FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1753314883> ?p ?o ?g. }

• W1753314883 endingPage "572" @default.
• W1753314883 startingPage "564" @default.
• W1753314883 abstract "ABSTRACT: Cystatin C displays the strongest inhibitory activity of all cystatins toward lysosomal cysteine proteases in general and has a widespread distribution in human tissues and body fluids, including seminal plasma. The aim of this study was to investigate the distribution of cystatin C in the male reproductive system. Immunohistochemistry revealed a widespread distribution of cystatin C in normal tissues from the testis, epididymis, vas deferens, seminal vesicle, and prostate gland. Immunoreactive cystatin C was localized in basal and secretory epithelial cells, but also in neuroendocrine cells in the prostate, identified by immunostaining for chromogranin A. On adjacent tissue sections, we demonstrated local production of cystatin C utilizing nonradioactive in situ hybridization with a 201-base-long digoxigenin-labeled antisense RNA probe specific for the cystatin C transcript. Staining patterns obtained by immunohistochemistry and in situ hybridization correlated well. Enzyme-linked immunosorbent assay for quantitative analysis of cystatin C demonstrated that cystatin C was present at high concentrations in tissue homogenates from all locations investigated, compared to liver, muscle, spleen, and other general tissues. Western blotting of tissue homogenates revealed a predominant 15-kd cystatin C immunoreactive component in accordance with previous findings in other organs. Quantitative real-time polymerase chain reaction analysis to determine messenger RNA levels in whole tissue extracts showed that the cystatin C gene is highly expressed in the seminal vesicles and the prostate gland, indicating that the major amount of cystatin C in the male reproductive organs and seminal plasma is produced by cells in these 2 tissues. It is concluded that cystatin C is highly expressed and widely distributed throughout the male genital tract, suggesting that cystatin C is an important regulator for normal and pathological proteolysis in the male reproductive system." @default.
• W1753314883 created "2016-06-24" @default.
• W1753314883 creator A5015634061 @default.
• W1753314883 creator A5041256841 @default.
• W1753314883 creator A5042935371 @default.
• W1753314883 creator A5043570965 @default.
• W1753314883 creator A5047505231 @default.
• W1753314883 creator A5054517338 @default.
• W1753314883 creator A5067452091 @default.
• W1753314883 creator A5068688177 @default.
• W1753314883 date "2004-07-08" @default.
• W1753314883 modified "2023-10-16" @default.
• W1753314883 title "Cystatin C Is Highly Expressed in the Human Male Reproductive System" @default.
• W1753314883 cites W1530238672 @default.
• W1753314883 cites W1671715542 @default.
• W1753314883 cites W1699719812 @default.
• W1753314883 cites W1704706435 @default.
• W1753314883 cites W1737088483 @default.
• W1753314883 cites W1805256772 @default.
• W1753314883 cites W1889298235 @default.
• W1753314883 cites W1964279511 @default.
• W1753314883 cites W1985841718 @default.
• W1753314883 cites W1988575537 @default.
• W1753314883 cites W2003663340 @default.
• W1753314883 cites W2008390180 @default.
• W1753314883 cites W2008827766 @default.
• W1753314883 cites W2029963258 @default.
• W1753314883 cites W2035875665 @default.
• W1753314883 cites W2040469503 @default.
• W1753314883 cites W2046063243 @default.
• W1753314883 cites W2048446809 @default.
• W1753314883 cites W2054425455 @default.
• W1753314883 cites W2056488199 @default.
• W1753314883 cites W2057775370 @default.
• W1753314883 cites W2059596763 @default.
• W1753314883 cites W2062530800 @default.
• W1753314883 cites W2064933937 @default.
• W1753314883 cites W2084786578 @default.
• W1753314883 cites W2095042767 @default.
• W1753314883 cites W2105834219 @default.
• W1753314883 cites W2126803505 @default.
• W1753314883 cites W2139258764 @default.
• W1753314883 cites W2152991626 @default.
• W1753314883 cites W2164768806 @default.
• W1753314883 cites W2258715357 @default.
• W1753314883 cites W2273833263 @default.
• W1753314883 cites W2770570613 @default.
• W1753314883 cites W4237183376 @default.
• W1753314883 cites W4240376307 @default.
• W1753314883 cites W4252162043 @default.
• W1753314883 cites W4293247451 @default.
• W1753314883 doi "https://doi.org/10.1002/j.1939-4640.2004.tb02827.x" @default.
• W1753314883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15223845" @default.
• W1753314883 hasPublicationYear "2004" @default.
• W1753314883 type Work @default.
• W1753314883 sameAs 1753314883 @default.
• W1753314883 citedByCount "31" @default.
• W1753314883 countsByYear W17533148832012 @default.
• W1753314883 countsByYear W17533148832013 @default.
• W1753314883 countsByYear W17533148832014 @default.
• W1753314883 countsByYear W17533148832015 @default.
• W1753314883 countsByYear W17533148832016 @default.
• W1753314883 countsByYear W17533148832017 @default.
• W1753314883 countsByYear W17533148832018 @default.
• W1753314883 countsByYear W17533148832019 @default.
• W1753314883 countsByYear W17533148832020 @default.
• W1753314883 countsByYear W17533148832022 @default.
• W1753314883 crossrefType "journal-article" @default.
• W1753314883 hasAuthorship W1753314883A5015634061 @default.
• W1753314883 hasAuthorship W1753314883A5041256841 @default.
• W1753314883 hasAuthorship W1753314883A5042935371 @default.
• W1753314883 hasAuthorship W1753314883A5043570965 @default.
• W1753314883 hasAuthorship W1753314883A5047505231 @default.
• W1753314883 hasAuthorship W1753314883A5054517338 @default.
• W1753314883 hasAuthorship W1753314883A5067452091 @default.
• W1753314883 hasAuthorship W1753314883A5068688177 @default.
• W1753314883 hasBestOaLocation W17533148831 @default.
• W1753314883 hasConcept C104317684 @default.
• W1753314883 hasConcept C105580179 @default.
• W1753314883 hasConcept C121608353 @default.
• W1753314883 hasConcept C126322002 @default.
• W1753314883 hasConcept C134018914 @default.
• W1753314883 hasConcept C153911025 @default.
• W1753314883 hasConcept C203014093 @default.
• W1753314883 hasConcept C204232928 @default.
• W1753314883 hasConcept C2776235491 @default.
• W1753314883 hasConcept C2778210472 @default.
• W1753314883 hasConcept C2779548226 @default.
• W1753314883 hasConcept C2780306776 @default.
• W1753314883 hasConcept C2780412452 @default.
• W1753314883 hasConcept C2781087480 @default.
• W1753314883 hasConcept C2781171107 @default.
• W1753314883 hasConcept C2781254305 @default.
• W1753314883 hasConcept C4224716 @default.
• W1753314883 hasConcept C54355233 @default.
• W1753314883 hasConcept C55493867 @default.
• W1753314883 hasConcept C59822182 @default.
• W1753314883 hasConcept C71924100 @default.

• next