FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1750841067> ?p ?o ?g. }

• W1750841067 endingPage "990" @default.
• W1750841067 startingPage "976" @default.
• W1750841067 abstract "Abstract Capsular polysaccharides of encapsulated bacteria do not induce immune response in newborns and the mechanism for this unresponsiveness is not clear. In adults, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) is a TNFR family member molecule with a pivotal role in Ab responses against polysaccharide vaccines. We investigated the expression and the functions of the TNF family cytokines, B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), and their receptors in newborn mice and found that TACI expression on B lymphocytes was dramatically reduced (p &lt; 0.0001) in newborns as compared with adults. More importantly, TACI ligands BAFF or APRIL were unable to induce IgA/IgG/IgM secretion from newborn B lymphocytes. Additionally, TACI expression seems to be important in plasma cell development. Indeed, in contrast to adults, stimulation of newborn B lymphocytes with BAFF or APRIL did not result in up-regulation of CD138 expression. In vitro or in vivo exposure of newborn B lymphocytes to oligodeoxynucleotides (CpG ODN) led to up-regulation of TACI expression on newly formed, follicular, and marginal zone as well as B1 B lymphocyte populations, and rendered them responsive to BAFF- or APRIL-mediated CD138 expression and IgA/IgG secretion. Finally, immunization of newborn BALB/c mice but not TACI knockout mice with CpG ODN containing (4-hydroxy-3-nitrophenyl)acetyl-Ficoll led to development of IgG Abs against (4-hydroxy-3-nitrophenyl)acetyl. These findings demonstrate that low TACI expression may be a critical factor that determines the susceptibility of newborns to infections with encapsulated bacteria and the impaired immunogenicity of polysaccharide vaccines. Finally, CpG ODNs may correct deficient newborn response to polysaccharide vaccines by up-regulating TACI." @default.
• W1750841067 created "2016-06-24" @default.
• W1750841067 creator A5010467269 @default.
• W1750841067 creator A5034801475 @default.
• W1750841067 creator A5039788757 @default.
• W1750841067 creator A5047744808 @default.
• W1750841067 creator A5072935232 @default.
• W1750841067 date "2008-07-15" @default.
• W1750841067 modified "2023-10-16" @default.
• W1750841067 title "Deficient TACI Expression on B Lymphocytes of Newborn Mice Leads to Defective Ig Secretion in Response to BAFF or APRIL" @default.
• W1750841067 cites W1482234266 @default.
• W1750841067 cites W1492447786 @default.
• W1750841067 cites W1505026047 @default.
• W1750841067 cites W1523846987 @default.
• W1750841067 cites W1561493617 @default.
• W1750841067 cites W1566027841 @default.
• W1750841067 cites W1647966696 @default.
• W1750841067 cites W1678848363 @default.
• W1750841067 cites W1935116877 @default.
• W1750841067 cites W1946302728 @default.
• W1750841067 cites W1975249184 @default.
• W1750841067 cites W1983972858 @default.
• W1750841067 cites W1984435906 @default.
• W1750841067 cites W1984531586 @default.
• W1750841067 cites W1984605559 @default.
• W1750841067 cites W1988422289 @default.
• W1750841067 cites W1993573963 @default.
• W1750841067 cites W2005599815 @default.
• W1750841067 cites W2005673287 @default.
• W1750841067 cites W2016304443 @default.
• W1750841067 cites W2016777949 @default.
• W1750841067 cites W2025436792 @default.
• W1750841067 cites W2025680630 @default.
• W1750841067 cites W2028764793 @default.
• W1750841067 cites W2030799973 @default.
• W1750841067 cites W2034259068 @default.
• W1750841067 cites W2034779840 @default.
• W1750841067 cites W2035189752 @default.
• W1750841067 cites W2038264470 @default.
• W1750841067 cites W2045594979 @default.
• W1750841067 cites W2058074942 @default.
• W1750841067 cites W2059383814 @default.
• W1750841067 cites W2070670205 @default.
• W1750841067 cites W2072417345 @default.
• W1750841067 cites W2075870096 @default.
• W1750841067 cites W2083089709 @default.
• W1750841067 cites W2086275027 @default.
• W1750841067 cites W2092567494 @default.
• W1750841067 cites W2100776844 @default.
• W1750841067 cites W2108244474 @default.
• W1750841067 cites W2113335928 @default.
• W1750841067 cites W2116724928 @default.
• W1750841067 cites W2119170361 @default.
• W1750841067 cites W2128420632 @default.
• W1750841067 cites W2130579013 @default.
• W1750841067 cites W2134964066 @default.
• W1750841067 cites W2135668656 @default.
• W1750841067 cites W2136590857 @default.
• W1750841067 cites W2139657682 @default.
• W1750841067 cites W2145345130 @default.
• W1750841067 cites W2146948404 @default.
• W1750841067 cites W2149186863 @default.
• W1750841067 cites W2150721047 @default.
• W1750841067 cites W2159864982 @default.
• W1750841067 cites W2159917672 @default.
• W1750841067 cites W2161291046 @default.
• W1750841067 cites W2162452586 @default.
• W1750841067 cites W2163150086 @default.
• W1750841067 cites W2163673566 @default.
• W1750841067 cites W2166345488 @default.
• W1750841067 cites W4254710724 @default.
• W1750841067 doi "https://doi.org/10.4049/jimmunol.181.2.976" @default.
• W1750841067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18606649" @default.
• W1750841067 hasPublicationYear "2008" @default.
• W1750841067 type Work @default.
• W1750841067 sameAs 1750841067 @default.
• W1750841067 citedByCount "70" @default.
• W1750841067 countsByYear W17508410672012 @default.
• W1750841067 countsByYear W17508410672013 @default.
• W1750841067 countsByYear W17508410672014 @default.
• W1750841067 countsByYear W17508410672015 @default.
• W1750841067 countsByYear W17508410672016 @default.
• W1750841067 countsByYear W17508410672017 @default.
• W1750841067 countsByYear W17508410672018 @default.
• W1750841067 countsByYear W17508410672019 @default.
• W1750841067 countsByYear W17508410672020 @default.
• W1750841067 countsByYear W17508410672021 @default.
• W1750841067 countsByYear W17508410672022 @default.
• W1750841067 crossrefType "journal-article" @default.
• W1750841067 hasAuthorship W1750841067A5010467269 @default.
• W1750841067 hasAuthorship W1750841067A5034801475 @default.
• W1750841067 hasAuthorship W1750841067A5039788757 @default.
• W1750841067 hasAuthorship W1750841067A5047744808 @default.
• W1750841067 hasAuthorship W1750841067A5072935232 @default.
• W1750841067 hasConcept C134018914 @default.
• W1750841067 hasConcept C159654299 @default.
• W1750841067 hasConcept C170286685 @default.
• W1750841067 hasConcept C170493617 @default.

• next