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- W175069889 abstract "Fungal infections of crops and humans are widespread, and the costs associated with their prevention and treatment highlight a need for new antifungal agents. In addition, increased antimicrobial resistance enhances the need for new classes of antibiotics. Fortunately, fungi themselves are a rich source of bioactive secondary metabolites, including some clinically useful antifungal agents. The role of fungi as decomposers sometimes results in these organisms being parasitic, mutualistic, or commensal with other organisms in their ecological communities. Such interspecies relationships are commonly associated with the production of biologically active compounds. The research described in this thesis involves studies of fungi from different ecological niches as part of an ongoing search for new bioactive natural products. Chapters 2–4 in this thesis describe investigations of secondary metabolites produced by selected fungal endophytes of corn. Endophytic fungi are those that grow in association with a plant host. Our group has previously reported the occurrence of antifungal pyrrocidines and phytotoxic dihydroresorcylide analogues from the maize–protective endophyte Acremonium zeae. The further studies discussed in this thesis describe bioactive secondary metabolites produced by isolates of three other endophytic fungal species. While" @default.
- W175069889 created "2016-06-24" @default.
- W175069889 creator A5075007582 @default.
- W175069889 date "2018-11-29" @default.
- W175069889 modified "2023-10-11" @default.
- W175069889 title "Chemical investigations of endophytitc and fungicolous fungi" @default.
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- W175069889 doi "https://doi.org/10.17077/etd.222k1kqk" @default.
- W175069889 hasPublicationYear "2018" @default.
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