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• W1751218746 abstract "The sequence of hepatitis B virus DNA contains an open reading frame which codes for a not-yet-identified protein of at least 389 amino acids. Only the products starting at the third (GP33/GP36) or the fourth (P24/GP27) initiation signal have been characterized as components of the viral surface antigen. We found a larger protein, P39, and its glycosylated form, GP42, in hepatitis B virus particles and viral surface antigen filaments. Immunological cross-reactions showed that P39/GP42 is partially homologous to P24/GP27 and GP33/GP36. The unique portion of its sequence bound monoclonal antibodies which had been induced by immunization with hepatitis B virus particles. Proteolytic cleavage patterns and subtype-specific size differences suggested that the sequence of P39 starts with the first initiation signal of the open reading frame. Its amino-terminal part (pre-s coded) is exposed at the viral surface and, probably, is highly immunogenic. A model is presented of how the open reading frame for the viral envelope leads to defined amounts of three different proteins." @default.
• W1751218746 created "2016-06-24" @default.
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• W1751218746 date "1984-11-01" @default.
• W1751218746 modified "2023-10-17" @default.
• W1751218746 title "Large surface proteins of hepatitis B virus containing the pre-s sequence" @default.
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• W1751218746 doi "https://doi.org/10.1128/jvi.52.2.396-402.1984" @default.
• W1751218746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/254539" @default.
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