FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750631750> ?p ?o ?g. }

• W1750631750 endingPage "554" @default.
• W1750631750 startingPage "547" @default.
• W1750631750 abstract "GADD153 is a CCAAT/enhancer-binding-protein-related gene that may function to control cellular growth in response to stress signals. In this study, a variety of oxidant treatments were shown to stimulate endogenous GADD153 mRNA expression and to transcriptionally activate a GADD153 promoter-reporter gene construct in transfected HeLa cells. Both commonalities and distinctions in the induction of GADD153 by H2O2 and the thiol-reactive compound arsenite were demonstrated. GADD153 mRNA induction by both H2O2 and arsenite was potentiated by GSH depletion, and completely inhibited by N-acetyl-cysteine. o-Phenanthroline and mannitol blocked GADD153 induction by H2O2, indicating that iron-generated hydroxyl radical mediates this induction. Concordantly, GSH peroxidase overexpression in WI38 cells attenuated GADD153 mRNA induction by H2O2. However, GADD153 induction by arsenite was only modestly reduced in the same cells, suggesting a lesser contribution of peroxides to gene activation by arsenite. We also demonstrated that oxidative stress participates in the induction of GADD153 by UVC (254 nm) irradiation. Finally, both promoter-deletion analysis and point mutation of the AP-1 site in an otherwise intact promoter support a significant role for AP-1 in transcriptional activation of GADD153 by UVC or oxidant treatment. Indeed, exposure of cells to oxidants or UVC stimulated binding of Fos and Jun to the GADD153 AP-1 element. Together, these results demonstrate that both free-radical generation and thiol modification can transcriptionally activate GADD153, and that AP-1 is critical to oxidative regulation of this gene. This study further supports a role for the GADD153 gene product in the cellular response to oxidant injury." @default.
• W1750631750 created "2016-06-24" @default.
• W1750631750 creator A5022101190 @default.
• W1750631750 creator A5050400980 @default.
• W1750631750 creator A5054226597 @default.
• W1750631750 date "1996-03-01" @default.
• W1750631750 modified "2023-10-16" @default.
• W1750631750 title "Induction of the mammalian stress response gene <i>GADD153</i> by oxidative stress: role of AP-1 element" @default.
• W1750631750 cites W1480352152 @default.
• W1750631750 cites W1481866568 @default.
• W1750631750 cites W1483926031 @default.
• W1750631750 cites W1489669524 @default.
• W1750631750 cites W1535457969 @default.
• W1750631750 cites W1540141309 @default.
• W1750631750 cites W1550007121 @default.
• W1750631750 cites W1577403013 @default.
• W1750631750 cites W1578330187 @default.
• W1750631750 cites W1580210576 @default.
• W1750631750 cites W1593417211 @default.
• W1750631750 cites W1603378617 @default.
• W1750631750 cites W1831056283 @default.
• W1750631750 cites W1861749169 @default.
• W1750631750 cites W1968621561 @default.
• W1750631750 cites W1971334092 @default.
• W1750631750 cites W1981165639 @default.
• W1750631750 cites W2003962192 @default.
• W1750631750 cites W2032038465 @default.
• W1750631750 cites W2045965817 @default.
• W1750631750 cites W2045975035 @default.
• W1750631750 cites W2049296174 @default.
• W1750631750 cites W2058161381 @default.
• W1750631750 cites W2062725855 @default.
• W1750631750 cites W2064280448 @default.
• W1750631750 cites W2083468617 @default.
• W1750631750 cites W2087284330 @default.
• W1750631750 cites W2092449641 @default.
• W1750631750 cites W2099973867 @default.
• W1750631750 cites W2115583464 @default.
• W1750631750 cites W2144206181 @default.
• W1750631750 cites W2149870206 @default.
• W1750631750 cites W2164322102 @default.
• W1750631750 cites W2315512556 @default.
• W1750631750 cites W2418964759 @default.
• W1750631750 cites W2576734941 @default.
• W1750631750 doi "https://doi.org/10.1042/bj3140547" @default.
• W1750631750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1217084" @default.
• W1750631750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8670069" @default.
• W1750631750 hasPublicationYear "1996" @default.
• W1750631750 type Work @default.
• W1750631750 sameAs 1750631750 @default.
• W1750631750 citedByCount "193" @default.
• W1750631750 countsByYear W17506317502012 @default.
• W1750631750 countsByYear W17506317502013 @default.
• W1750631750 countsByYear W17506317502014 @default.
• W1750631750 countsByYear W17506317502015 @default.
• W1750631750 countsByYear W17506317502016 @default.
• W1750631750 countsByYear W17506317502017 @default.
• W1750631750 countsByYear W17506317502018 @default.
• W1750631750 countsByYear W17506317502019 @default.
• W1750631750 countsByYear W17506317502020 @default.
• W1750631750 countsByYear W17506317502021 @default.
• W1750631750 crossrefType "journal-article" @default.
• W1750631750 hasAuthorship W1750631750A5022101190 @default.
• W1750631750 hasAuthorship W1750631750A5050400980 @default.
• W1750631750 hasAuthorship W1750631750A5054226597 @default.
• W1750631750 hasBestOaLocation W17506317502 @default.
• W1750631750 hasConcept C104317684 @default.
• W1750631750 hasConcept C150194340 @default.
• W1750631750 hasConcept C153911025 @default.
• W1750631750 hasConcept C165864922 @default.
• W1750631750 hasConcept C178790620 @default.
• W1750631750 hasConcept C185592680 @default.
• W1750631750 hasConcept C2776151105 @default.
• W1750631750 hasConcept C2776305511 @default.
• W1750631750 hasConcept C502230775 @default.
• W1750631750 hasConcept C55493867 @default.
• W1750631750 hasConcept C86803240 @default.
• W1750631750 hasConcept C95444343 @default.
• W1750631750 hasConceptScore W1750631750C104317684 @default.
• W1750631750 hasConceptScore W1750631750C150194340 @default.
• W1750631750 hasConceptScore W1750631750C153911025 @default.
• W1750631750 hasConceptScore W1750631750C165864922 @default.
• W1750631750 hasConceptScore W1750631750C178790620 @default.
• W1750631750 hasConceptScore W1750631750C185592680 @default.
• W1750631750 hasConceptScore W1750631750C2776151105 @default.
• W1750631750 hasConceptScore W1750631750C2776305511 @default.
• W1750631750 hasConceptScore W1750631750C502230775 @default.
• W1750631750 hasConceptScore W1750631750C55493867 @default.
• W1750631750 hasConceptScore W1750631750C86803240 @default.
• W1750631750 hasConceptScore W1750631750C95444343 @default.
• W1750631750 hasIssue "2" @default.
• W1750631750 hasLocation W17506317501 @default.
• W1750631750 hasLocation W17506317502 @default.
• W1750631750 hasLocation W17506317503 @default.
• W1750631750 hasLocation W17506317504 @default.
• W1750631750 hasOpenAccess W1750631750 @default.
• W1750631750 hasPrimaryLocation W17506317501 @default.
• W1750631750 hasRelatedWork W1581778452 @default.

• next