FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750496001> ?p ?o ?g. }

• W1750496001 endingPage "436" @default.
• W1750496001 startingPage "429" @default.
• W1750496001 abstract "Although the pathogenesis of interstitial cystitis/bladder pain syndrome remains unknown, there is a significant correlation of interstitial cystitis/bladder pain syndrome with other chronic pain disorders, such as irritable bowel syndrome, endometriosis and fibromyalgia syndrome. In this review, we highlight evidence supporting neural cross-talk in the dorsal root ganglia, spinal cord and brain levels, which might play a role in the development of chronic pain disorders through central sensitization. In addition, we focus on transient receptor potential V1 and transient receptor potential A1 as the receptor targets for chronic pain conditions, because transient receptor potential V1 and transient receptor potential A1 act as a nocisensor to mediate not only an afferent signal to the dorsal horn of the spinal cord, but also an efferent signal in the periphery through secretion of inflammatory agents, such as substance P and calcitonin gene-related peptide in nociceptive sensory neurons. Furthermore, peripheral inflammation produces multiple inflammatory mediators that act on their cognate receptors to activate intracellular signal transduction pathways and thereby modify the expression and function of transient receptor potential V1 and transient receptor potential A1 (peripheral sensitization). During tissue damage and inflammation, oxidative stress, such as reactive oxygen species or reactive carbonyl species is also generated endogenously. The highly diffusible nature might account for the actions of free radical formation far from the site of injury, thereby producing systemic pain conditions without central sensitization through neural cross-talk. Because oxidative stress is considered to induce activation of transient receptor potential A1, we also discuss exogenous and endogenous oxidative stress to elucidate its role in the pathogenesis of interstitial cystitis/bladder pain syndrome and other chronic pain conditions." @default.
• W1750496001 created "2016-06-24" @default.
• W1750496001 creator A5039271211 @default.
• W1750496001 creator A5041602945 @default.
• W1750496001 creator A5042565610 @default.
• W1750496001 creator A5045164790 @default.
• W1750496001 creator A5073443663 @default.
• W1750496001 date "2012-02-21" @default.
• W1750496001 modified "2023-09-26" @default.
• W1750496001 title "Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: Implication for the pathogenesis of interstitial cystitis/bladder pain syndrome" @default.
• W1750496001 cites W1511198581 @default.
• W1750496001 cites W1693964998 @default.
• W1750496001 cites W1762376464 @default.
• W1750496001 cites W1800213874 @default.
• W1750496001 cites W1883044208 @default.
• W1750496001 cites W191953247 @default.
• W1750496001 cites W1921965616 @default.
• W1750496001 cites W1963857381 @default.
• W1750496001 cites W1966568735 @default.
• W1750496001 cites W1969400739 @default.
• W1750496001 cites W1969446471 @default.
• W1750496001 cites W1970228779 @default.
• W1750496001 cites W1976028390 @default.
• W1750496001 cites W1977124887 @default.
• W1750496001 cites W1981478519 @default.
• W1750496001 cites W1995269583 @default.
• W1750496001 cites W1995705528 @default.
• W1750496001 cites W1996634599 @default.
• W1750496001 cites W1999594063 @default.
• W1750496001 cites W1999917690 @default.
• W1750496001 cites W2000234445 @default.
• W1750496001 cites W2002556755 @default.
• W1750496001 cites W2007852083 @default.
• W1750496001 cites W2008231587 @default.
• W1750496001 cites W2009345293 @default.
• W1750496001 cites W2009967312 @default.
• W1750496001 cites W2012317466 @default.
• W1750496001 cites W2014185236 @default.
• W1750496001 cites W2023550682 @default.
• W1750496001 cites W2024424546 @default.
• W1750496001 cites W2028688696 @default.
• W1750496001 cites W2035257142 @default.
• W1750496001 cites W2040664792 @default.
• W1750496001 cites W2042088510 @default.
• W1750496001 cites W2042125279 @default.
• W1750496001 cites W2042209563 @default.
• W1750496001 cites W2043748249 @default.
• W1750496001 cites W2048050019 @default.
• W1750496001 cites W2050140223 @default.
• W1750496001 cites W2050833893 @default.
• W1750496001 cites W2055999473 @default.
• W1750496001 cites W2056215168 @default.
• W1750496001 cites W2056287855 @default.
• W1750496001 cites W2058736394 @default.
• W1750496001 cites W2061599744 @default.
• W1750496001 cites W2065076024 @default.
• W1750496001 cites W2067385623 @default.
• W1750496001 cites W2070944778 @default.
• W1750496001 cites W2071541376 @default.
• W1750496001 cites W2071819583 @default.
• W1750496001 cites W2073093909 @default.
• W1750496001 cites W2075100277 @default.
• W1750496001 cites W2075137723 @default.
• W1750496001 cites W2076346268 @default.
• W1750496001 cites W2080937909 @default.
• W1750496001 cites W2083910964 @default.
• W1750496001 cites W2089011195 @default.
• W1750496001 cites W2090247886 @default.
• W1750496001 cites W2097247989 @default.
• W1750496001 cites W2098737867 @default.
• W1750496001 cites W2106207830 @default.
• W1750496001 cites W2107063571 @default.
• W1750496001 cites W2109879418 @default.
• W1750496001 cites W2113423163 @default.
• W1750496001 cites W2117953016 @default.
• W1750496001 cites W2118612841 @default.
• W1750496001 cites W2120229762 @default.
• W1750496001 cites W2125272584 @default.
• W1750496001 cites W2129326126 @default.
• W1750496001 cites W2131166849 @default.
• W1750496001 cites W2132676412 @default.
• W1750496001 cites W2132926305 @default.
• W1750496001 cites W2134724878 @default.
• W1750496001 cites W2137445147 @default.
• W1750496001 cites W2139416059 @default.
• W1750496001 cites W2145414080 @default.
• W1750496001 cites W2152714220 @default.
• W1750496001 cites W2155935601 @default.
• W1750496001 cites W2156733405 @default.
• W1750496001 cites W2160611045 @default.
• W1750496001 cites W2164676774 @default.
• W1750496001 cites W2165375223 @default.
• W1750496001 cites W2165499151 @default.
• W1750496001 cites W2165979101 @default.
• W1750496001 cites W2170387852 @default.
• W1750496001 cites W2171827987 @default.
• W1750496001 cites W2321128198 @default.
• W1750496001 cites W2949582036 @default.

• next