Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750361788> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W1750361788 abstract "A powerful approach to studying the mechanisms of disease is through the use of transgenic models like Drosophila melanogaster. The Drosophila homologue of the human Down syndrome candidate gene, Dyrk1A, is minibrain (mnb). Studies have shown that mnb can participate in development of the Drosophila eye to control growth and survival through modification of insulin receptor signalling. Huntingtin-interacting protein 1 (Hip1), which differentially interacts with the mutant and normal forms of the Huntington disease protein, huntingtin, has been shown to play a role in Drosophila neurogenesis. There are two naturally occurring versions of the Hip1 protein, a full length version and a truncated version missing the N-terminal ANTH domain, referred to as Hip1ΔANTH. As a biochemical interaction has been identified between Hip1 and Dyrk1A/mnb, this study examines these two genes in Drosophila development. In this study the UAS-Ga14 system was utilized to direct the expression of Dyrk1A/mnb, Hip1 and components of the insulin signalling pathway, akt & foxo1, in the developing dorsal notum and eye. While neither mnb nor foxo1 over-expression has any effect, we found that over-expression of akt, a component of the insulin signalling pathway, increases the microchaetae density on the dorsal notum. The over-expression of mnb and Hip1 in the eye have no effect on eye development. Under the sensitized growth conditions where the GMRGa14 also drives the UASfoxo11 transgene, the full length versions of Hip1 show decreased bristle number and decreased ommatidia number while the truncated versions of Hip1 lacking the lipid-binding ANTH domain show decreased ommatidia number. Over-expression of mnb and Hip1 together with foxo1 show changes in eye development, indicating a possible interaction between these two genes. As these are genes in two completely different diseases, finding how they interact could provide a key insight into finding therapies for neurodegenerative diseases." @default.
- W1750361788 created "2016-06-24" @default.
- W1750361788 creator A5091843955 @default.
- W1750361788 date "2008-01-01" @default.
- W1750361788 modified "2023-09-27" @default.
- W1750361788 title "Ectopic expression of mnb and Hip1 alters Drosophila development" @default.
- W1750361788 hasPublicationYear "2008" @default.
- W1750361788 type Work @default.
- W1750361788 sameAs 1750361788 @default.
- W1750361788 citedByCount "0" @default.
- W1750361788 crossrefType "dissertation" @default.
- W1750361788 hasAuthorship W1750361788A5091843955 @default.
- W1750361788 hasConcept C102230213 @default.
- W1750361788 hasConcept C104317684 @default.
- W1750361788 hasConcept C2780104201 @default.
- W1750361788 hasConcept C54355233 @default.
- W1750361788 hasConcept C86803240 @default.
- W1750361788 hasConcept C95444343 @default.
- W1750361788 hasConcept C97037327 @default.
- W1750361788 hasConceptScore W1750361788C102230213 @default.
- W1750361788 hasConceptScore W1750361788C104317684 @default.
- W1750361788 hasConceptScore W1750361788C2780104201 @default.
- W1750361788 hasConceptScore W1750361788C54355233 @default.
- W1750361788 hasConceptScore W1750361788C86803240 @default.
- W1750361788 hasConceptScore W1750361788C95444343 @default.
- W1750361788 hasConceptScore W1750361788C97037327 @default.
- W1750361788 hasLocation W17503617881 @default.
- W1750361788 hasOpenAccess W1750361788 @default.
- W1750361788 hasPrimaryLocation W17503617881 @default.
- W1750361788 hasRelatedWork W1517686725 @default.
- W1750361788 hasRelatedWork W1846366113 @default.
- W1750361788 hasRelatedWork W1949125222 @default.
- W1750361788 hasRelatedWork W1983044137 @default.
- W1750361788 hasRelatedWork W2023105683 @default.
- W1750361788 hasRelatedWork W2062123572 @default.
- W1750361788 hasRelatedWork W2098076871 @default.
- W1750361788 hasRelatedWork W2128221894 @default.
- W1750361788 hasRelatedWork W2142603809 @default.
- W1750361788 hasRelatedWork W2363071306 @default.
- W1750361788 hasRelatedWork W2415193208 @default.
- W1750361788 hasRelatedWork W2497845126 @default.
- W1750361788 hasRelatedWork W2527755472 @default.
- W1750361788 hasRelatedWork W2570028273 @default.
- W1750361788 hasRelatedWork W2586594268 @default.
- W1750361788 hasRelatedWork W2766156900 @default.
- W1750361788 hasRelatedWork W2792468169 @default.
- W1750361788 hasRelatedWork W2893831799 @default.
- W1750361788 hasRelatedWork W3033118943 @default.
- W1750361788 hasRelatedWork W830788248 @default.
- W1750361788 isParatext "false" @default.
- W1750361788 isRetracted "false" @default.
- W1750361788 magId "1750361788" @default.
- W1750361788 workType "dissertation" @default.