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• W175162743 abstract "An oligodeoxynucleotide duplex containing the chemotherapeutic agent 5-fluorouracil (FU) has been constructed by solid phase phosphotriester synthesis and has been studied in solution by proton NMR. In this study, we provide the first structural characterization of a DNA complex containing a FU.A base pair. It has been determined that the 7-mer duplex containing a central FU.A base pair adopts a normal right-handed configuration and the A residue in the FU.A pair is oriented in the normal anticonfiguration giving a Watson-Crick base pair. The significant difference between T.A and FU.A base pairs is dynamic, not structural: the FU.A base pair opens faster than normal base pairs in the oligonucleotide studied. We provide evidence that the FU.A base pair has a significantly enhanced opening rate resulting form decreased stacking of the 5-fluorouracil residue and not from the enhanced acidity of the 5'-fluorouracil imino proton." @default.
• W175162743 created "2016-06-24" @default.
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• W175162743 date "1987-11-01" @default.
• W175162743 modified "2023-10-17" @default.
• W175162743 title "Structural and dynamic properties of a fluorouracil-adenine base pair in DNA studied by proton NMR." @default.
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• W175162743 doi "https://doi.org/10.1016/s0021-9258(18)47745-9" @default.
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