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- W1750653145 abstract "Mammalian TFIIIB can be separated into two fractions required for transcription of the adenovirus type 2 VAI gene, which have been designated 0.38M-TFIIIB and 0.48M-TFIIIB. While 0.48M-TFIIIB has not been characterized, 0.38M-TFIIIB corresponds to a TBP-containing complex. We describe here the purification of this complex, which consists of TBP and a closely associated polypeptide of 88 kDa, and the isolation of a cDNA corresponding to the 88-kDa polypeptide. The predicted protein sequence reveals that the 88-kDa polypeptide corresponds to a human homolog of the Saccharomyces cerevisiae BRF protein, a subunit of yeast TFIIIB. Human BRF (hBRF) probably corresponds to TFIIIB90, a protein previously cloned by Wang and Roeder (Proc. Natl. Acad. Sci. USA 92:7026-7030, 1995), although its predicted amino acid sequence differs from that reported for TFIIIB90 over a stretch of 67 amino acids as a result of frameshifts. Immunodepletion of more than 90 to 95% of the hBRF present in a transcription extract severely debilitates transcription from the tRNA-type VAI promoter but does not affect transcription from the TATA box-containing human U6 promoter, suggesting that the 0.38M-TFIIIB complex, and perhaps hBRF as well, is not required for U6 transcription." @default.
- W1750653145 created "2016-06-24" @default.
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- W1750653145 date "1996-12-01" @default.
- W1750653145 modified "2023-10-16" @default.
- W1750653145 title "RNA Polymerase III Transcription from the Human U6 and Adenovirus Type 2 VAI Promoters Has Different Requirements for Human BRF, a Subunit of Human TFIIIB" @default.
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- W1750653145 doi "https://doi.org/10.1128/mcb.16.12.7031" @default.
- W1750653145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/231706" @default.
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