT-4. The pharmacological significance of OAT isoforms has been emphasized because of their role in the movement of a wide variety of substrates across epithelial barriers. The present study identified (molecularly and functionally) bovine OAT isoforms in bovine mammary epithelial (BME-UV) cells. mRNA expression levels of all tested transporters in BME-UV cells were less than expression levels of the corresponding transporters in bovine kidney. Directionality in the flux of P-aminohippuric acid and acetylsalicylate, compounds known to interact with OAT-1 and OAT-2, respectively, across BME-UV monolayers was not observed at the concentrations used in this study. Directionality was, however, observed in the flux of estrone sulfate (EsS). Adding probenecid, penicillin G or nonradiolabeled EsS to the apical donor compartment significantly increased the apical-to-basolateral flux of EsS across the BME-UV monolayer. These results suggest that BME-UV cells express an organic anion transport system, making it a potentially useful model to study the role of this transport system in the mammary epithelial barrier." @default.
- W1750356125 created "2016-06-24" @default.
- W1750356125 creator A5053869533 @default.
- W1750356125 creator A5064837527 @default.
- W1750356125 creator A5076155811 @default.
- W1750356125 creator A5079441199 @default.
- W1750356125 date "2011-05-30" @default.
- W1750356125 modified "2023-10-16" @default.
- W1750356125 title "Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV)" @default.
- W1750356125 cites W1977244805 @default.
- W1750356125 cites W1978207548 @default.
- W1750356125 cites W1985661015 @default.
- W1750356125 cites W1990589891 @default.
- W1750356125 cites W1996402420 @default.
- W1750356125 cites W2002463984 @default.
- W1750356125 cites W2010109864 @default.
- W1750356125 cites W2015026246 @default.
- W1750356125 cites W2020010316 @default.
- W1750356125 cites W2027233606 @default.
- W1750356125 cites W2036409257 @default.
- W1750356125 cites W2036682576 @default.
- W1750356125 cites W2047450440 @default.
- W1750356125 cites W2048192376 @default.
- W1750356125 cites W2048541050 @default.
- W1750356125 cites W2051026643 @default.
- W1750356125 cites W2053145450 @default.
- W1750356125 cites W2067650742 @default.
- W1750356125 cites W2070133422 @default.
- W1750356125 cites W2074813983 @default.
- W1750356125 cites W2075160397 @default.
- W1750356125 cites W2079197876 @default.
- W1750356125 cites W2081750550 @default.
- W1750356125 cites W2085047894 @default.
- W1750356125 cites W2091376558 @default.
- W1750356125 cites W2107277218 @default.
- W1750356125 cites W2110980033 @default.
- W1750356125 cites W2140941706 @default.
- W1750356125 cites W2152732346 @default.
- W1750356125 cites W2161310946 @default.
- W1750356125 cites W2170362099 @default.
- W1750356125 cites W2430000283 @default.
- W1750356125 doi "https://doi.org/10.1111/j.1365-2885.2011.01309.x" @default.
- W1750356125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3165114" @default.
- W1750356125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21623837" @default.
- W1750356125 hasPublicationYear "2011" @default.
- W1750356125 type Work @default.
- W1750356125 sameAs 1750356125 @default.
- W1750356125 citedByCount "3" @default.
- W1750356125 countsByYear W17503561252014 @default.
- W1750356125 countsByYear W17503561252019 @default.
- W1750356125 countsByYear W17503561252021 @default.
- W1750356125 crossrefType "journal-article" @default.
- W1750356125 hasAuthorship W1750356125A5053869533 @default.
- W1750356125 hasAuthorship W1750356125A5064837527 @default.
- W1750356125 hasAuthorship W1750356125A5076155811 @default.
- W1750356125 hasAuthorship W1750356125A5079441199 @default.
- W1750356125 hasBestOaLocation W17503561252 @default.
- W1750356125 hasConcept C104317684 @default.
- W1750356125 hasConcept C123584848 @default.
- W1750356125 hasConcept C149011108 @default.
- W1750356125 hasConcept C153911025 @default.
- W1750356125 hasConcept C185592680 @default.
- W1750356125 hasConcept C2776769776 @default.
- W1750356125 hasConcept C53345823 @default.
- W1750356125 hasConcept C55493867 @default.
- W1750356125 hasConcept C86803240 @default.
- W1750356125 hasConcept C98274493 @default.
- W1750356125 hasConceptScore W1750356125C104317684 @default.
- W1750356125 hasConceptScore W1750356125C123584848 @default.
- W1750356125 hasConceptScore W1750356125C149011108 @default.
- W1750356125 hasConceptScore W1750356125C153911025 @default.
- W1750356125 hasConceptScore W1750356125C185592680 @default.
- W1750356125 hasConceptScore W1750356125C2776769776 @default.
- W1750356125 hasConceptScore W1750356125C53345823 @default.
- W1750356125 hasConceptScore W1750356125C55493867 @default.
- W1750356125 hasConceptScore W1750356125C86803240 @default.
- W1750356125 hasConceptScore W1750356125C98274493 @default.
- W1750356125 hasIssue "3" @default.
- W1750356125 hasLocation W17503561251 @default.
- W1750356125 hasLocation W17503561252 @default.
- W1750356125 hasLocation W17503561253 @default.
- W1750356125 hasLocation W17503561254 @default.
- W1750356125 hasOpenAccess W1750356125 @default.
- W1750356125 hasPrimaryLocation W17503561251 @default.
- W1750356125 hasRelatedWork W1750356125 @default.
- W1750356125 hasRelatedWork W2010145027 @default.
- W1750356125 hasRelatedWork W2027628757 @default.
- W1750356125 hasRelatedWork W2031673133 @default.
- W1750356125 hasRelatedWork W2108997307 @default.
- W1750356125 hasRelatedWork W2417419598 @default.
- W1750356125 hasRelatedWork W3090845647 @default.
- W1750356125 hasRelatedWork W4281559034 @default.
- W1750356125 hasRelatedWork W4377020512 @default.
- W1750356125 hasRelatedWork W58520562 @default.
- W1750356125 hasVolume "35" @default.
- W1750356125 isParatext "false" @default.
- W1750356125 isRetracted "false" @default.
- W1750356125 magId "1750356125" @default.