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• W1750377776 abstract "Besides immunoglobulins, there are other molecules that participate in antigen recognition: T-cell antigen receptor (TCR), major histocompatibility complex (MHC) proteins (type I and II), and MHC-related C1 proteins. This chapter focuses on the structures of these molecules. TCR complex is a group of cell membrane proteins responsible for recognition of antigenic peptides localized in the groove of MHC molecules by T cells. MHC proteins—class I and class II—are widespread cell-surface glycoproteins that participate in binding antigen peptides inside the cell and presenting them to the antigen receptors of T cells. The result of the formation of the complex between the TCRs and peptide-MHC is the stimulation of the T cells and activation of the immune response. CD1, a group of antigen-presenting molecules are non polymorphic molecules distantly related to MHC class I proteins. They are composed of the α chain and the β-microglobulin domain. The main antigen-recognizing families of proteins, antibodies, TCRs, and MHC proteins have different functions and accordingly different modes of interaction with antigen. The chapter presents a comparison of antigen-binding by various antigen-recognizing families." @default.
• W1750377776 created "2016-06-24" @default.
• W1750377776 creator A5041968085 @default.
• W1750377776 date "1998-01-01" @default.
• W1750377776 modified "2023-09-27" @default.
• W1750377776 title "Antigen-Recognizing Molecules Other Than Antibodies" @default.
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• W1750377776 doi "https://doi.org/10.1016/b978-012517970-6/50005-9" @default.
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