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- W17531916 abstract "Antisense oligodeoxynucleotides (AS-ODNs) are oligomers—typically 14–30 nucleotides long- of single-stranded DNA, or DNA analogs chemically modified for the purpose of increasing stability. If translation, in one manner or another, is inhibited by AS-ODNs, proteins expressed at low levels and subjected to a continuous turnover should constitute targets well suited for antisense inhibition. Another suitable type of target would be proteins, which are not at all expressed constitutively, but only transiently induced. Receptor antagonists are only available for a minority of receptor active brain messengers, mainly those belonging to the small-molecular transmitter families, or the classical transmitters. The feasibility of time- and dose-dependently blocking c-fos expression in the brain by a single localized injection of a phosphorothioate AS-ODN directly into the target area is elaborated. In mammalian cells, RNase H plays a minor if any role for the activity of AS-ODNs. AS-ODNs can down-regulate a specific gene product without causing a degradation of the corresponding mRNA in a variety of mammalian cell types, including neurons in vivo." @default.
- W17531916 created "2016-06-24" @default.
- W17531916 creator A5007980662 @default.
- W17531916 creator A5087240695 @default.
- W17531916 date "1995-01-01" @default.
- W17531916 modified "2023-10-01" @default.
- W17531916 title "Antisense oligodeoxynucleotides as novel neuropharmacological tools for selective expression blockade in the brain" @default.
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- W17531916 doi "https://doi.org/10.1016/b978-012437165-1/50017-2" @default.
- W17531916 hasPublicationYear "1995" @default.
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