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- W1750480583 abstract "Multidrug resistance (MDR) refers to a complex phenotype that describes a number of features characterized primarily by resistance to a wide range of structurally unrelated drugs. In this paper we investigated the relationship between drug resistance and resistance to NK-mediated cytotoxicity. Studies with two independently selected multidrug-resistant cell lines indicated that increased drug resistance was associated with both an increased resistance to NK-mediated cytotoxicity and increased levels of membrane P-glycoprotein expression. This resistance to cytotoxicity appears to result partly from an alteration in the membrane structure of the target cells inasmuch as there was a reduction in effector:target cell recognition. Resistance to NK-mediated cytotoxicity should be included with the numerous pleiotropic changes associated with the multidrug resistance phenotype." @default.
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- W1750480583 date "1988-09-01" @default.
- W1750480583 modified "2023-10-18" @default.
- W1750480583 title "Resistance of multidrug‐resistant lines to natural killer‐like cell‐mediated cytotoxicity" @default.
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- W1750480583 doi "https://doi.org/10.1096/fasebj.2.12.3044904" @default.
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