FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1751366399> ?p ?o ?g. }

• W1751366399 abstract "Sexual dimorphisms in adrenal function and distinct behavioral patterns of aggression and “emotionality” in SJL and C57/BL6 mouse strains led to an intriguing question: are there strainand/or gender-specific differences in the adrenal gland at the level of ion channels? In this study, we focused on the adrenal medulla, which is a critical component of the neuroendocrine system and responsible for modulating reactions to stress and regulation of various body processes including digestion, the immune system, mood, and energy usage. Secretion of epinephrine (EPI) from chromaffin cells of the adrenal medulla is tightly controlled by the electrophysiologial response generated from neural inputs. Several studies suggest that the intrinsic excitability of these cells is modulated by the number and kenetic properties of large-conductance calcium(2+)activated potassium ion channels (BK channels). Therefore, we focused on BK channels to study strainand gender-specific differences in the adrenal gland at the level of ion channels. Stressand sex-steroids have been shown to regulate alternative splicing of the pore-forming subunit of BK channels (Slo-α) in several experimental contexts, and associated β-subunits confer on BK channels distinct sensitivities to acute effects of stressand sex-steroids. Using a real-time PCR technique, we examined mRNA levels for total Slo, STREX (a stress-regulated splice-variant of Slo), β2, and β4 in two mouse strains, SJL and C57/BL6. The experimental groups were: SJL males, SJL females, and C57/BL6 males. SJL males expressed significantly higher levels of mRNA for total Slo, β2, and β4 than SJL females and C57/BL6 males. STREX levels were not significantly different between the groups, probably due to a small sample size, but on average, SJL males had higher levels of expression than the other two groups. These results suggest" @default.
• W1751366399 created "2016-06-24" @default.
• W1751366399 creator A5074447386 @default.
• W1751366399 date "2007-06-27" @default.
• W1751366399 modified "2023-09-27" @default.
• W1751366399 title "Strain and Gender Differences in Expression of BK Potassium Channel Subunits in Mouse Adrenal Gland" @default.
• W1751366399 cites W1509820321 @default.
• W1751366399 cites W1517099987 @default.
• W1751366399 cites W1519473643 @default.
• W1751366399 cites W1886320289 @default.
• W1751366399 cites W1965794966 @default.
• W1751366399 cites W1968001391 @default.
• W1751366399 cites W1975310820 @default.
• W1751366399 cites W1977728606 @default.
• W1751366399 cites W1983255899 @default.
• W1751366399 cites W1992796744 @default.
• W1751366399 cites W2006983248 @default.
• W1751366399 cites W2007372862 @default.
• W1751366399 cites W2011608196 @default.
• W1751366399 cites W2018898149 @default.
• W1751366399 cites W2018981746 @default.
• W1751366399 cites W2029274601 @default.
• W1751366399 cites W2048047184 @default.
• W1751366399 cites W2062111719 @default.
• W1751366399 cites W2063845237 @default.
• W1751366399 cites W2084691692 @default.
• W1751366399 cites W2089157424 @default.
• W1751366399 cites W2090033907 @default.
• W1751366399 cites W2107684488 @default.
• W1751366399 cites W2141832664 @default.
• W1751366399 cites W2158010642 @default.
• W1751366399 cites W2313100941 @default.
• W1751366399 cites W2324704831 @default.
• W1751366399 cites W2993290797 @default.
• W1751366399 cites W2472798782 @default.
• W1751366399 hasPublicationYear "2007" @default.
• W1751366399 type Work @default.
• W1751366399 sameAs 1751366399 @default.
• W1751366399 citedByCount "0" @default.
• W1751366399 crossrefType "dissertation" @default.
• W1751366399 hasAuthorship W1751366399A5074447386 @default.
• W1751366399 hasConcept C104317684 @default.
• W1751366399 hasConcept C105580179 @default.
• W1751366399 hasConcept C126322002 @default.
• W1751366399 hasConcept C127716648 @default.
• W1751366399 hasConcept C134018914 @default.
• W1751366399 hasConcept C17291353 @default.
• W1751366399 hasConcept C194583182 @default.
• W1751366399 hasConcept C2775894120 @default.
• W1751366399 hasConcept C2777597313 @default.
• W1751366399 hasConcept C2780694816 @default.
• W1751366399 hasConcept C54355233 @default.
• W1751366399 hasConcept C61144316 @default.
• W1751366399 hasConcept C71924100 @default.
• W1751366399 hasConcept C83743174 @default.
• W1751366399 hasConcept C86803240 @default.
• W1751366399 hasConcept C95444343 @default.
• W1751366399 hasConceptScore W1751366399C104317684 @default.
• W1751366399 hasConceptScore W1751366399C105580179 @default.
• W1751366399 hasConceptScore W1751366399C126322002 @default.
• W1751366399 hasConceptScore W1751366399C127716648 @default.
• W1751366399 hasConceptScore W1751366399C134018914 @default.
• W1751366399 hasConceptScore W1751366399C17291353 @default.
• W1751366399 hasConceptScore W1751366399C194583182 @default.
• W1751366399 hasConceptScore W1751366399C2775894120 @default.
• W1751366399 hasConceptScore W1751366399C2777597313 @default.
• W1751366399 hasConceptScore W1751366399C2780694816 @default.
• W1751366399 hasConceptScore W1751366399C54355233 @default.
• W1751366399 hasConceptScore W1751366399C61144316 @default.
• W1751366399 hasConceptScore W1751366399C71924100 @default.
• W1751366399 hasConceptScore W1751366399C83743174 @default.
• W1751366399 hasConceptScore W1751366399C86803240 @default.
• W1751366399 hasConceptScore W1751366399C95444343 @default.
• W1751366399 hasLocation W17513663991 @default.
• W1751366399 hasOpenAccess W1751366399 @default.
• W1751366399 hasPrimaryLocation W17513663991 @default.
• W1751366399 hasRelatedWork W109192066 @default.
• W1751366399 hasRelatedWork W1991092840 @default.
• W1751366399 hasRelatedWork W1999808241 @default.
• W1751366399 hasRelatedWork W2031211185 @default.
• W1751366399 hasRelatedWork W2062428457 @default.
• W1751366399 hasRelatedWork W2082952610 @default.
• W1751366399 hasRelatedWork W2093190487 @default.
• W1751366399 hasRelatedWork W2165023132 @default.
• W1751366399 isParatext "false" @default.
• W1751366399 isRetracted "false" @default.
• W1751366399 magId "1751366399" @default.
• W1751366399 workType "dissertation" @default.