FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W175134418> ?p ?o ?g. }

• W175134418 endingPage "285" @default.
• W175134418 startingPage "276" @default.
• W175134418 abstract "Loss of kidney graft function with tubular atrophy (TA) and interstitial fibrosis (IF) causes most kidney allograft losses. We aimed to identify the molecular pathways involved in IF/TA progression. Kidney biopsies from normal kidneys (n = 24), normal allografts (n = 6), and allografts with IF/TA (n = 17) were analyzed using high-density oligonucleotide microarray. Probe set level tests of hypotheses tests were conducted to identify genes with a significant trend in gene expression across the three groups using Jonckheere-Terpstra test for trend. Interaction networks and functional analysis were used. An unsupervised hierarchical clustering analysis showed that all the IF/TA samples were associated with high correlation. Gene ontology classified the differentially expressed genes as related to immune response, inflammation, and matrix deposition. Chemokines (CX), CX receptor (for example, CCL5 and CXCR4), interleukin, and interleukin receptor (for example, IL-8 and IL10RA) genes were overexpressed in IF/TA samples compared with normal allografts and normal kidneys. Genes involved in apoptosis (for example, CASP4 and CASP5) were importantly overexpressed in IF/TA. Genes related to angiogenesis (for example, ANGPTL3, ANGPT2, and VEGF) were downregulated in IF/TA. Genes related to matrix production-deposition were upregulated in IF/TA. A distinctive gene expression pattern was observed in IF/TA samples compared with normal allografts and normal kidneys. We were able to establish a trend in gene expression for genes involved in different pathways among the studied groups. The top-scored networks were related to immune response, inflammation, and cell-to-cell interaction, showing the importance of chronic inflammation in progressive graft deterioration." @default.
• W175134418 created "2016-06-24" @default.
• W175134418 creator A5006928350 @default.
• W175134418 creator A5019144916 @default.
• W175134418 creator A5019286453 @default.
• W175134418 creator A5019972826 @default.
• W175134418 creator A5029834103 @default.
• W175134418 creator A5044993368 @default.
• W175134418 creator A5070476953 @default.
• W175134418 creator A5073578618 @default.
• W175134418 creator A5087009545 @default.
• W175134418 date "2008-02-07" @default.
• W175134418 modified "2023-10-13" @default.
• W175134418 title "Molecular Pathways Involved in Loss of Kidney Graft Function with Tubular Atrophy and Interstitial Fibrosis" @default.
• W175134418 cites W1533335653 @default.
• W175134418 cites W1973893754 @default.
• W175134418 cites W1984221579 @default.
• W175134418 cites W1987239774 @default.
• W175134418 cites W1988700063 @default.
• W175134418 cites W1995388702 @default.
• W175134418 cites W1995791071 @default.
• W175134418 cites W2005571837 @default.
• W175134418 cites W2014970204 @default.
• W175134418 cites W2018927926 @default.
• W175134418 cites W2019012138 @default.
• W175134418 cites W2021174262 @default.
• W175134418 cites W2030774568 @default.
• W175134418 cites W2031288086 @default.
• W175134418 cites W2038732581 @default.
• W175134418 cites W2048571115 @default.
• W175134418 cites W2058019632 @default.
• W175134418 cites W2059579815 @default.
• W175134418 cites W2077736762 @default.
• W175134418 cites W2083018858 @default.
• W175134418 cites W2085814708 @default.
• W175134418 cites W2098974363 @default.
• W175134418 cites W2106403351 @default.
• W175134418 cites W2107277218 @default.
• W175134418 cites W2107336112 @default.
• W175134418 cites W2109972881 @default.
• W175134418 cites W2114634566 @default.
• W175134418 cites W2123607535 @default.
• W175134418 cites W2125959011 @default.
• W175134418 cites W2138620116 @default.
• W175134418 cites W2152294840 @default.
• W175134418 cites W2159628746 @default.
• W175134418 cites W2162871532 @default.
• W175134418 cites W2164096901 @default.
• W175134418 cites W2170264508 @default.
• W175134418 cites W2171871452 @default.
• W175134418 cites W2333378480 @default.
• W175134418 cites W4213297656 @default.
• W175134418 doi "https://doi.org/10.2119/2007-00111.maluf" @default.
• W175134418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2242778" @default.
• W175134418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18286166" @default.
• W175134418 hasPublicationYear "2008" @default.
• W175134418 type Work @default.
• W175134418 sameAs 175134418 @default.
• W175134418 citedByCount "51" @default.
• W175134418 countsByYear W1751344182012 @default.
• W175134418 countsByYear W1751344182013 @default.
• W175134418 countsByYear W1751344182014 @default.
• W175134418 countsByYear W1751344182015 @default.
• W175134418 countsByYear W1751344182016 @default.
• W175134418 countsByYear W1751344182017 @default.
• W175134418 countsByYear W1751344182018 @default.
• W175134418 countsByYear W1751344182019 @default.
• W175134418 countsByYear W1751344182020 @default.
• W175134418 countsByYear W1751344182021 @default.
• W175134418 countsByYear W1751344182022 @default.
• W175134418 countsByYear W1751344182023 @default.
• W175134418 crossrefType "journal-article" @default.
• W175134418 hasAuthorship W175134418A5006928350 @default.
• W175134418 hasAuthorship W175134418A5019144916 @default.
• W175134418 hasAuthorship W175134418A5019286453 @default.
• W175134418 hasAuthorship W175134418A5019972826 @default.
• W175134418 hasAuthorship W175134418A5029834103 @default.
• W175134418 hasAuthorship W175134418A5044993368 @default.
• W175134418 hasAuthorship W175134418A5070476953 @default.
• W175134418 hasAuthorship W175134418A5073578618 @default.
• W175134418 hasAuthorship W175134418A5087009545 @default.
• W175134418 hasBestOaLocation W1751344181 @default.
• W175134418 hasConcept C104317684 @default.
• W175134418 hasConcept C142724271 @default.
• W175134418 hasConcept C150194340 @default.
• W175134418 hasConcept C203014093 @default.
• W175134418 hasConcept C2776914184 @default.
• W175134418 hasConcept C2780091579 @default.
• W175134418 hasConcept C2780394083 @default.
• W175134418 hasConcept C2780559512 @default.
• W175134418 hasConcept C502942594 @default.
• W175134418 hasConcept C54355233 @default.
• W175134418 hasConcept C71924100 @default.
• W175134418 hasConcept C8415881 @default.
• W175134418 hasConcept C86803240 @default.
• W175134418 hasConcept C8891405 @default.
• W175134418 hasConcept C95444343 @default.
• W175134418 hasConceptScore W175134418C104317684 @default.

• next