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- W1750702143 abstract "Triptolide, a biologically active natural product from Tripterygium wilfordii, protects neurons from inflammation-mediated damage. Our results showed for the first time that triptolide inhibited the expression of CXCR2 and presenilin in a neuroblastoma cell line SHSY5Ysw. Moreover, triptolide poten tly inhibited amyloid-β1-42 production with IC50 value of 30 pM in HEK293sw cells or 2 nM in SHSY5Ysw cells, respectively. We also demonstrated that triptolide prevented primary cortical neurons from chemokine CXCL1-induced cytotoxicity. Therefore, our study indicates that the neural protective effect of triptolide is largely mediated by inhibiting CXCR2 activity." @default.
- W1750702143 created "2016-06-24" @default.
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- W1750702143 date "2012-12-03" @default.
- W1750702143 modified "2023-10-16" @default.
- W1750702143 title "Triptolide Inhibits Amyloid-β Production and Protects Neural Cells by Inhibiting CXCR2 Activity" @default.
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- W1750702143 doi "https://doi.org/10.3233/jad-2012-120841" @default.
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