FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750408366> ?p ?o ?g. }

• W1750408366 endingPage "42" @default.
• W1750408366 startingPage "3837" @default.
• W1750408366 abstract "We evaluated the HMGCoA reductase activity and LDL receptor levels in human colon cancer as well as the effects of simvastatin on in vitro cell growth and apoptosis of DLD-1 and Caco2 cell lines.HMGCoA reductase activity and LDL receptor were measured by radiochemical assay and ELISA method, respectively. Cell growth and apoptosis were evaluated by MTT-test and DNA fragmentation analysis, respectively.Higher HMGCoA reductase activity and LDL receptor levels were detected in cancer than in normal mucosa. An up-regulation of HMGCoA reductase activity was detected in left-sided tumors. Simvastatin treatment produced marked anti-proliferative and pro-aptotic effects in DLD-1. Cell growth inhibition, but no apoptosis, was also evident in Caco2 cells.The cholesterol pathway is involved in colon malignant transformation. Therapeutic strategies using HMGCoA reductase inhibitors as anti-cancer compounds should also take into consideration the biological and clinical differences detected inside colon tracts." @default.
• W1750408366 created "2016-06-24" @default.
• W1750408366 creator A5000374455 @default.
• W1750408366 creator A5009618182 @default.
• W1750408366 creator A5057358362 @default.
• W1750408366 creator A5067807015 @default.
• W1750408366 creator A5072279119 @default.
• W1750408366 creator A5079940936 @default.
• W1750408366 creator A5081146160 @default.
• W1750408366 date "2005-03-02" @default.
• W1750408366 modified "2023-10-08" @default.
• W1750408366 title "Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer." @default.
• W1750408366 cites W2309497012 @default.
• W1750408366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15736419" @default.
• W1750408366 hasPublicationYear "2005" @default.
• W1750408366 type Work @default.
• W1750408366 sameAs 1750408366 @default.
• W1750408366 citedByCount "20" @default.
• W1750408366 countsByYear W17504083662013 @default.
• W1750408366 countsByYear W17504083662014 @default.
• W1750408366 countsByYear W17504083662015 @default.
• W1750408366 countsByYear W17504083662016 @default.
• W1750408366 countsByYear W17504083662018 @default.
• W1750408366 countsByYear W17504083662019 @default.
• W1750408366 crossrefType "journal-article" @default.
• W1750408366 hasAuthorship W1750408366A5000374455 @default.
• W1750408366 hasAuthorship W1750408366A5009618182 @default.
• W1750408366 hasAuthorship W1750408366A5057358362 @default.
• W1750408366 hasAuthorship W1750408366A5067807015 @default.
• W1750408366 hasAuthorship W1750408366A5072279119 @default.
• W1750408366 hasAuthorship W1750408366A5079940936 @default.
• W1750408366 hasAuthorship W1750408366A5081146160 @default.
• W1750408366 hasConcept C104950815 @default.
• W1750408366 hasConcept C121608353 @default.
• W1750408366 hasConcept C126322002 @default.
• W1750408366 hasConcept C134018914 @default.
• W1750408366 hasConcept C134651460 @default.
• W1750408366 hasConcept C170493617 @default.
• W1750408366 hasConcept C181199279 @default.
• W1750408366 hasConcept C190283241 @default.
• W1750408366 hasConcept C2776329913 @default.
• W1750408366 hasConcept C2777320049 @default.
• W1750408366 hasConcept C31573885 @default.
• W1750408366 hasConcept C43759708 @default.
• W1750408366 hasConcept C502942594 @default.
• W1750408366 hasConcept C526805850 @default.
• W1750408366 hasConcept C55493867 @default.
• W1750408366 hasConcept C62112901 @default.
• W1750408366 hasConcept C71924100 @default.
• W1750408366 hasConcept C86803240 @default.
• W1750408366 hasConcept C98274493 @default.
• W1750408366 hasConceptScore W1750408366C104950815 @default.
• W1750408366 hasConceptScore W1750408366C121608353 @default.
• W1750408366 hasConceptScore W1750408366C126322002 @default.
• W1750408366 hasConceptScore W1750408366C134018914 @default.
• W1750408366 hasConceptScore W1750408366C134651460 @default.
• W1750408366 hasConceptScore W1750408366C170493617 @default.
• W1750408366 hasConceptScore W1750408366C181199279 @default.
• W1750408366 hasConceptScore W1750408366C190283241 @default.
• W1750408366 hasConceptScore W1750408366C2776329913 @default.
• W1750408366 hasConceptScore W1750408366C2777320049 @default.
• W1750408366 hasConceptScore W1750408366C31573885 @default.
• W1750408366 hasConceptScore W1750408366C43759708 @default.
• W1750408366 hasConceptScore W1750408366C502942594 @default.
• W1750408366 hasConceptScore W1750408366C526805850 @default.
• W1750408366 hasConceptScore W1750408366C55493867 @default.
• W1750408366 hasConceptScore W1750408366C62112901 @default.
• W1750408366 hasConceptScore W1750408366C71924100 @default.
• W1750408366 hasConceptScore W1750408366C86803240 @default.
• W1750408366 hasConceptScore W1750408366C98274493 @default.
• W1750408366 hasIssue "6" @default.
• W1750408366 hasLocation W17504083661 @default.
• W1750408366 hasOpenAccess W1750408366 @default.
• W1750408366 hasPrimaryLocation W17504083661 @default.
• W1750408366 hasRelatedWork W180349231 @default.
• W1750408366 hasRelatedWork W1943068165 @default.
• W1750408366 hasRelatedWork W1967280935 @default.
• W1750408366 hasRelatedWork W1967588809 @default.
• W1750408366 hasRelatedWork W2005592295 @default.
• W1750408366 hasRelatedWork W2060978652 @default.
• W1750408366 hasRelatedWork W2062022552 @default.
• W1750408366 hasRelatedWork W2071124826 @default.
• W1750408366 hasRelatedWork W2077953915 @default.
• W1750408366 hasRelatedWork W2079430799 @default.
• W1750408366 hasRelatedWork W2094564316 @default.
• W1750408366 hasRelatedWork W2107841008 @default.
• W1750408366 hasRelatedWork W2117046467 @default.
• W1750408366 hasRelatedWork W2126564019 @default.
• W1750408366 hasRelatedWork W2155421604 @default.
• W1750408366 hasRelatedWork W2164980141 @default.
• W1750408366 hasRelatedWork W2318925269 @default.
• W1750408366 hasRelatedWork W2322095705 @default.
• W1750408366 hasRelatedWork W2337040626 @default.
• W1750408366 hasRelatedWork W2185714645 @default.
• W1750408366 hasVolume "24" @default.
• W1750408366 isParatext "false" @default.
• W1750408366 isRetracted "false" @default.
• W1750408366 magId "1750408366" @default.

• next