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• W175056559 abstract "In patients coinfected and treated for both HIV-1 and hepatitis C virus (HCV), administration of ribavirin (RBV) may result in altered intracellular drug levels of nucleoside reverse transcriptase inhibitors through inhibition of inosine 5′-monophosphate dehydrogenase. Drug interactions between tenofovir and RBV were studied in vitro in order to provide insights into the safety of co-administration of tenofovir disoproxil fumarate (DF) and RBV in HCV/HIV-1-coinfected patients. In accordance with previous in vitro studies, strongly increased anti-HIV activity was observed when RBV was combined with didanosine (ddI). In contrast, low-level anti-HIV antagonism was observed when RBV was combined with either tenofovir or abacavir. Significantly stronger anti-HIV antagonism was observed when RBV was combined with either zidovudine, stavudine, emtricitabine or lamivudine. Thus, although tenofovir and ddI are both adenosine analogues, their in vitro interactions with RBV are markedly different. These results suggest a low potential for increased toxicity upon co-administration of teno-fovir DF with RBV in patients." @default.
• W175056559 created "2016-06-24" @default.
• W175056559 creator A5008851778 @default.
• W175056559 creator A5051466983 @default.
• W175056559 date "2005-02-01" @default.
• W175056559 modified "2023-10-17" @default.
• W175056559 title "<i>In Vitro</i>Combination Studies of Tenofovir and Other Nucleoside Analogues with Ribavirin against HIV-1" @default.
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• W175056559 doi "https://doi.org/10.1177/135965350501000217" @default.
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