FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1751924468> ?p ?o ?g. }

• W1751924468 endingPage "125" @default.
• W1751924468 startingPage "119" @default.
• W1751924468 abstract "In this paper, we present the technology of synthesis, characterization and release kinetics of anticancer drug molecules from sandwich-like mesoporous silica nanoflakes. Mesoporous silica nanoflakes are a very attractive material due to their versatility, low cytotoxicity, large surface area, high pore volume and unique feature of containing parallel pores openon both sides. Nanosilica flakes were prepared through the formation of a mesoporous silica layer on a graphene oxide surface. After graphene oxide removal, the silica nanostructures were filled by an anticancer drug—methotrexate. Release kinetics studies were performed in different temperatures, imitating the conditions in living organisms. Release data was analyzed using the zero-order model, first-order model, Higuchi model and Korsmeyer-Peppas model. The optical properties of samples, and the kinetics of drug release from the nanostructure, were examined by UV–vis spectrophotometer. Data obtained from long term studies showed that the system can serve as an anticancer drug carrier system, since a significant amount of methotrexate was loaded to the material and released. The mechanism of MTX release from mesoporous silica nanoflakes appeared to be a parallel processes of diffusion through water-filled mesopores and degradation of the mSiO2 matrix. Physical and chemical characterization was undertaken by transmission electron microscopy (TEM) and X-ray dispersion spectroscopy (EDX). The specific surface area of the samples was measured through the adsorption of N2 isotherm, interpreted with the Brunauer–Emmett–Teller model (BET). TGA and UV–vis analyses were conducted in order to estimate the amount of the released drug." @default.
• W1751924468 created "2016-06-24" @default.
• W1751924468 creator A5051008159 @default.
• W1751924468 creator A5059167992 @default.
• W1751924468 creator A5064148144 @default.
• W1751924468 creator A5086702831 @default.
• W1751924468 date "2015-12-01" @default.
• W1751924468 modified "2023-09-26" @default.
• W1751924468 title "Sandwich-like mesoporous silica flakes for anticancer drug transport—Synthesis, characterization and kinetics release study" @default.
• W1751924468 cites W1967901144 @default.
• W1751924468 cites W1969313870 @default.
• W1751924468 cites W1970216602 @default.
• W1751924468 cites W1976787731 @default.
• W1751924468 cites W1983327991 @default.
• W1751924468 cites W1989037178 @default.
• W1751924468 cites W1991195879 @default.
• W1751924468 cites W2000205238 @default.
• W1751924468 cites W2007031179 @default.
• W1751924468 cites W2010671046 @default.
• W1751924468 cites W2026972453 @default.
• W1751924468 cites W2038379069 @default.
• W1751924468 cites W2039241045 @default.
• W1751924468 cites W2043931953 @default.
• W1751924468 cites W2060009331 @default.
• W1751924468 cites W2067882794 @default.
• W1751924468 cites W2070517548 @default.
• W1751924468 cites W2072249032 @default.
• W1751924468 cites W2072829987 @default.
• W1751924468 cites W2079392632 @default.
• W1751924468 cites W2106192448 @default.
• W1751924468 cites W2109477306 @default.
• W1751924468 cites W2112272805 @default.
• W1751924468 cites W2152752812 @default.
• W1751924468 cites W2153148867 @default.
• W1751924468 cites W2157265727 @default.
• W1751924468 cites W2162525853 @default.
• W1751924468 cites W2165032254 @default.
• W1751924468 cites W2170446261 @default.
• W1751924468 cites W2316044337 @default.
• W1751924468 cites W2330347920 @default.
• W1751924468 doi "https://doi.org/10.1016/j.colsurfb.2015.09.007" @default.
• W1751924468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26381695" @default.
• W1751924468 hasPublicationYear "2015" @default.
• W1751924468 type Work @default.
• W1751924468 sameAs 1751924468 @default.
• W1751924468 citedByCount "13" @default.
• W1751924468 countsByYear W17519244682016 @default.
• W1751924468 countsByYear W17519244682018 @default.
• W1751924468 countsByYear W17519244682019 @default.
• W1751924468 countsByYear W17519244682020 @default.
• W1751924468 countsByYear W17519244682021 @default.
• W1751924468 countsByYear W17519244682023 @default.
• W1751924468 crossrefType "journal-article" @default.
• W1751924468 hasAuthorship W1751924468A5051008159 @default.
• W1751924468 hasAuthorship W1751924468A5059167992 @default.
• W1751924468 hasAuthorship W1751924468A5064148144 @default.
• W1751924468 hasAuthorship W1751924468A5086702831 @default.
• W1751924468 hasConcept C121332964 @default.
• W1751924468 hasConcept C127413603 @default.
• W1751924468 hasConcept C148898269 @default.
• W1751924468 hasConcept C150394285 @default.
• W1751924468 hasConcept C161790260 @default.
• W1751924468 hasConcept C171250308 @default.
• W1751924468 hasConcept C178790620 @default.
• W1751924468 hasConcept C185592680 @default.
• W1751924468 hasConcept C186187911 @default.
• W1751924468 hasConcept C191897082 @default.
• W1751924468 hasConcept C192562407 @default.
• W1751924468 hasConcept C2777496208 @default.
• W1751924468 hasConcept C2779851234 @default.
• W1751924468 hasConcept C30080830 @default.
• W1751924468 hasConcept C42360764 @default.
• W1751924468 hasConcept C62520636 @default.
• W1751924468 hasConcept C82776694 @default.
• W1751924468 hasConceptScore W1751924468C121332964 @default.
• W1751924468 hasConceptScore W1751924468C127413603 @default.
• W1751924468 hasConceptScore W1751924468C148898269 @default.
• W1751924468 hasConceptScore W1751924468C150394285 @default.
• W1751924468 hasConceptScore W1751924468C161790260 @default.
• W1751924468 hasConceptScore W1751924468C171250308 @default.
• W1751924468 hasConceptScore W1751924468C178790620 @default.
• W1751924468 hasConceptScore W1751924468C185592680 @default.
• W1751924468 hasConceptScore W1751924468C186187911 @default.
• W1751924468 hasConceptScore W1751924468C191897082 @default.
• W1751924468 hasConceptScore W1751924468C192562407 @default.
• W1751924468 hasConceptScore W1751924468C2777496208 @default.
• W1751924468 hasConceptScore W1751924468C2779851234 @default.
• W1751924468 hasConceptScore W1751924468C30080830 @default.
• W1751924468 hasConceptScore W1751924468C42360764 @default.
• W1751924468 hasConceptScore W1751924468C62520636 @default.
• W1751924468 hasConceptScore W1751924468C82776694 @default.
• W1751924468 hasLocation W17519244681 @default.
• W1751924468 hasLocation W17519244682 @default.
• W1751924468 hasOpenAccess W1751924468 @default.
• W1751924468 hasPrimaryLocation W17519244681 @default.
• W1751924468 hasRelatedWork W1986518204 @default.
• W1751924468 hasRelatedWork W2134948224 @default.
• W1751924468 hasRelatedWork W2137163290 @default.

• next