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- W1750656282 endingPage "e1005059" @default.
- W1750656282 startingPage "e1005059" @default.
- W1750656282 abstract "Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is involved in the regulation of transcription, gene expression, chromatin structure, nuclear transport and RNA metabolism. Sumoylation is also linked, both positively and negatively, with the replication of many different viruses both in terms of modification of viral proteins and modulation of sumoylated cellular proteins that influence the efficiency of infection. One prominent example of the latter is the widespread reduction in the levels of cellular sumoylated species induced by herpes simplex virus type 1 (HSV-1) ubiquitin ligase ICP0. This activity correlates with relief from intrinsic immunity antiviral defence mechanisms. Previous work has shown that ICP0 is selective in substrate choice, with some sumoylated proteins such the promyelocytic leukemia protein PML being extremely sensitive, while RanGAP is completely resistant. Here we present a comprehensive proteomic analysis of changes in the cellular SUMO2 proteome during HSV-1 infection. Amongst the 877 potentially sumoylated species detected, we identified 124 whose abundance was decreased by a factor of 3 or more by the virus, several of which were validated by western blot and expression analysis. We found many previously undescribed substrates of ICP0 whose degradation occurs by a range of mechanisms, influenced or not by sumoylation and/or the SUMO2 interaction motif within ICP0. Many of these proteins are known or are predicted to be involved in the regulation of transcription, chromatin assembly or modification. These results present novel insights into mechanisms and host cell proteins that might influence the efficiency of HSV-1 infection." @default.
- W1750656282 created "2016-06-24" @default.
- W1750656282 creator A5005595025 @default.
- W1750656282 creator A5028497063 @default.
- W1750656282 creator A5030297260 @default.
- W1750656282 creator A5071849213 @default.
- W1750656282 creator A5087117480 @default.
- W1750656282 creator A5091594365 @default.
- W1750656282 creator A5089272069 @default.
- W1750656282 date "2015-07-22" @default.
- W1750656282 modified "2023-09-25" @default.
- W1750656282 title "Analysis of the SUMO2 Proteome during HSV-1 Infection" @default.
- W1750656282 cites W106961331 @default.
- W1750656282 cites W1515061907 @default.
- W1750656282 cites W1516008369 @default.
- W1750656282 cites W1541812013 @default.
- W1750656282 cites W1555606047 @default.
- W1750656282 cites W1628209714 @default.
- W1750656282 cites W1744223828 @default.
- W1750656282 cites W1822042631 @default.
- W1750656282 cites W1964242863 @default.
- W1750656282 cites W1968697793 @default.
- W1750656282 cites W1970993743 @default.
- W1750656282 cites W1972245437 @default.
- W1750656282 cites W1976732528 @default.
- W1750656282 cites W1977088690 @default.
- W1750656282 cites W1990799165 @default.
- W1750656282 cites W1991180357 @default.
- W1750656282 cites W1991366673 @default.
- W1750656282 cites W1993431561 @default.
- W1750656282 cites W1998291766 @default.
- W1750656282 cites W1998859037 @default.
- W1750656282 cites W2002439601 @default.
- W1750656282 cites W2003019920 @default.
- W1750656282 cites W2007592260 @default.
- W1750656282 cites W2008221108 @default.
- W1750656282 cites W2008726529 @default.
- W1750656282 cites W2012802011 @default.
- W1750656282 cites W2018075615 @default.
- W1750656282 cites W2023170691 @default.
- W1750656282 cites W2023858601 @default.
- W1750656282 cites W2025209619 @default.
- W1750656282 cites W2025753061 @default.
- W1750656282 cites W2027085235 @default.
- W1750656282 cites W2032437024 @default.
- W1750656282 cites W2034116174 @default.
- W1750656282 cites W2036321220 @default.
- W1750656282 cites W2038720022 @default.
- W1750656282 cites W2039741753 @default.
- W1750656282 cites W2043927273 @default.
- W1750656282 cites W2044499746 @default.
- W1750656282 cites W2046244922 @default.
- W1750656282 cites W2051166632 @default.
- W1750656282 cites W2054544535 @default.
- W1750656282 cites W2054806801 @default.
- W1750656282 cites W2055041452 @default.
- W1750656282 cites W2057294377 @default.
- W1750656282 cites W2058434102 @default.
- W1750656282 cites W2059823369 @default.
- W1750656282 cites W2076334533 @default.
- W1750656282 cites W2076984362 @default.
- W1750656282 cites W2080752012 @default.
- W1750656282 cites W2084650850 @default.
- W1750656282 cites W2093877605 @default.
- W1750656282 cites W2095012384 @default.
- W1750656282 cites W2096372976 @default.
- W1750656282 cites W2096546138 @default.
- W1750656282 cites W2102247014 @default.
- W1750656282 cites W2103811795 @default.
- W1750656282 cites W2104677263 @default.
- W1750656282 cites W2106335654 @default.
- W1750656282 cites W2107749421 @default.
- W1750656282 cites W2111133561 @default.
- W1750656282 cites W2113117857 @default.
- W1750656282 cites W2113504375 @default.
- W1750656282 cites W2115147255 @default.
- W1750656282 cites W2115211177 @default.
- W1750656282 cites W2119609500 @default.
- W1750656282 cites W2123829154 @default.
- W1750656282 cites W2127707170 @default.
- W1750656282 cites W2129568627 @default.
- W1750656282 cites W2131517280 @default.
- W1750656282 cites W2132093817 @default.
- W1750656282 cites W2135372082 @default.
- W1750656282 cites W2136220836 @default.
- W1750656282 cites W2136752130 @default.
- W1750656282 cites W2137638498 @default.
- W1750656282 cites W2142756909 @default.
- W1750656282 cites W2143631363 @default.
- W1750656282 cites W2143883087 @default.
- W1750656282 cites W2146315095 @default.
- W1750656282 cites W2147231609 @default.
- W1750656282 cites W2148591914 @default.
- W1750656282 cites W2149065115 @default.
- W1750656282 cites W2149299119 @default.
- W1750656282 cites W2152135949 @default.
- W1750656282 cites W2152145111 @default.
- W1750656282 cites W2152497434 @default.