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- W1752014911 abstract "Sterile inflammation is a common finding present in various metabolic disorders. This type of inflammation is mediated by damage-associated molecular patterns (DAMPs) that are released upon cellular injury to activate pattern recognition receptors on innate immune cells and amplify organ damage.In the last decade, DAMPs, such as high-mobility group protein B1, nucleic acids (DNA, RNA), adenosine triphosphate, and other metabolites, were found to contribute to the inflammatory response in diabetes, gout, obesity, steatohepatitis, and atherosclerosis. Varied receptors, including Toll-like receptors (TLRs), the purinergic P2X(7) receptors, and nucleotide-binding domain, and leucine-rich repeat protein 3 (NLRP3)-inflammasome sense DAMPs and DAMP-like molecules and release the proinflammatory cytokines, interleukin (IL)-1β and IL-18.Available therapeutic approaches that interfered with the signaling of TLRs, P2X(7), NLRP3-inflammasome, and IL-1β showed encouraging results in metabolic diseases, which will be also highlighted in this review.It is important to understand the origination of DAMPs and how they contribute to the inflammatory response in metabolic disorders to develop selective and efficient therapeutics for intervention." @default.
- W1752014911 created "2016-06-24" @default.
- W1752014911 creator A5021200402 @default.
- W1752014911 creator A5026158762 @default.
- W1752014911 creator A5059996727 @default.
- W1752014911 date "2015-12-10" @default.
- W1752014911 modified "2023-10-17" @default.
- W1752014911 title "Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases" @default.
- W1752014911 cites W1529674879 @default.
- W1752014911 cites W1886167013 @default.
- W1752014911 cites W190744314 @default.
- W1752014911 cites W1963766592 @default.
- W1752014911 cites W1964876127 @default.
- W1752014911 cites W1967412131 @default.
- W1752014911 cites W1968955229 @default.
- W1752014911 cites W1969981758 @default.
- W1752014911 cites W1972204333 @default.
- W1752014911 cites W1972483153 @default.
- W1752014911 cites W1974033843 @default.
- W1752014911 cites W1974885063 @default.
- W1752014911 cites W1985598247 @default.
- W1752014911 cites W1988870963 @default.
- W1752014911 cites W1989141886 @default.
- W1752014911 cites W1990113288 @default.
- W1752014911 cites W1991920989 @default.
- W1752014911 cites W1992024672 @default.
- W1752014911 cites W1992789370 @default.
- W1752014911 cites W1993197717 @default.
- W1752014911 cites W1993877349 @default.
- W1752014911 cites W1995164074 @default.
- W1752014911 cites W1998156781 @default.
- W1752014911 cites W1998221258 @default.
- W1752014911 cites W2000054651 @default.
- W1752014911 cites W2000323986 @default.
- W1752014911 cites W2001131819 @default.
- W1752014911 cites W2003483275 @default.
- W1752014911 cites W2004981017 @default.
- W1752014911 cites W2008261126 @default.
- W1752014911 cites W2009004909 @default.
- W1752014911 cites W2009800174 @default.
- W1752014911 cites W2013177932 @default.
- W1752014911 cites W2015449243 @default.
- W1752014911 cites W2016349594 @default.
- W1752014911 cites W2017678782 @default.
- W1752014911 cites W2018563185 @default.
- W1752014911 cites W2018607502 @default.
- W1752014911 cites W2018653121 @default.
- W1752014911 cites W2028519649 @default.
- W1752014911 cites W2029068688 @default.
- W1752014911 cites W2029861821 @default.
- W1752014911 cites W2034112923 @default.
- W1752014911 cites W2051303794 @default.
- W1752014911 cites W2052663559 @default.
- W1752014911 cites W2054625009 @default.
- W1752014911 cites W2054784071 @default.
- W1752014911 cites W2055132644 @default.
- W1752014911 cites W2057237586 @default.
- W1752014911 cites W2060157902 @default.
- W1752014911 cites W2063218223 @default.
- W1752014911 cites W2066035628 @default.
- W1752014911 cites W2066160102 @default.
- W1752014911 cites W2066904343 @default.
- W1752014911 cites W2074401812 @default.
- W1752014911 cites W2077905680 @default.
- W1752014911 cites W2079778407 @default.
- W1752014911 cites W2080107084 @default.
- W1752014911 cites W2080717362 @default.
- W1752014911 cites W2082814058 @default.
- W1752014911 cites W2085153086 @default.
- W1752014911 cites W2089532303 @default.
- W1752014911 cites W2090859543 @default.
- W1752014911 cites W2092157690 @default.
- W1752014911 cites W2095917499 @default.
- W1752014911 cites W2096921043 @default.
- W1752014911 cites W2101076088 @default.
- W1752014911 cites W2101118037 @default.
- W1752014911 cites W2102683312 @default.
- W1752014911 cites W2104414795 @default.
- W1752014911 cites W2111410554 @default.
- W1752014911 cites W2118011548 @default.
- W1752014911 cites W2120815988 @default.
- W1752014911 cites W2121560754 @default.
- W1752014911 cites W2122297353 @default.
- W1752014911 cites W2123195857 @default.
- W1752014911 cites W2128464705 @default.
- W1752014911 cites W2129224427 @default.
- W1752014911 cites W2130495917 @default.
- W1752014911 cites W2130989367 @default.
- W1752014911 cites W2132280604 @default.
- W1752014911 cites W2133052709 @default.
- W1752014911 cites W2134007048 @default.
- W1752014911 cites W2135359579 @default.
- W1752014911 cites W2135711139 @default.
- W1752014911 cites W2135791851 @default.
- W1752014911 cites W2138175677 @default.
- W1752014911 cites W2139552156 @default.
- W1752014911 cites W2139833921 @default.
- W1752014911 cites W2140637559 @default.