FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1751363906> ?p ?o ?g. }

• W1751363906 endingPage "7" @default.
• W1751363906 startingPage "401" @default.
• W1751363906 abstract "The following possible explanations for the significant increases in the oral bioavailability and the diuretic and natriuretic effects of orally administered furosemide observed when ascorbic acid was coadministered to dogs were investigated: ascorbic acid might enhance the gastrointestinal (GI) absorption of furosemide, might inhibit GI wall metabolism of furosemide, might enhance the reabsorption of furosemide from the renal tubules, and might increase the unionized fraction of furosemide at the receptor sites. The significant increase in the oral bioavailability with coadministration of ascorbic acid seemed to result from reduced gastric first-pass metabolism of furosemide and not enhanced GI absorption of furosemide. This might be supported by rat studies; the percentages of the oral doses of furosemide recovered from the GI tract at 8 hr after oral administration were similar (p < 0.583) without (39.5%) and with (44.7%) coadministration of ascorbic acid, and the amounts of furosemide remaining per gram of stomach after 30-min incubations of 50 micrograms of furosemide with 9000g supernatant fractions of stomach homogenates were increased significantly (48.5 vs. 42.4 micrograms) by the addition of 100 micrograms of ascorbic acid. The significant increases in the diuretic and natriuretic effects of furosemide with ascorbic acid could be the result of increases in the reabsorption of furosemide from renal tubules and increases in the unionized fraction of furosemide at the renal tubular receptor sites. This was supported by 1.5-4.2-fold increases in urine output and approximately 20% decreases in the time-averaged renal clearance of furosemide when the urine pH was decreased by 1.5-2.5 units by oral administration of ammonium chloride." @default.
• W1751363906 created "2016-06-24" @default.
• W1751363906 creator A5020089433 @default.
• W1751363906 creator A5034042915 @default.
• W1751363906 date "1998-05-01" @default.
• W1751363906 modified "2023-09-23" @default.
• W1751363906 title "Mechanism of ascorbic acid enhancement of the bioavailability and diuretic effect of furosemide." @default.
• W1751363906 cites W1838216884 @default.
• W1751363906 cites W1914054245 @default.
• W1751363906 cites W1963621910 @default.
• W1751363906 cites W1963915050 @default.
• W1751363906 cites W1975973865 @default.
• W1751363906 cites W1997596864 @default.
• W1751363906 cites W2010590840 @default.
• W1751363906 cites W2016351075 @default.
• W1751363906 cites W2025793933 @default.
• W1751363906 cites W2035163935 @default.
• W1751363906 cites W2057808028 @default.
• W1751363906 cites W2063174783 @default.
• W1751363906 cites W2064733122 @default.
• W1751363906 cites W2066806870 @default.
• W1751363906 cites W2068628316 @default.
• W1751363906 cites W2073635482 @default.
• W1751363906 cites W2073878312 @default.
• W1751363906 cites W2074302956 @default.
• W1751363906 cites W2074499292 @default.
• W1751363906 cites W2075827074 @default.
• W1751363906 cites W2086135486 @default.
• W1751363906 cites W2087057481 @default.
• W1751363906 cites W2093064121 @default.
• W1751363906 cites W2107808387 @default.
• W1751363906 cites W2119421913 @default.
• W1751363906 cites W2119649509 @default.
• W1751363906 cites W2147857763 @default.
• W1751363906 cites W2155223429 @default.
• W1751363906 cites W2213501008 @default.
• W1751363906 cites W2246158009 @default.
• W1751363906 cites W2252991923 @default.
• W1751363906 cites W2257251339 @default.
• W1751363906 cites W2401296670 @default.
• W1751363906 cites W2419592800 @default.
• W1751363906 cites W2471014136 @default.
• W1751363906 cites W3174737354 @default.
• W1751363906 cites W2807359548 @default.
• W1751363906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9571221" @default.
• W1751363906 hasPublicationYear "1998" @default.
• W1751363906 type Work @default.
• W1751363906 sameAs 1751363906 @default.
• W1751363906 citedByCount "3" @default.
• W1751363906 countsByYear W17513639062015 @default.
• W1751363906 countsByYear W17513639062016 @default.
• W1751363906 crossrefType "journal-article" @default.
• W1751363906 hasAuthorship W1751363906A5020089433 @default.
• W1751363906 hasAuthorship W1751363906A5034042915 @default.
• W1751363906 hasConcept C112705442 @default.
• W1751363906 hasConcept C126322002 @default.
• W1751363906 hasConcept C134018914 @default.
• W1751363906 hasConcept C161457703 @default.
• W1751363906 hasConcept C181389837 @default.
• W1751363906 hasConcept C185592680 @default.
• W1751363906 hasConcept C2777056448 @default.
• W1751363906 hasConcept C2777955127 @default.
• W1751363906 hasConcept C2779422922 @default.
• W1751363906 hasConcept C2779918671 @default.
• W1751363906 hasConcept C2780091579 @default.
• W1751363906 hasConcept C2986274086 @default.
• W1751363906 hasConcept C31903555 @default.
• W1751363906 hasConcept C55493867 @default.
• W1751363906 hasConcept C56906281 @default.
• W1751363906 hasConcept C71924100 @default.
• W1751363906 hasConcept C97320921 @default.
• W1751363906 hasConcept C98274493 @default.
• W1751363906 hasConceptScore W1751363906C112705442 @default.
• W1751363906 hasConceptScore W1751363906C126322002 @default.
• W1751363906 hasConceptScore W1751363906C134018914 @default.
• W1751363906 hasConceptScore W1751363906C161457703 @default.
• W1751363906 hasConceptScore W1751363906C181389837 @default.
• W1751363906 hasConceptScore W1751363906C185592680 @default.
• W1751363906 hasConceptScore W1751363906C2777056448 @default.
• W1751363906 hasConceptScore W1751363906C2777955127 @default.
• W1751363906 hasConceptScore W1751363906C2779422922 @default.
• W1751363906 hasConceptScore W1751363906C2779918671 @default.
• W1751363906 hasConceptScore W1751363906C2780091579 @default.
• W1751363906 hasConceptScore W1751363906C2986274086 @default.
• W1751363906 hasConceptScore W1751363906C31903555 @default.
• W1751363906 hasConceptScore W1751363906C55493867 @default.
• W1751363906 hasConceptScore W1751363906C56906281 @default.
• W1751363906 hasConceptScore W1751363906C71924100 @default.
• W1751363906 hasConceptScore W1751363906C97320921 @default.
• W1751363906 hasConceptScore W1751363906C98274493 @default.
• W1751363906 hasIssue "5" @default.
• W1751363906 hasLocation W17513639061 @default.
• W1751363906 hasOpenAccess W1751363906 @default.
• W1751363906 hasPrimaryLocation W17513639061 @default.
• W1751363906 hasRelatedWork W1526899296 @default.
• W1751363906 hasRelatedWork W1615746932 @default.
• W1751363906 hasRelatedWork W1751363906 @default.
• W1751363906 hasRelatedWork W2001933224 @default.

• next