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- W1750409846 abstract "Competition between bacteria and intrinsic factor (IF) and other B12-binding substances for B12 was examined in vitro. As predicted from the similarity in B12-binding constants between bacteria and IF (Giannella RA, Broitman SA, Zamcheck N: Vitamin B12 uptake by intestinal microorganisms: mechanism and relevance to syndromes of intestinal bacterial overgrowth. J Clin Invest 50:1100-1107, 1971), bacteria can successfully compete with IF for B12. In competition with either hog or human IF, all bacteria studied bound 10 to 27% of available B12 except Proteus mirabilis and Klebsiella pneumoniae which bound 59 and 53% of the B12 respectively. Furthermore, IF and and other B12-binding substances could remove B12 bound to bacteria. When the incubation time between bacteria and B12 prior to the addition of IF was 1 min, IF reclaimed 62 to 73% of the B12 bound to most bacteria but only 3.4 and 10.7% from P. mirabilis and K. pneumoniae, respectively. Only B12 which is bound to the bacterial cell surface (first stage uptake) is available for competition with B12-binding substances; B12 transported inside the bacterial cell (second stage uptake) is no longer available for such competition. Increasing the amount of IF 50-fold did not increase the quantity of B12 removed, while increasing the number of bacteria decreased the quantity of B12 removed. Identical results were obtained when non-IF B12-binding substances were tested. Thus, bacterial interference with vitamin B12 absorption is largely the result of competition between bacterial binding sites and those of IF or non-IF B12-binding substances. However, other factors such as the rate of bacterial transport and/or utilization of B12 and possibly bacterial inactivation of both IF- and non-IF binding substances may weigh the competition in favor of the microorganisms." @default.
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- W1750409846 date "1972-02-01" @default.
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- W1750409846 title "Competition Between Bacteria and Intrinsic Factor for Vitamin B12: Implications for Vitamin B12 Malabsorption in Intestinal Bacterial Overgrowth" @default.
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- W1750409846 doi "https://doi.org/10.1016/s0016-5085(72)80177-x" @default.
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