FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750369659> ?p ?o ?g. }

• W1750369659 endingPage "777" @default.
• W1750369659 startingPage "771" @default.
• W1750369659 abstract "The effects of insulin and glucagon on liver cell volume and proteolysis were studied in isolated perfused rat liver. The rate of proteolysis was assessed as [3H]leucine release from single-pass-perfused livers from rats which had been prelabelled in vivo by intraperitoneal injection of [3H]leucine. The intracellular water space was determined from the wash-out profiles of simultaneously added [3H]inulin and [14C]urea. In normo-osmotic (305 mosM) control perfusions the intracellular water space was 548 +/- 10 microliters/g wet mass (n = 44) and was increased by 16.5 +/- 2.6% (n = 6), i.e. by 85 +/- 14 microliters/g, after hypoosmotic exposure (225 mosM). Glucagon (0.1 microM) decreased the intracellular water space by 17 +/- 4% (n = 4), whereas insulin (35 nM) increased the intracellular water space by 9.3 +/- 1.4% (n = 15). Also, in isolated rat hepatocyte suspensions insulin (100 nM) caused cell swelling by 10.7 +/- 1.8% (n = 16), which was fully reversed by glucagon. In perfused liver, insulin-induced cell swelling was accompanied by a hepatic net K+ uptake (4.5 +/- 0.2 mumol/g) and an inhibition of proteolysis by 21 +/- 2% (n = 12); further addition of glucagon led to a net K+ release of 3.8 +/- 0.2 mumol/g (n = 7) and fully reversed the insulin effects on both cell volume and proteolysis. Similarly, insulin-induced cell swelling and inhibition of proteolysis were completely antagonized by hyperosmotic (385 mosM) cell shrinkage. Furthermore, cell swelling and inhibition of proteolysis after hypo-osmotic exposure or amino acid addition were reversed by glucagon-induced cell shrinkage. There was a close relationship between the extent of cell swelling and the inhibition of proteolysis, regardless of whether cell volume was modified by insulin, glucagon or aniso-osmotic exposure. The data show that glucagon and insulin are potent modulators of liver cell volume, at least in part by alterations of cellular K+ balance, and that their opposing effects on hepatic proteolysis can largely be explained by opposing effects on cell volume. It is hypothesized that hormone-induced alterations of cell volume may represent an important, not yet recognized, mechanism mediating hormonal effects on metabolism." @default.
• W1750369659 created "2016-06-24" @default.
• W1750369659 creator A5008452332 @default.
• W1750369659 creator A5020374449 @default.
• W1750369659 creator A5035270139 @default.
• W1750369659 creator A5071180693 @default.
• W1750369659 creator A5084208566 @default.
• W1750369659 date "1991-09-15" @default.
• W1750369659 modified "2023-10-04" @default.
• W1750369659 title "Regulation of liver cell volume and proteolysis by glucagon and insulin" @default.
• W1750369659 cites W1027352017 @default.
• W1750369659 cites W1516463671 @default.
• W1750369659 cites W1534812446 @default.
• W1750369659 cites W1604288926 @default.
• W1750369659 cites W1606006161 @default.
• W1750369659 cites W1814062958 @default.
• W1750369659 cites W1894571723 @default.
• W1750369659 cites W1908930362 @default.
• W1750369659 cites W1978259618 @default.
• W1750369659 cites W1983989888 @default.
• W1750369659 cites W1986497066 @default.
• W1750369659 cites W1988998805 @default.
• W1750369659 cites W2013707613 @default.
• W1750369659 cites W2025348942 @default.
• W1750369659 cites W2049983722 @default.
• W1750369659 cites W2074570665 @default.
• W1750369659 cites W2079696649 @default.
• W1750369659 cites W2080695903 @default.
• W1750369659 cites W2086413639 @default.
• W1750369659 cites W2103350570 @default.
• W1750369659 cites W2159217945 @default.
• W1750369659 cites W2160348999 @default.
• W1750369659 cites W2200669062 @default.
• W1750369659 cites W2321167476 @default.
• W1750369659 cites W2330455421 @default.
• W1750369659 cites W9148819 @default.
• W1750369659 doi "https://doi.org/10.1042/bj2780771" @default.
• W1750369659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1151413" @default.
• W1750369659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1898364" @default.
• W1750369659 hasPublicationYear "1991" @default.
• W1750369659 type Work @default.
• W1750369659 sameAs 1750369659 @default.
• W1750369659 citedByCount "77" @default.
• W1750369659 countsByYear W17503696592012 @default.
• W1750369659 countsByYear W17503696592013 @default.
• W1750369659 countsByYear W17503696592014 @default.
• W1750369659 countsByYear W17503696592016 @default.
• W1750369659 countsByYear W17503696592017 @default.
• W1750369659 countsByYear W17503696592020 @default.
• W1750369659 countsByYear W17503696592021 @default.
• W1750369659 crossrefType "journal-article" @default.
• W1750369659 hasAuthorship W1750369659A5008452332 @default.
• W1750369659 hasAuthorship W1750369659A5020374449 @default.
• W1750369659 hasAuthorship W1750369659A5035270139 @default.
• W1750369659 hasAuthorship W1750369659A5071180693 @default.
• W1750369659 hasAuthorship W1750369659A5084208566 @default.
• W1750369659 hasBestOaLocation W17503696592 @default.
• W1750369659 hasConcept C126322002 @default.
• W1750369659 hasConcept C134018914 @default.
• W1750369659 hasConcept C14705128 @default.
• W1750369659 hasConcept C181199279 @default.
• W1750369659 hasConcept C185592680 @default.
• W1750369659 hasConcept C202751555 @default.
• W1750369659 hasConcept C2776200302 @default.
• W1750369659 hasConcept C2778563252 @default.
• W1750369659 hasConcept C2779306644 @default.
• W1750369659 hasConcept C2781307694 @default.
• W1750369659 hasConcept C55493867 @default.
• W1750369659 hasConcept C71924100 @default.
• W1750369659 hasConcept C79879829 @default.
• W1750369659 hasConcept C86803240 @default.
• W1750369659 hasConceptScore W1750369659C126322002 @default.
• W1750369659 hasConceptScore W1750369659C134018914 @default.
• W1750369659 hasConceptScore W1750369659C14705128 @default.
• W1750369659 hasConceptScore W1750369659C181199279 @default.
• W1750369659 hasConceptScore W1750369659C185592680 @default.
• W1750369659 hasConceptScore W1750369659C202751555 @default.
• W1750369659 hasConceptScore W1750369659C2776200302 @default.
• W1750369659 hasConceptScore W1750369659C2778563252 @default.
• W1750369659 hasConceptScore W1750369659C2779306644 @default.
• W1750369659 hasConceptScore W1750369659C2781307694 @default.
• W1750369659 hasConceptScore W1750369659C55493867 @default.
• W1750369659 hasConceptScore W1750369659C71924100 @default.
• W1750369659 hasConceptScore W1750369659C79879829 @default.
• W1750369659 hasConceptScore W1750369659C86803240 @default.
• W1750369659 hasIssue "3" @default.
• W1750369659 hasLocation W17503696591 @default.
• W1750369659 hasLocation W17503696592 @default.
• W1750369659 hasLocation W17503696593 @default.
• W1750369659 hasLocation W17503696594 @default.
• W1750369659 hasOpenAccess W1750369659 @default.
• W1750369659 hasPrimaryLocation W17503696591 @default.
• W1750369659 hasRelatedWork W1967954429 @default.
• W1750369659 hasRelatedWork W1974106130 @default.
• W1750369659 hasRelatedWork W1986101904 @default.
• W1750369659 hasRelatedWork W2026928593 @default.
• W1750369659 hasRelatedWork W2070076315 @default.
• W1750369659 hasRelatedWork W2084131229 @default.

• next