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- W1750366360 endingPage "951" @default.
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- W1750366360 abstract "The understanding of complex molecular mechanisms underlying heart failure (HF) is constantly under revision. Recent research has paid much attention to understanding the growing number of patients that exhibit HF symptoms yet have an ejection fraction similar to a normal phenotype. Termed heart failure with preserved ejection fraction (HFpEF), this novel hypothesis traces its roots to a proinflammatory state initiated in part by the existence of comorbidities that create a favorable environment for the production of reactive oxygen species (ROS). Triggering a cascade that involves reduced nitric oxide (NO) availability, elevated ROS levels in the coronary endothelium eventually contribute to hypertrophy and increased resting tension in cardiomyocytes. Improved understanding of the molecular pathways associated with HFpEF has led to studies that concentrate on reducing ROS production in the heart, boosting NO availability, and increasing exercise capacity for HFpEF patients. This review will explore the latest research into the role of ROS and NO in the progression of HFpEF, as well as discuss the encouraging results of numerous therapeutic studies." @default.
- W1750366360 created "2016-06-24" @default.
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- W1750366360 date "2015-10-15" @default.
- W1750366360 modified "2023-09-27" @default.
- W1750366360 title "Heart failure with preserved ejection fraction: Defining the function of ROS and NO" @default.
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- W1750366360 doi "https://doi.org/10.1152/japplphysiol.01149.2014" @default.
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