Matches in SemOpenAlex for { <https://semopenalex.org/work/W1751012597> ?p ?o ?g. }
- W1751012597 abstract "Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in Jurkat T lymphoma cells. One of the characteristics of the phase preceding overt apoptosis is the marked downregulation of protein synthesis. We have investigated factors that can influence this response and have explored some of the signaling pathways involved. We show that interferon-α (IFNα) pretreatment desensitizes Jurkat cells to TRAIL-induced inhibition of protein synthesis, such that the concentration of TRAIL required for 50% inhibition is increased by 10-fold. The inhibition of translation is characterized by dephosphorylation of the eIF4E-binding protein 4E-BP1 and IFNα desensitizes Jurkat cells to this effect. IFNα also inhibits TRAIL-mediated dephosphorylation of the growth-promoting protein kinase B (Akt). Since Jurkat cells are defective for phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and therefore have constitutive phosphoinositide 3-kinase (PI3K) activity, we investigated the consequences for protein synthesis of inhibiting PI3K using LY294002. Inhibition of PI3K partially inhibits translation, but also enhances the effect of a suboptimal concentration of TRAIL. However, LY294002 does not block the ability of IFNα to protect protein synthesis from TRAIL-induced inhibition. Data are presented suggesting that IFNα impairs the process of activation of caspase-8 within the TRAIL death-inducing signaling complex." @default.
- W1751012597 created "2016-06-24" @default.
- W1751012597 creator A5029919366 @default.
- W1751012597 creator A5034035769 @default.
- W1751012597 creator A5057395376 @default.
- W1751012597 creator A5065520980 @default.
- W1751012597 date "2014-10-01" @default.
- W1751012597 modified "2023-09-27" @default.
- W1751012597 title "Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor α-Related Apoptosis-Inducing Ligand" @default.
- W1751012597 cites W117213651 @default.
- W1751012597 cites W1900402474 @default.
- W1751012597 cites W1903239102 @default.
- W1751012597 cites W1963678818 @default.
- W1751012597 cites W1979174576 @default.
- W1751012597 cites W1983919608 @default.
- W1751012597 cites W1987506447 @default.
- W1751012597 cites W1987975969 @default.
- W1751012597 cites W2000938539 @default.
- W1751012597 cites W2001443196 @default.
- W1751012597 cites W2005056727 @default.
- W1751012597 cites W2010765148 @default.
- W1751012597 cites W2012008394 @default.
- W1751012597 cites W2013032292 @default.
- W1751012597 cites W2013360427 @default.
- W1751012597 cites W2023911475 @default.
- W1751012597 cites W2028953011 @default.
- W1751012597 cites W2030379432 @default.
- W1751012597 cites W2031456306 @default.
- W1751012597 cites W2032319312 @default.
- W1751012597 cites W2039481177 @default.
- W1751012597 cites W2041508767 @default.
- W1751012597 cites W2044411751 @default.
- W1751012597 cites W2045795253 @default.
- W1751012597 cites W2046467705 @default.
- W1751012597 cites W2052688181 @default.
- W1751012597 cites W2053362160 @default.
- W1751012597 cites W2061835812 @default.
- W1751012597 cites W2062264009 @default.
- W1751012597 cites W2062496875 @default.
- W1751012597 cites W2075631305 @default.
- W1751012597 cites W2075718119 @default.
- W1751012597 cites W2081994535 @default.
- W1751012597 cites W2082706183 @default.
- W1751012597 cites W2083458702 @default.
- W1751012597 cites W2084875329 @default.
- W1751012597 cites W2084992112 @default.
- W1751012597 cites W2085233944 @default.
- W1751012597 cites W2086925846 @default.
- W1751012597 cites W2102220689 @default.
- W1751012597 cites W2108736984 @default.
- W1751012597 cites W2111091913 @default.
- W1751012597 cites W2114492564 @default.
- W1751012597 cites W2114796502 @default.
- W1751012597 cites W2119151792 @default.
- W1751012597 cites W2123385823 @default.
- W1751012597 cites W2124597799 @default.
- W1751012597 cites W2131242974 @default.
- W1751012597 cites W2134286908 @default.
- W1751012597 cites W2138421443 @default.
- W1751012597 cites W2141716239 @default.
- W1751012597 cites W2142900503 @default.
- W1751012597 cites W2145356695 @default.
- W1751012597 cites W2155545390 @default.
- W1751012597 cites W2165848665 @default.
- W1751012597 cites W2166589385 @default.
- W1751012597 cites W2169693674 @default.
- W1751012597 cites W2315551924 @default.
- W1751012597 cites W2320229102 @default.
- W1751012597 cites W2330355806 @default.
- W1751012597 doi "https://doi.org/10.1089/jir.2013.0061" @default.
- W1751012597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24731196" @default.
- W1751012597 hasPublicationYear "2014" @default.
- W1751012597 type Work @default.
- W1751012597 sameAs 1751012597 @default.
- W1751012597 citedByCount "1" @default.
- W1751012597 countsByYear W17510125972020 @default.
- W1751012597 crossrefType "journal-article" @default.
- W1751012597 hasAuthorship W1751012597A5029919366 @default.
- W1751012597 hasAuthorship W1751012597A5034035769 @default.
- W1751012597 hasAuthorship W1751012597A5057395376 @default.
- W1751012597 hasAuthorship W1751012597A5065520980 @default.
- W1751012597 hasConcept C11960822 @default.
- W1751012597 hasConcept C153911025 @default.
- W1751012597 hasConcept C178666793 @default.
- W1751012597 hasConcept C179464577 @default.
- W1751012597 hasConcept C17991360 @default.
- W1751012597 hasConcept C181912034 @default.
- W1751012597 hasConcept C184235292 @default.
- W1751012597 hasConcept C185592680 @default.
- W1751012597 hasConcept C190283241 @default.
- W1751012597 hasConcept C203014093 @default.
- W1751012597 hasConcept C2776090121 @default.
- W1751012597 hasConcept C2776178377 @default.
- W1751012597 hasConcept C2777609662 @default.
- W1751012597 hasConcept C2779408958 @default.
- W1751012597 hasConcept C2779549131 @default.
- W1751012597 hasConcept C502942594 @default.
- W1751012597 hasConcept C55493867 @default.
- W1751012597 hasConcept C62478195 @default.
- W1751012597 hasConcept C75217442 @default.