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- W1750971461 endingPage "57" @default.
- W1750971461 startingPage "27" @default.
- W1750971461 abstract "Publisher Summary The antiphagocytic effect is mediated by a Yersinia virulence protein, the protein tyrosine phosphatase (PTPase) YopH, which is delivered from an extracellularly located bacterium into the interacting host cell. Once inside, the PTPase subverts the host-cell signaling that is important for the phagocytic process. The molecular mechanism of this PTPase within the host cell includes specific targeting to focal complex like structures and the subsequent dephosphorylation of certain proteins that are believed to constitute critical components of these structures. This chapter is focused on the mechanisms underlying Yersinia pathogenicity, in particular the molecular mechanism behind the antiphagocytic effect of YopH and on the role of the YopH targets, focal adhesion kinase, p130Cas, and focal complexes as such in the phagocytic process. The prevention of phagocytic uptake by professional phagocytes, a process termed antiphagocytosis, is an important virulence mechanism of Yersinia spp. This property greatly contributes to the extracellular life style of these pathogens by allowing them to accumulate and proliferate in lymphatic tissue, which abounds in immune cells." @default.
- W1750971461 created "2016-06-24" @default.
- W1750971461 creator A5010587717 @default.
- W1750971461 creator A5027872525 @default.
- W1750971461 creator A5063695980 @default.
- W1750971461 date "1999-01-01" @default.
- W1750971461 modified "2023-09-26" @default.
- W1750971461 title "Antiphagocytosis by Yersinia" @default.
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