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- W1752735880 abstract "Abstract Background and Aim Sorafenib is now considered as a standard treatment for advanced hepatocellular carcinoma ( HCC ). We evaluated the effect of hepatitis B virus ( HBV ) DNA titers on prognosis in HCC patients treated with sorafenib. Methods From 2008 to 2012, 78 HBV ‐related HCC patients who received sorafenib treatment at S everance H ospital were included in our analysis. The effect of pretreatment HBV ‐ DNA levels on clinical outcomes for use in predicting prognosis after treatment with sorafenib was examined by univariate and multivariate analysis. Results Median overall survival and median progression‐free survival were 5.2 months (95% confidence interval: 4.0–6.4) and 3.5 months (95% confidence interval: 2.3–4.7), respectively. Multivariate analysis revealed high levels of HBV ‐ DNA (> 2000 IU/mL ) to be an independent risk factor for worse overall survival ( P = 0.005; hazard ratio, 2.85) and disease progression among patients who did not receive concomitant prophylactic antiviral therapy during sorafenib treatment ( P = 0.008; hazard ratio, 87.4). Moreover, viral reactivation occurred more frequently in patients who did not receive concomitant prophylactic antiviral therapy than in those who did (4/38 vs 0/40; P = 0.025). Conclusion Higher HBV ‐ DNA levels prior to sorafenib treatment were associated with poorer prognosis and increased viral reactivation thereafter. These results suggest the potential usefulness of prophylactic antiviral therapy when treating HBV ‐related HCC patients with sorafenib." @default.
- W1752735880 created "2016-06-24" @default.
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- W1752735880 date "2015-04-27" @default.
- W1752735880 modified "2023-10-03" @default.
- W1752735880 title "Hepatitis B viral load predicts survival in hepatocellular carcinoma patients treated with sorafenib" @default.
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- W1752735880 doi "https://doi.org/10.1111/jgh.12898" @default.
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